On April 28, 2022 Illumina, Inc. (NASDAQ: ILMN) reported that its executives will be speaking at the following investor conference (Press release, Illumina, APR 28, 2022, View Source [SID1234613186]):

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BofA Securities 2022 Healthcare Conference on May 12, 2022
Fireside Chat at 12:00pm Pacific Time (3:00pm Eastern Time)
The live webcast can be accessed under the Investor Info section of Illumina’s website under the "company" tab at www.illumina.com. A replay will be posted on Illumina’s website after the event and will be available for at least 30 days following.

On April 28, 2022 Vanda Pharmaceuticals Inc. (Vanda) (Nasdaq: VNDA) reported it will release results for the first quarter 2022 on Thursday, May 5, 2022, after the market closes (Press release, Vanda Pharmaceuticals, APR 28, 2022, View Source [SID1234613185]).

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Vanda will host a conference call at 4:30 PM ET on Thursday, May 5, 2022, during which management will discuss the first quarter 2022 financial results and other corporate activities. To participate in the conference call, please dial 1-866-688-9426 (domestic) or 1-409-216-0816 (international) and use passcode 1355275.

The conference call will be broadcast simultaneously and archived on Vanda’s website, www.vandapharma.com. Investors should go to the website at least 15 minutes early to register, download, and install any necessary audio software.

A replay of the call will be available on Thursday, May 5, 2022, beginning at 7:30 PM ET and will be accessible until Thursday, May 12, 2022, at 7:30 PM ET. The replay call-in number is 1-855-859-2056 for domestic callers and 1-404-537-3406 for international callers. The passcode number is 1355275.

On April 28, 2022 Transcenta Holding Limited ("Transcenta") (HKEX: 06628), a clinical stage biopharmaceutical company with fully-integrated capabilities in discovery, research, development and manufacturing of antibody-based therapeutics, reported that the abstracts of TST001 and MSB0254 have been accepted by the 2022 annual meeting of American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) ("2022 ASCO (Free ASCO Whitepaper) Annual Meeting") (Press release, Transcenta, APR 28, 2022, View Source [SID1234613184]). The abstracts are named "A Phase I Study of TST001, a High Affinity Humanized Anti-CLDN18.2 Monoclonal Antibody, in Combination with Capecitabine and Oxaliplatin (CAPOX) as a First Line Treatment of Advanced G/GEJ Cancer" and "A Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MSB0254 in Chinese Solid Tumor Patients" respectively.

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The ASCO (Free ASCO Whitepaper) Annual Meeting showcases the most cutting-edge research in clinical oncology and state-of-the-art advanced cancer therapies and is the world’s most influential and prominent scientific gathering of the clinical oncology community. This year’s ASCO (Free ASCO Whitepaper) Annual Meeting will take place both online and in-person (McCormick Place; Chicago, IL) on June 3–7, 2022.

TST001 (Claudin18.2)
Abstract Number: 4062
Session Date and Time: June 4, 2022, 8:00 AM-11:00 AM CDT
Title: A Phase I Study of TST001, a High Affinity Humanized Anti-CLDN18.2 Monoclonal Antibody, in Combination with Capecitabine and Oxaliplatin (CAPOX) as a First Line Treatment of Advanced G/GEJ Cancer
First author: Professor Jifang Gong, Peking University Cancer Hospital and Research Institute
Presentation Format: Poster

MSB0254 (VEGFR2)
Abstract Number: 3023
Session Date and Time: June 5, 2022, 8:00 AM-11:00 AM CDT
Title: A Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MSB0254 in Chinese Solid Tumor Patients
First author: Professor Tianshu Liu, Zhongshan Hospital, Fudan University
Presentation Format: Poster

About TST001

TST001 is a high affinity humanized anti-Claudin18.2 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities and potent anti-tumor activities in tumor xenograft models. TST001 is the second Claudin18.2 targeting antibody therapeutic candidate being developed globally. TST001 is generated using Transcenta’s Immune Tolerance Breaking Technology (IMTB) platform. TST001 kills Claudin18.2 expressing tumor cells by mechanisms of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Leveraging advanced bioprocessing technology, the fucose content of TST001 was significantly reduced during the production, which further enhanced NK cells mediated ADCC activity of TST001. Clinical trials for TST001 are ongoing in China and US (NCT04396821, NCT04495296/CTR20201281). TST001 was granted Orphan Drug Designation in the US by FDA for the treatment of patients with gastric cancer or gastroesophageal junction (GC/GEJ).

