GRAIL and Intermountain Healthcare Expand Partnership to Offer Galleri® Multi-Cancer Early Detection Blood Test to Eligible Patients in Utah

On May 17, 2022 GRAIL, LLC, a healthcare company whose mission is to detect cancer early when it can be cured, and Intermountain Healthcare reported that Galleri, GRAIL’s groundbreaking multi-cancer early detection (MCED) blood test, will be offered as a complement to existing single cancer screenings to help advance the delivery of cancer care through early detection (Press release, Grail, MAY 17, 2022, View Source [SID1234614769]). Starting this month, Intermountain will offer the Galleri test to eligible health system patients at elevated risk for cancer, such as adults over 50 years old or with additional risk factors. In addition, the test will be available to eligible employees and their families who are enrolled in a company-sponsored health plan.

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"When it comes to cancer, we promote proactive measures through preventive screening wherever possible because it leads to better outcomes," said Dr. Naresh Agarwal, associate chief medical officer for primary care at Intermountain Healthcare. "The continuing partnership with GRAIL provides us with additional resources to detect cancer in its early, more treatable stages, directly aligning with our commitment to help people live the healthiest lives possible."

Early detection is known to improve cancer outcomes, yet, today, most cancer is detected too late because only five cancer types have recommended screenings – breast, cervical, colon, lung and prostate cancers. The Galleri test is the first-of-its-kind multi-cancer early detection blood test available. Using advanced genomics and machine learning, in a clinical study, the Galleri test was able to detect signals across more than 50 types of cancer, more than 45 of which lack recommended screening tests, with a low false positive rate of less than 1%. The test also can determine where in the body the cancer signal comes from with high accuracy.

Intermountain, the largest private employer in Utah, is a not-for-profit health system with 33 hospitals and more than 3,800 physicians. The system serves residents with hospitals and clinics in seven states and additional operations across the western United States.

"We are pleased to be expanding our partnership with Intermountain, a recognized leader in healthcare innovation, to expand its cancer screening capabilities with MCED," said Josh Ofman, MD, MSHS, president and chief medical officer at GRAIL. "Intermountain is a partner in the interventional PATHFINDER study evaluating the implementation and performance of the Galleri test in a clinical care setting and we’re grateful for their ongoing commitment to continuing to build the body of clinical evidence for the Galleri test. We applaud Intermountain’s forward-thinking approach to patient care so that, together, we can make progress against this devastating disease."

Initial results from PATHFINDER were presented at the 2021 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper), demonstrating that the performance of the Galleri test was consistent with findings from previous observational studies and underscoring the potential real-world ability of the Galleri test to find deadly cancers earlier. Final results from PATHFINDER will be presented at a medical meeting later this year.

About Intermountain Healthcare

Based in Utah with locations in seven states and additional operations across the western U.S., Intermountain Healthcare is a nonprofit system of 33 hospitals, 385 clinics, medical groups with some 3,800 employed physicians and advanced practice providers, a health plans division called SelectHealth with more than 1 million members, and other health services. Helping people live the healthiest lives possible, Intermountain is committed to improving community health and is widely recognized as a leader in transforming healthcare by using evidence-based best practices to consistently deliver high-quality outcomes at sustainable costs.

Epizyme To Participate in H.C. Wainwright Global Investment Conference

On May 17, 2022 Epizyme (Nasdaq: EPZM), a fully integrated, commercial-stage biopharmaceutical company developing and delivering transformative therapies for cancer patients against novel epigenetic targets, reported that Grant Bogle, President and Chief Executive Officer, and Shefali Agarwal, Senior Medical Advisor and Interim Chief Medical and Development Officer, will present at the H.C. Wainwright Global Investment Conference (Press release, Epizyme, MAY 17, 2022, View Source [SID1234614768]).

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A pre-recorded fireside chat will be available to play on demand stating at 7:00am EST on Tuesday, May 24, 2022. It can be found in the investor section of the Company’s website at www.epizyme.com and will be archived after 60 days following the presentation.

