On May 6, 2022 Bausch Health Companies Inc. (NYSE/TSX: BHC) (Bausch Health) reported its full leadership team and Board of Directors, including Chief Executive Officer (CEO) Thomas J. Appio.1 Upon completion of the initial public offering (IPO) of the Bausch + Lomb eye health business,2 former CEO Joseph C (Press release, Bausch Health, MAY 6, 2022, View Source [SID1234613805]). Papa will assume the role of chairman and CEO of Bausch + Lomb.

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"It is an honor and privilege to lead Bausch Health at this pivotal time in its history, and I am excited for our future," said Mr. Appio. "We are a global specialty pharmaceutical company with deep expertise in gastroenterology, hepatology, neurology, dermatology and international pharmaceuticals serving patients for more than 60 years."

"As we begin operating as a separate organization, we will leverage our commercial capabilities to grow access to our therapies and expand our market reach, and we will invest in innovation and new business development to build a future product pipeline to address unmet needs. I look forward to leading our talented team of 7,000 global employees toward the exciting opportunities ahead," continued Mr. Appio.

Strong, Experienced Leaders Selected for Executive Management Team1
The Bausch Health executive management team, which is comprised of experienced leaders with years of expertise in their respective areas, includes:

Thomas J. Appio, Chief Executive Officer
Thomas (Tom) Vadaketh, Executive Vice President, Chief Financial Officer
Seana Carson, Executive Vice President, General Counsel
Mirza Dautbegovic, Senior Vice President, Chief Operating Officer
Kathleen Fitzpatrick, Senior Vice President, Chief Human Resources Officer
Jeff Hartness, Senior Vice President, Market Access, Commercial Operations & Government Affairs
Cees Heiman, Senior Vice President, Europe and Canada
Graham Jackson, Senior Vice President, Chief Quality Officer
Tage Ramakrishna, M.D., Chief Medical Officer and President of R&D
Robert Spurr, President of the U.S. business
Fernando Zarate, Vice President, Latin America
Bausch Health to Appoint Dr. Richard Mulligan to the Board of Directors1
In addition to the appointment of Mr. Appio as CEO and a member of the Board of Directors, Richard Mulligan, Ph.D., will be appointed to the Bausch Health Board of Directors.

Dr. Mulligan is currently the Mallinckrodt Professor of Genetics, Emeritus, at Harvard Medical School, after serving as the Mallinckrodt Professor of Genetics and director of the Harvard Gene Therapy Initiative from 1996 to 2013. He also serves as executive vice chairman of the Board of Sana Biotechnology, Inc. From March 2017 to October 2018, he served as a portfolio manager at Icahn Capital LP. Prior to that, he was a professor of Molecular Biology at the Massachusetts Institute of Technology, a member of the Whitehead Institute for Biomedical Research and chief scientific officer of Somatix Therapy Corporation, a drug discovery and development company that he founded. Dr. Mulligan was a founding partner of Sarissa Capital Management LP from 2013 to 2016. He was named a MacArthur Foundation Fellow in 1981.

Mr. Papa will remain in the role of chairman of the Board of Directors for Bausch Health until the full separation of Bausch + Lomb, at which time Robert N. Power will succeed as chairman.

Upon completion of the IPO, the Bausch Health Board of Directors will include the following individuals:

Joseph C. Papa, Chairman
Robert N. Power
Thomas J. Appio
Richard U. DeSchutter
Brett Icahn
Argeris (Jerry) N. Karabelas, Ph.D.
Sarah B. Kavanagh
Steven D. Miller
Richard Mulligan, Ph.D.
Russel C. Robertson
Thomas W. Ross, Sr.
Amy B. Wechsler, M.D.
For more information about the company’s leadership and Board of Directors, please visit www.bauschhealth.com.

Bausch Health will continue to be headquartered in Laval, Quebec, and will continue to trade on the New York Stock Exchange and Toronto Stock Exchange under its present symbol, "BHC".