About MSB0254

MSB0254 is a high affinity humanized anti-VEGFR-2 mAb, with an anti-tumor mechanism of action by inhibiting tumor angiogenesis. MSB0254 has been generated using Transcenta’s in-house antibody discovery platform. VEGFR-2 is overexpressed in neovascular tumor endothelial cells in many tumors in comparison to normal endothelial cells. Vascular permeability, survival and migration of the vascular endothelial cells are controlled by the VEGFR-2 pathway. VEGFR-2 inhibitors has been shown to be able to inhibit tumor-induced angiogenesis and effectively block tumor growth, and thus may have a potential therapeutic role in multiple tumor types.

On April 28, 2022 Veracyte, Inc. (Nasdaq: VCYT) reported that three abstracts highlighting new data on the genomic underpinnings of prostate and bladder cancers will be presented at the American Urological Association Annual Meeting, taking place May 13-16, 2022, in New Orleans (Press release, Veracyte, APR 28, 2022, View Source [SID1234613183]). The findings are derived from analyses of the Decipher GRID, a database that contains genomic profiling information from clinical samples used in the development and commercial application of the Decipher Prostate and Decipher Bladder tests.

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"The data being presented at AUA 2022 highlight the transcriptional complexity of prostate and bladder cancers, knowledge that we hope can be used to better personalize therapy," said Elai Davicioni, Ph.D., Veracyte’s medical director for Urology. "Importantly, these analyses also reinforce the value of our Decipher GRID database, which contains over 100,000 transcriptomes of prostate and bladder cancers, for urologic oncology researchers all around the world."

On April 28, 2022 DermTech, Inc. (NASDAQ: DMTK) ("DermTech" or the "Company"), a leader in precision dermatology enabled by a non-invasive skin genomics platform, reported the publication of "Noninvasive Genomic Characterization of Patients with Nonsclerotic and Superficially Sclerotic Chronic Cutaneous Graft-Versus-Host Disease Identified a Novel Gene Signature in Responders to Ruxolitinib Cream," in Transplantation and Cellular Therapy (Press release, DermTech International, APR 28, 2022, View Source [SID1234613182]).

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Graft versus host disease (GvHD) occurs when transplanted donor immune cells attack the recipient’s healthy cells and tissues. Dermatologic manifestations are an important aspect of GvHD, as they are often the earliest organ affected in GvHD and develop in more than half of GvHD patients. While oral ruxolitinib, a JAK1/2 inhibitor, has been approved by the U.S. Food & Drug Administration (FDA) for the treatment of acute and chronic GvHD (cGvHD), this is the first clinical trial evaluating the effectiveness of topical ruxolitinib in cutaneous GvHD patients.

Skin samples were non-invasively collected from cutaneous GvHD patients using the DermTech Smart StickerTM and subsequently analyzed by RNA sequencing to investigate the effect of topical ruxolitinib on gene expression in cGvHD. Specifically, the study evaluated the genomic differences between treatment with ruxolitinib cream and vehicle cream and the distinction between patients who responded to treatment and those who did not.

"Noninvasive characterization and prognostication of therapeutic response are needed for GvHD therapies," said Dr. Alina Markova, lead author and Assistant Attending of Dermatology at Memorial Sloan Kettering Cancer Center. "This is the first study to characterize the effect of topical JAK1/2 blockade with ruxolitinib cream on cutaneous cGVHD and differentiate the genomic signatures between responders and non-responders."

Bioinformatic analyses of Smart StickerTM collected skin samples successfully identified 210 differentially expressed genes (DEGs) between topical ruxolitinib and vehicle treatments with primary pathway differences in immune modulation and cell-signaling. Additionally, 383 DEGs were identified which differentiated patients who responded to treatment from those who did not.

"We are proud to partner with the Memorial Sloan Kettering Cancer Center to advance research on treatment for cutaneous GvHD patients and provide clinicians with objective genomic information to help identify patients that may benefit from treatment," said Michael Howell, PhD, chief scientific officer of DermTech. "This collaboration further demonstrates DermTech Stratum’s capabilities in offering translational medicine services to bring heightened precision and personalization to the diagnosis and treatment of dermatologic disease."

For additional information about DermTech Stratum, visit View Source