On September 23, 2022 Lantern Pharma Inc. (NASDAQ: LTRN), a clinical stage biopharmaceutical company using its proprietary RADR artificial intelligence ("A.I.") and machine learning ("M.L.") platform to transform the cost, pace, and timeline of oncology drug discovery and development, reported that it will present preclinical data on the potency of Lantern’s drug candidate LP-284 for mantle cell lymphoma (MCL) and several other non-Hodgkin’s lymphomas at the Society of Hematologic Oncology (SOHO) Tenth Annual Meeting, Sept. 28 – Oct. 1, 2022, in Houston, TX (Press release, Lantern Pharma, SEP 23, 2022, View Source [SID1234621393]).

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LP-284 is a next generation acylfulvene that has a synthetically lethal mechanism of action in cancers with impaired DNA damage repair (DDR) pathway genes. In Lantern’s preclinical testing, LP-284 has shown in vitro and in vivo anti-tumor potency across a range of non-Hodgkin’s B-cell lymphomas. Of the lymphomas tested to date, LP-284 had the greatest potency against numerous MCL cell lines, including those that are resistant to the standard-of-care (SOC) agents Ibrutinib and Bortezomib. In the US, MCL is estimated to be diagnosed in around 4,500 patients each year and represents an approximate $200 million in annual therapy sales.

Lantern’s LP-284 program has been accelerated and de-risked using A.I. insights and biological modeling powered by RADR. Lantern has been able to advance LP-284 from initial RADR insights regarding anti-cancer activity and potential mechanisms of action in hematological cancers, to selection of specific subtypes of lymphomas with superior response, to late stage IND enabling studies and initial design of first in human clinical trials in less than 2 years. Lantern is planning on an IND submission for LP-284 in Q1 2023 and anticipates launching a Phase 1 clinical trial in Q2 2023.

Details of the poster presentation are listed below and can be found on the SOHO website. A full version of the poster will be available on Lantern’s website on October 3, 2022.

On September 23, 2022 EDAP TMS S.A. (NASDAQ: EDAP) (the "Company"), a global leader in robotic energy-based therapies, reported that it has commenced a public offering of its American Depositary Shares, or ADSs, each representing one ordinary share of the Company (Press release, EDAP TMS, SEP 23, 2022, View Source [SID1234621390]). The proposed offering is subject to market conditions, and there can be no assurance as to whether or when the proposed offering may be completed or as to the actual size or terms of the proposed offering.

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Jefferies LLC is acting as the sole book-running manager for the offering.

A shelf registration statement on Form F-3 (including a prospectus) relating to the Company’s American Depositary Shares was filed with the Securities and Exchange Commission (the "SEC") on April 7, 2021 and is effective. The Company has also filed a base prospectus dated April 16, 2021 and a preliminary prospectus supplement dated September 22, 2022 with respect to the proposed offering. Before purchasing ADSs in the offering, you should read the preliminary prospectus supplement and the accompanying prospectus, together with the documents incorporated by reference therein. You may obtain these documents for free by visiting EDGAR on the SEC’s website at www.sec.gov. Alternatively, a copy of the preliminary prospectus supplement (and accompanying prospectus) relating to the offering may be obtained from Jefferies LLC, Attn: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, New York 10022, by telephone at +1 (877) 821-7388 or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. In particular, no public offering of the ADSs will be made in Europe.

On September 23, 2022 Yumanity Therapeutics, Inc Presented the Corporate Presentation (Presentation, Yumanity Therapeutics, SEP 23, 2022, View Source [SID1234621389]).

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On September 23, 2022 Tiziana Life Sciences Ltd. (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company enabling breakthrough immunotherapies via novel routes of drug delivery, reported that it has been notified that Matthew Davis, its Chief Medical Officer, purchased 75,000 common shares at $0.83 per share, bringing his total holding to 175,000 common shares (Press release, Tiziana Life Sciences, SEP 23, 2022, View Source [SID1234621388]).

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On September 23, 2022 TechnoPhage reported the spin-off of T-Oncology AG, which will focus on the development of Antibody Drug Conjugates (ADCs), based on the proprietary Small Domain Antibodies platform (TechnoBodies), for the treatment of cancer (Press release, TechnoPhage, SEP 23, 2022, View Source;utm_medium=rss&utm_campaign=technophage-s-a-announces-spin-off-of-t-oncology-ag [SID1234621387]).

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TechnoBodies technology has been developed at TechnoPhage and, taking advantage of the small size of the fragment antibodies obtained, T-Oncology will construct and scale ADCs for targeted novel cancer therapy. Overall, this technology enables the sensitive discrimination between healthy and cancerous tissues and will be ultimately applied in unmet medical needs in the field of oncology.

It is also now clear to TechnoPhage’s management team that pursuing a spin-off is the most compelling path forward; indeed, "creating a new company specialized in a single technology and a specialized clinical indication can create significant value for our patients, partners and clients" said Miguel Garcia, CEO of TechnoPhage.

The new company incorporated in Kanton Zug, Switzerland, is expected to also set base as a resident in the Johnson & Johnson Life Science Incubators and Accelerators, at JLABS in Beerse, Belgium and start recruiting a new team in the next year.