On May 6, 2022 Cytovia Therapeutics, LLC ("Cytovia Therapeutics"), a global biotechnology company focused on harnessing the power of natural killer (NK) cells to fight cancer through multispecific antibodies and stem cell engineering, reported that it will be presenting at the AACR (Free AACR Whitepaper) Special Conference on Advances in the Pathogenesis and Molecular Therapies of Liver Cancer, to be held from May 5-8, 2022, at the Westin Copley Place in Boston, Massachusetts (Press release, Cytovia Therapeutics, MAY 6, 2022, View Source [SID1234613804]). The conference is an in-person event and will not live-stream content, but Cytovia Therapeutics’s short poster video will be available for on-demand viewing by conference registrants after the conference and Cytovia Therapeutics’s poster will be available on its website under the "Resources" section.

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Details of Cytovia’s poster presentation:
Abstract title: Preclinical activity of glypican-3 (GPC3) and NKp46 directed FLEX-NK engager antibody (CYT-303) in combination with iPSC derived natural killer cells (iNKs) or peripheral blood (PB) NK cells in hepatocellular carcinoma (HCC)

Session: Poster Session/Reception
Session Date and Start Time: Friday, May 6, 5:30-7:30 p.m.

Conclusions from the poster:

The FLEX-NKTM multifunctional engager antibody CYT-303 directed against NKp46 and GPC3 demonstrated potent single agent anti-tumor activity:
potent NK cell cytotoxicity against HCC tumor cells accompanied by cytokine production in an in vitro model indicative of NK cell engagement and activation
HCC tumor growth inhibition in an in vivo model
Favorable cytokine release and immune cell subset safety profile
iNK cells expressed a favorable combination of multiple activation and few inhibitory receptors that facilitated potent cytolytic activity against HCC tumors
The combination of the FLEX-NKTM and iNK cells demonstrated greater in vitro and in vivo anti-tumor activity in HCC tumor models than iNK cells alone
The preclinical proof of concept studies with CYT-303 alone or in combination with iNK cells in HCC warrant clinical development

On May 6, 2022 Tempus, a leader in artificial intelligence and precision medicine, reported a multi-year agreement with the United States Department of Veterans Affairs (VA) National Precision Oncology Program (NPOP) designed to expand access to Tempus’ portfolio of next-generation sequencing offerings to support physicians in delivering personalized treatment approaches for their patients with cancer (Press release, Tempus, MAY 6, 2022, View Source [SID1234613803]). The Veterans Health Administration is the largest integrated health system in the U.S., providing care to more than nine million Veterans annually.

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The NPOP is leveraging Tempus’ broad range of comprehensive molecular profiling capabilities in an effort to improve patient outcomes with precision medicine. As part of the collaboration, providers across the VA’s 171 Medical Centers can leverage Tempus’ next-generation sequencing tests, including its solid tumor/normal assay and liquid biopsy assay. In the event of insufficient tumor tissue, Tempus offers a conversion option to a blood-based liquid biopsy test which seamlessly delivers genomic results without a delay to the clinician or the patient.

"Our AI-enabled tests combine high-quality and comprehensive genomic data with clinical data for each patient being sequenced, which allows physicians to make truly personalized decisions as they seek the optimal therapy for their patients," said Eric Lefkofsky, Founder and CEO of Tempus. "We look forward to supporting the VA as they expand access to precision medicine solutions in oncology care to those who have served our country and deserve the very best care we have to offer."

On May 6, 2022 InterVenn Biosciences, the leader in applied glycoproteomics, reported that it will present new clinical data detailing the success of its novel approach to liquid biopsy testing in multiple cancer indications at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2022 Annual Meeting (Press release, InterVenn Biosciences, MAY 6, 2022, View Source [SID1234613802]). The meeting will take place from June 3 to June 7 at McCormick Place in Chicago.

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InterVenn will present two posters and five online publications highlighting data that demonstrate clinically relevant applications of its glycoproteomics-based biomarker signatures in a variety of cancers, including malignant melanoma, ovarian cancer, colorectal cancer, non-small-cell lung carcinoma, and bone and soft tissue sarcoma.

