On October 30, 2025 SOTIO Biotech, a clinical-stage biopharmaceutical company owned by PPF Group, reported it will present new preclinical and translational data from multiple investigational programs at two scientific conferences in November – the World ADC Conference in San Diego, California, and PEGS Europe, in Lisbon, Portugal.
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At these global forums, SOTIO will highlight progress across its next-generation antibody-drug conjugates (ADCs) and immunocytokine pipeline, which is advancing toward new treatment options for patients with solid tumors in areas of unmet medical need. Topics of the presentations include:
SOT106, a novel ADC targeting LRRC15 for the treatment of mesenchymal tumors, with a particular focus on soft tissue sarcoma and osteosarcoma. Preclinical data demonstrate a high therapeutic index and strong anti-tumor activity, supporting its potential best-in-class profile.
SOT109, SOTIO’s lead CDH17-targeting ADC for gastrointestinal cancers, including colorectal and other GI malignancies. Preclinical findings show robust efficacy and a favorable safety profile, reinforcing best-in-class therapeutic potential.
SOT201, a cis-acting PD-1/IL-15 mutein-based immunocytokine designed to target and reinvigorate exhausted T cells in the tumor microenvironment while maintaining a systemic immune balance. SOT201 is currently under clinical evaluation in the Phase 1 VICTORIA-01 study in patients with advanced metastatic cancers.
"These data reflect the significant progress we are making across our pipeline and the strength of our scientific foundation," said Radek Špíšek, M.D., Ph.D., chief executive officer of SOTIO. "By integrating deep insights into cancer biology with next-generation therapeutic modalities, we aim to provide new therapies for diseases with high unmet medical need."
World ADC oral presentation details:
Title: "Exploring Novel Pharmacology & Translational Aspects of SOT106 Targeting LRRC15 in Solid Tumors"
Session: Pharmacology track
Presenter: Lenka Palova Jelinkova
Date & Time: November 3, 2025, 10:30am PT
Title: "Advancing a Preclinical Pipeline of ADCs Targeting Gastrointestinal Cancers"
Session: Preclinical track
Presenter: Amy Jensen-Smith
Date & Time: November 5, 2025, 3:00pm PT
PEGS Europe oral presentation details:
Keynote Presentation Title: "SOT109: A CDH17 Targeting ADC with Best-in-Class Potential Activity for the Treatment of CRC and Other GI Cancers"
Session: Engineering Antibody-Drug Conjugates
Presenter: Radek Špíšek
Date & Time: November 12, 2025, 1:50pm CET
Title: "Preclinical Pharmacology and Translational Aspects of a Cis-Acting PD-1/IL-15 Mutein-Based Immunocytokine SOT201"
Session: Next-Generation Immunotherapies
Presenter: Anna Jirovec
Date & Time: November 13, 2025, 5:10pm CET
Presentation materials will be available upon request following the live presentations.
(Press release, SOTIO, OCT 30, 2025, View Source [SID1234657189])