On October 21, 2022 Elpiscience Biopharmaceuticals, Inc. ("Elpiscience"), a clinical-stage biopharmaceutical company focused on developing next-generation immunotherapies to benefit cancer patients worldwide, reported it will have five poster presentations at the SITC (Free SITC Whitepaper) 2022 Annual Meeting being held in Boston, Massachusetts from November 8-12 (Press release, Elpiscience, OCT 21, 2022, View Source [SID1234622273]). The posters will highlight studies on five innovative molecules including anti-SIRPα monoclonal antibody ES004, anti-LAG3 monoclonal antibody ES005, anti-LILRB2 monoclonal antibody ES009, anti-SIGLEC15 antibody ES012, and PD-L1/SIRPα bispecific macrophage engager ES019.

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Poster presentations:

1.Title: Treatment of anti-SIRPα in combination with anti-TAA exerts superior anti-tumor activity
Abstract No.: 793
Date and time: 11/10/2022, 9:00 am – 9:00 pm (EST)

2.Title: Dual targeting of innate and adaptive immune checkpoints with a PD-L1/SIRPα bispecific macrophage engager to promote anti-tumor activity
Abstract No.: 1211
Date and time: 11/10/2022, 9:00 am – 9:00 pm (EST)

3.Title: SIGLEC15 induces monocyte apoptosis and an SIGLEC15 antibody ES012 reverses myeloid cells driven immunosuppression
Abstract No.: 1401
Date and time: 11/10/2022, 9:00 am – 9:00 pm (EST)

4.Title: ES005, a high affinity anti-LAG3 monoclonal antibody, inhibits the interactions between LAG3 and multiple ligands and enhances anti-tumor activity of T cells in preclinical models
Abstract No.: 426
Date and time: 11/11/2022, 9:00 am – 9:00 pm (EST)

5.Title: ES009, a LILRB2-specific blocking antibody, reprograms myeloid cells into pro-inflammation phenotype and potentiates T cell activation
Abstract No.: 1062
Date and time: 11/11/2022, 9:00 am – 9:00 pm (EST)

On October 21, 2022 Mevion Medical Systems, the leading provider of compact proton therapy systems for use in radiation treatment for cancer patients, reported that introduced its new product, the MEVION S250-FIT Proton Therapy System (Press release, Mevion Medical Systems, OCT 21, 2022, View Source [SID1234622272]).

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Enabled by the world’s smallest self-shielded proton accelerator from Mevion, the MEVION S250-FIT will be the first and only full proton therapy system that can fit in an existing LINAC vault. The system will feature industry-leading HYPERSCAN Pencil Beam Scanning for Intensity Modulated Proton Therapy (IMPT), dual-energy large bore diagnostic CT at treatment position for IGRT and adaptive therapy, and FLASH research capabilities. It is also designed to support fast access to emerging technologies like ARC therapy.

Thanks to the compact size, the FIT system will further reduce the cost and complexity of proton therapy. As the name suggests, FIT will enable a Fast deployment of an Integrated design and bring the Transforming power of proton therapy to more cancer centers.

"The MEVION S250-FIT is a true quantum leap for proton accessibility. Fitting high-quality proton therapy inside a LINAC vault has always been a major goal in bringing the cost of proton closer to conventional X-ray, and as such, providing more access to this important therapy," said Jay Loeffler, MD, Chair Emeritus of Mass General Hospital and Co-Chair of Mevion’s Clinical and Technical Advisory Board.

"I have seen the clinical benefits of proton therapy for the past 20 years, especially for pediatric patients, and the idea that proton therapy could be accessible to all pediatric patients has always been my dream. I am so excited to hear of this innovation. This product could be a game changer," said Nancy Tarbell, MD, a world-renowned pediatric radiation oncologist, and CC Wang Professor emerita at Harvard Medical School and Mass General Hospital.

The FIT system will be developed in partnership with Leo Cancer Care, a medical device company based in Middleton, Wisconsin, with offices in Europe and North America. Leo Cancer Care is focused on bringing a "more human" approach to delivering radiation therapy and utilizes upright positioning to improve patient experience, clinical effectiveness, and access to radiotherapy.

"Mevion Medical Systems has a proven 18-year track record of technological innovation. We are excited to be disrupting the industry once again by shrinking proton therapy even more and by making this coveted technology much more accessible to patients who need it the most. Imagine the potential of bringing proton therapy to your cancer center within a year and having it fully integrated with other radiation modalities," said Tina Yu, PhD, CEO and President of Mevion Medical Systems. "Leo Cancer Care’s upright patient positioning system complements Mevion’s core technologies very well. They share our vision of democratizing proton therapy. We look forward to a long and rewarding partnership with Leo Cancer Care."