Aptorum Group Limited to Present at the H.C. Wainwright Global Investment Conference, May 23 – 26 2022

On May 17, 2022 Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) a clinical stage biopharmaceutical company dedicated to meeting unmet medical needs in oncology, autoimmune diseases and infectious diseases, reported that Mr. Darren Lui, President and Executive Director of Aptorum Group will present virtually at the H.C. Wainwright Global Investment Conference being held on May 23-26, 2022 (Press release, Aptorum, MAY 17, 2022, View Source [SID1234614767]).

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Aptorum Group management will be available and conducting online one-on-one meetings with institutional investors through the conference. To register for the conference, please visit: View Source

CytRx Highlights Strategic Purchase of Arimoclomol by KemPharm, Inc.

On May 17, 2022 CytRx Corporation (OTCQB: CYTR) ("CytRx" or the "Company"), a biopharmaceutical innovator focused on research and development of life-saving cancer therapeutics, reported to highlight the strategic purchase of arimoclomol by KemPharm, Inc. ("KemPharm") (Press release, CytRx, MAY 17, 2022, View Source [SID1234614766]).

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KemPharm is a specialty biopharmaceutical company focused on the discovery and development of novel treatments for rare central nervous system ("CNS") diseases. KemPharm has announced a definitive agreement with Orphazyme A/S ("Orphazyme") to acquire arimoclomol, a first-in-class heat shock protein potentiator being developed as a treatment for Niemann-Pick disease type C ("NPC"). NPC is a rare neurodegenerative disease characterized by abnormal accumulation of cholesterol and lipids in neuronal tissues. Under the terms of the agreement, KemPharm will purchase substantially all of the assets and operations of Orphazyme, including arimoclomol, for a cash payment of USD $12.8 million. The transaction is expected to close on or before June 1, 2022.

CytRx licensed arimoclomol to Orphazyme for milestones and royalties on sales, and CytRx expects the terms of its license with Orphazyme to remain intact as the arimoclomol asset transfers to KemPharm.

In the press release issued by KemPharm, Travis Mickle, Ph.D., President and Chief Executive Officer of KemPharm stated, "The acquisition of arimoclomol aligns perfectly with our strategy to build KemPharm’s value via the advancement and commercialization of novel treatments that address rare CNS conditions, including our lead clinical candidate, KP1077 in idiopathic hypersomnia. We have carefully evaluated the CRL issued by the FDA and the minutes from the subsequent Type A meeting, as well as the data that has been generated from the development work performed to date. We believe the efficacy signal for arimoclomol in NPC is convincing and that there is a viable regulatory path that could enable a successful NDA resubmission. KemPharm has significant experience with challenging regulatory situations, having successfully led or participated in three FDA product approvals, two of which followed an initial CRL. We welcome the opportunity to work with the FDA on the resubmission of the NDA for arimoclomol in NPC, which we expect to file as early as the first quarter of 2023."

Stephen Snowdy, PhD, Chief Executive Officer of CytRx commented, "CytRx is very pleased to see that arimoclomol will enjoy the support and resources of KemPharm, and that KemPharm sees value in the human trials data collected on arimoclomol through the course of 10 Phase 1, four Phase 2 and three pivotal Phase 2/3 trials. We are especially pleased to see that KemPharm, with its experience in challenging regulatory submissions, plans to re-submit arimoclomol to the FDA as early as Q1 2023. With a mean age of death of 13 years, patients desperately need a solution to Niemann-Pick disease type C."

MEI Pharma to Present at the H.C. Wainwright Global Investment Conference 2022

On May 17, 2022 MEI Pharma, Inc. (NASDAQ: MEIP), a late-stage pharmaceutical company focused on advancing new therapies for cancer, reported its participation in the H.C. Wainwright Global Investment Conference 2022 (Press release, MEI Pharma, MAY 17, 2022, View Source [SID1234614765]). The company will present a company overview and business update available for on-demand listening starting Tuesday, May 24, 2022, 7:00 a.m. Eastern Time that will be archived for 90 days.

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The presentation can be accessed via the Events & Presentations page of the Investors section of MEI Pharma’s website at View Source An archived replay of the webcast will be available on MEI Pharma’s website for at least 30 days after the live event concludes.