"We look forward to sharing our data at ASCO (Free ASCO Whitepaper) 2022 further validating the power of InterVenn’s pioneering glycoproteomic biomarker signatures to transform clinical care in cancer," said InterVenn CEO Aldo Carrascoso. "As a mission-driven company, InterVenn is building a robust pipeline of accessible, clinically validated and powerful tests, with the aim of detecting cancer earlier, treating it more effectively, and saving lives."

The InterVenn approach addresses many of the common challenges associated with liquid biopsy analysis by industrializing the process of glycoproteomics-based blood testing at high accuracy with fast turnaround times. Unlike other non-invasive methods, it does not depend on detecting material shed by tumors, and therefore allows the detection of very early-stage, potentially curable tumors that are commonly missed by other technologies. It also requires a significantly lower blood sample volume than most other analytical platforms.

InterVenn Presentations at ASCO (Free ASCO Whitepaper) 2022

Poster Presentations:

Title: "Serum glycoproteomic signatures predict overall survival in bone and soft tissue sarcoma patients treated with immune checkpoint inhibitor therapy"
Presenter: D. Serie, C. Pickering, R. Rice, M. Wong, H. Huang, M. Kansara, DM. Thomas, and K. Lindpaintner

Title: "Glycoproteomics as a powerful liquid biopsy-based predictor of checkpoint-inhibitor treatment benefit in metastatic malignant melanoma"
Presenter: A. Mitchell, C. Pickering, G. Xu, K. Vigal, B. Axenfeld, R. Rice, X. Cong, D. Frederick, W. A. Michaud, G. Boland, D. Serie, and K. Lindpaintner

Online Publications:

Title: "Glycoproteomics as a powerful liquid biopsy based screening tool for NSCLC"
Author: C. Pickering, G. Xu, R. Rice, A. Castellanos, R. Bhadra, L. Brcic, J. Lindenmann, F.M. Smolle-Juettner, K. Lindpaintner, D. Serie, and A. Mitchell

Title: "Clinicians’ perspectives on use of immune checkpoint inhibitors and related biomarkers for solid tumors"
Author: K. Moser, M. Soto, D. Geba, P. Allen, and K. Lindpaintner

Title: "Identifying potential glycoproteomic biomarkers for diagnosis of colorectal cancer"
Author: K. Desai, G. Xu, R. Rice, A. Castellanos, D. Serie, A. Mitchell, and K. Lindpaintner

Title: "Liquid-biopsy derived glycoproteomic profiling as a novel means for non-invasive diagnosis of ovarian cancer"
Author: C. Pickering, P. Aiyetan, G. Xu, R. Rice, P. Ramachandran, K. Moser, D. Serie, and K. Lindpaintner

Title: "Predicting Breast Cancer in Women using Liquid Biopsy-Derived Glycoproteomic Marker"
Author: A. Mitchell, A. Srinivasan, G. Xu, R. Rice, A. Castellanos, R. Bhadra, D. Serie, X. Cong, and K. Lindpaintner

On May 6, 2022 Ambrx Biopharma Inc., or Ambrx, (NYSE: AMAM), a clinical stage biopharmaceutical company using an expanded genetic code technology platform to create Engineered Precision Biologics (EPBs), reported that Feng Tian, Ph.D., Chairman of the Board, President and CEO of Ambrx, will present at two upcoming investor conferences in May (Press release, Ambrx, MAY 6, 2022, View Source [SID1234613801]).

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Bank of America 2022 Healthcare Conference. Dr. Tian will participate in an analyst led fireside chat on Wednesday, May 11 at 12:00 PM Pacific Time / 3:00 PM Eastern Time.

H.C. Wainwright Global Investment Conference. Dr. Tian will conduct a pre-recorded presentation that will be available on-demand on Tuesday, May 24 at 4:00 AM Pacific Time / 7:00 AM Eastern Time.

Interested parties can access the live and pre-recorded webcasts for these conferences from the Investor Relations section of the company’s website at www.Ambrx.com. The webcast replays will be available after the conclusion of the respective presentations for approximately 90 days.