"Leo Cancer Care, like Mevion, has been focusing on the patient experience. Together, Leo and Mevion agreed we wanted to take proton therapy where we never thought it could go, and together we will be achieving what was once thought impossible. In working with Mevion, we will be able to scale down proton therapy in size and cost so that it can be within reach of patients who will benefit from it most," said proton therapy champion and veteran entrepreneur Rock Mackie, PhD, Board Chairman and Co-Founder of Leo Cancer Care.

Mevion will officially debut the MEVION S250-FIT Proton Therapy System at ASTRO’s 64th Annual Meeting in San Antonio, TX. Attendees are invited to join the unveiling at Mevion’s booth 566 at 2 PM CDT on October 23 and learn more about the system throughout the exhibition from October 23 – 25.

*The MEVION S250-FIT Proton Therapy System, FLASH therapy, online adaptive therapy, and ARC therapy are not yet available for clinical use.

On October 21, 2022 NeuBase Therapeutics, Inc. (Nasdaq: NBSE) ("NeuBase" or the "Company"), a biotechnology platform company Drugging the Genome to address disease at the base level using a new class of precision genetic medicines, reported a research agreement with a Top 10 Global Healthcare company ("Healthcare Company") (based on 2021 revenues) (Press release, NeuBase Therapeutics, OCT 21, 2022, View Source [SID1234622271]). For this research, the Healthcare Company will evaluate NeuBase’s PATrOL technology for three monogenic genetic diseases.

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NeuBase’s PATrOL platform is a PNA-based technology designed to address disease at the root of causality to help patients with rare and common diseases by editing, upregulating, or downregulating gene function. PATrOL gene editing is differentiated in that it does not require bacterial enzymes (e.g., CRISPR-Cas9), which potentially increases fidelity and reduces immunogenicity to provide a safer solution to patients for in vivo gene editing.

"Our PATrOL technology enables us to create a series of peptide nucleic acids (PNAs) designed to target a genetic mutation and recruit the cell’s own high fidelity nucleic acid repair machinery to resolve the mutation," stated Dietrich A. Stephan, Ph.D., Chief Executive Officer of NeuBase. "We look forward to working with our Healthcare Company partner to explore our novel gene editing technology for several genetic diseases."

Under the terms of the agreement, NeuBase and the Healthcare Company will collaborate on the evaluation of drug candidates for three undisclosed indications. The Healthcare Company will have the exclusive opportunity, subject to certain terms and conditions, to license and develop the drug candidates created under this research evaluation agreement.

On October 21, 2022 Autolus Therapeutics plc (Nasdaq: AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, reported that it will release its third quarter 2022 financial results and operational highlights before open of U.S. markets on Thursday, November 3, 2022 (Press release, Autolus, OCT 21, 2022, View Source [SID1234622270]).

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Management will host a conference call and webcast at 8:30 am ET/1:30 pm BST to discuss the company’s financial results and provide a general business update. Conference call participants should pre-register using this link to receive the dial-in numbers and a personal PIN, which are required to access the conference call.

A simultaneous audio webcast and replay will be accessible on the events section of Autolus’ website.

On October 21, 2022 Lantern Pharma Inc. (NASDAQ: LTRN), a clinical stage biopharmaceutical company using its proprietary RADR artificial intelligence ("A.I.") and machine learning ("M.L.") platform to transform the cost, pace, and timeline of oncology drug discovery and development, reported that Lantern management will be presenting at the ThinkEquity Conference, which is being held on October 26th, 2022 in New York, NY (Press release, Lantern Pharma, OCT 21, 2022, View Source [SID1234622269]).

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Panna Sharma, Lantern’s CEO & President, will be hosting an A.I. and Drug Development Panel at 10:00 a.m. ET focused on how A.I. is transforming the cost, pace, and risks involved in developing a new drug.

Panelists will include noted experts from Weill Cornell, Volastra Therapeutics, InveniAI, and Hepion Pharmaceuticals.
Lantern Pharma is scheduled to present at the conference on Wednesday, October 26th at 1:00 p.m. ET.
Webcast Link: View Source
Registration Link: View Source
Lantern Pharma management will be available for one-on-one meetings to be held throughout the conference.