Partial Revision of the Basic Alliance Agreement with Roche

On July 21, 2022 Chugai Pharmaceutical Co., Ltd. (hereafter "Chugai") reported that it resolved at the Board of Directors Meeting held today to partially revise the basic agreement for the strategic alliance (hereafter "Basic Alliance Agreement") between Chugai [Head Office: Tokyo, Japan. CEO: Osamu Okuda] and Roche Holding Ltd (hereafter "Roche") [Head Office: Basel, Switzerland. CEO: Severin Schwan], and that it has been concluded and put into effect as of today (Press release, Chugai, JUL 21, 2022, View Source [SID1234616835]).

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Although Chugai is majority-owned and subject to the consolidated results of Roche, as an independent, publicly listed company, Chugai makes all decisions based on the principles of self-governance. With regard to the trading of Chugai shares, the two companies had agreed to maintain Chugai shares to be listed on the first section of the Tokyo Stock Exchange even after ten years (from October 1, 2012) following the merger.

Following the revision of the market classification on the Tokyo Stock Exchange, new listing criteria were established for the Prime Market, which commenced operations on April 4, 2022. Accordingly, Chugai and Roche have made relevant revisions in light of the current situation while inheriting the basic spirit of the agreement.

The main revisions to the Basic Alliance Agreement are as follows:

Roche will cooperate in maintaining Chugai’s listing on the Prime Market1 of the Tokyo Stock Exchange.
In the event that Chugai issues shares, etc., Roche has the pre-emptive right to acquire the shares at the same price and under the same conditions as a third party, in order to maintain its current and future shareholding ratio in Chugai2.
1: Revised from "first section"
2: Revised from "50.1%"
Under the WIN-WIN strategic alliance with Roche, Chugai is promoting the growth strategy "TOP I 2030" with the aim of becoming a top innovator in the global healthcare industry as a listed company on the Prime Market of the Tokyo Stock Exchange. This matter has no impact on Chugai’s consolidated financial results for the fiscal year ending December 2022.

F. Hoffmann-La Roche Announces Half Year Results 2022

On July 21, 2022 F. Hoffmann-La Roche Ltd. (hereafter "Roche") [Head Office: Basel, Switzerland. CEO: Severin Schwan] reported its half year results 2022 (January 1 – June 30, 2022) (Press release, Chugai, JUL 21, 2022, View Source [SID1234616834]).

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Roche owns 59.89% of Chugai’s outstanding shares (61.14% of voting rights) as of the end of June 2022.

Its investor update and presentation materials can be found on its website (View Source).
Chugai’s performance for the period of January 1 to June 30, 2022 is included in the announced Roche Group’s results.

Cerus Corporation to Release Second Quarter 2022 Financial Results on August 4, 2022

On July 21, 2022 Cerus Corporation (Nasdaq: CERS) reported that its second quarter 2022 financial results will be released on Thursday, August 4, 2022, after the close of the stock market (Press release, Cerus, JUL 21, 2022, View Source [SID1234616833]). The Company will host a conference call and webcast at 4:30 P.M. ET that afternoon, during which management will discuss the Company’s financial results and provide a general business overview and outlook.

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To listen to the live webcast and view the presentation slides, please visit the Investor Relations page of the Cerus website at View Source Participants may register for the call here. While not required, interested participants are encouraged to join 10 minutes prior to the start of the event.

A replay will be available on Cerus’ website and will be available approximately three hours after the call through August 18, 2022.

Arbutus to Report Second Quarter 2022 Financial Results and Provide Corporate Update

On July 21, 2022 Arbutus Biopharma Corporation (Nasdaq: ABUS), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, reported that it has scheduled its second quarter 2022 financial results and corporate update for Thursday, August 4, 2022 (Press release, Arbutus Biopharma, JUL 21, 2022, View Source [SID1234616832]). The schedule for the press release and conference call/webcast are as follows:

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•Q2/2022 Press Release: Thursday, August 4, 2022 at 7:30 a.m. ET
•Q2/2022 Conference Call/Webcast: Thursday, August 4, 2022 at 8:45 a.m. ET
•Domestic Dial-In Number: (800) 715-9871
•International Dial-In Number: (646) 307-1963
•Conference ID Number: 5109143
A live webcast of the conference call can be accessed through the Investors section of Arbutus’ website at www.arbutusbio.com.

An archived webcast will be available on the Arbutus website after the event. Alternatively, you may access a replay of the conference call by calling (800) 770-2030 or (609) 800-9909, and reference conference ID: 5109143.

High-Yield GMP-Compliant Primary Cell Bank Established for Miltuximab®

On July 21, 2022 GlyTherix reported the successful completion of its high-yield GMP-grade stable cell line development program for its proprietary antibody Miltuximab in partnership with international biologics manufacturer GenScript ProBio (New Jersey, USA) (Press release, Glytherix, JUL 21, 2022, View Source [SID1234616831]).

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Establishing a stable, high-yield cell line suitable for commercial production of clinical-grade monoclonal antibody is a critical milestone for the Company. The Chinese Hamster Ovary (CHO) cell clones selected for Miltuximab cell banking have reached titres of above 8g/L. Work is now continuing on the process development program for scale-up of Miltuximab manufacturing at 100L-bioreactor scale for the Company’s upcoming Australian Phase I trial.

Miltuximab will be used in a Phase Ib trial as an antibody theranostic. Antibody labelled with 89-Zirconium will be used as an imaging agent to select patients showing tumor targeting. This will be followed by patients being offered Miltuximab labelled with 177-Lutetium as a therapeutic dose.

To find out more about GlyTherix’s technology and clinical program, visit www.glytherix.com

GlyTherix is seeking investors who would like to participate in the company’s Series A funding round.

This project received grant funding from the Australian Government.