On September 8, 2022 Hummingbird Bioscience, a data-driven precision biotherapeutics company discovering and developing transformative biologic medicines for hard-to-treat diseases, reported that Johann de Bono, Regius Professor of Cancer Research and a Professor in Experimental Cancer Medicine at The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, will present a trial in progress poster outlining the Phase 1 clinical trial design for HMBD-001 at the European Society for Medical Oncology Congress (ESMO 2022) (Press release, Hummingbird Bioscience, SEP 8, 2022, View Source [SID1234619250]). Hummingbird Bioscience management will attend ESMO (Free ESMO Whitepaper) 2022, which takes place in Paris from 9-13 September 2022.
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The Phase 1 clinical trial in the United Kingdom is being sponsored and managed by Cancer Research UK’s Centre for Drug Development and led by Chief Investigator, Professor Johann De Bono.
The trial began enrolling in October 2021 and is ongoing in the UK. The trial in progress poster will summarize the Phase 1 clinical trial design for HMBD-001 (NCT05057013). The Phase 1, open-label, multi-center, first-in-human trial seeks to evaluate HMBD-001 as a monotherapy and in combination with other agents to determine the maximum tolerated dose and investigate the anti-cancer activity of HMBD-001.
"We are excited to discuss our Phase 1 clinical strategy for HMBD-001 and longer-term clinical development plans with the wider oncology community at ESMO (Free ESMO Whitepaper) 2022," said Jerome Boyd-Kirkup, Ph.D., Chief Scientific Officer. "The unique mechanism of action of HMBD-001 gives us hope that HMBD-001 will provide significant benefit to patients with HER3-driven cancers."
Nigel Blackburn, Ph.D., Director of Cancer Research UK’s Centre for Drug Development, said: "Our Centre for Drug Development has an outstanding track record in designing and managing clinical trials, so we are really proud to see that this work, in collaboration with Hummingbird Bioscience, will be showcased to an audience of our peers at the ESMO (Free ESMO Whitepaper) 2022 conference."
ESMO Poster Presentation Details
Poster Title: A CRUK phase I/IIA, first in human dose-escalation and expansion trial of HMBD-001 (an anti-HER-3 antibody) in patients with advanced HER3-positive solid tumours
Number: 493 TiP
Date: Monday, 12th September, 2022
Poster Hours: 09:00-17:00 CEST (discussion: 12:00-13:00 CEST)
Location: Poster Area, Hall 4, Paris Expo Porte de Versailles, Paris, France
About HMBD-001
HMBD-001 is a clinical-stage IgG1 antibody designed to target HER3. Discovered using Hummingbird Bioscience’s proprietary Rational Antibody Discovery (RAD) platform, HMBD-001 is now in development for the treatment of multiple solid tumors. We believe HMBD-001 is the only anti-HER3 antibody in development that has the potential to fully block both ligand-dependent and -independent HER3 activation and oncogenic signaling, by targeting a key epitope located at the interface where HER3 forms heterodimers with HER2 or EGFR. In preclinical models evaluating HMBD-001, the company has observed superior affinity and more potent tumor growth inhibition compared to existing anti-HER3 antibodies. Near-term development plans for HMBD-001 focus on a few priority, high-value indications with strong scientific rationale and supporting preclinical data, which includes HER3-driven cancers and NRG1 fusion-driven cancers.