On March 10, 2021 Curis, Inc. (NASDAQ: CRIS), a biotechnology company focused on the development of innovative therapeutics for the treatment of cancer, reported that an abstract for CA-4948, a small molecule IRAK4 inhibitor, has been accepted for poster presentation at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, which will be held virtually from April 10-15, 2021 (Press release, Curis, MAR 10, 2021, View Source [SID1234576439]).

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Details of the presentation are as follows:

Poster Presentation

Title: Identification of NF-kappaB phospho-p50 as a Potential Predictive Biomarker for IRAK4 inhibitor CA-4948 in Patients with Non-Hodgkin’s Lymphoma
Session Name: Biomarkers Predictive of Therapeutic Benefit
Session Date: Saturday, April 10, 2021
Additional meeting information can be found on the AACR (Free AACR Whitepaper) website View Source The presentation will also be available under "Events and Presentations" in the Investors section of the Company’s website at www.curis.com.

On March 10, 2021 Blueprint Medicines Corporation (NASDAQ: BPMC) reported plans to present new data for multiple research- and clinical-stage programs across the company’s precision oncology and hematology portfolio at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021 (Press release, Blueprint Medicines, MAR 10, 2021, View Source [SID1234576438]). Collectively, the planned data presentations will highlight the potential of Blueprint Medicines’ precision therapies to deliver transformative benefits to broad patient populations with systemic mastocytosis, non-small cell lung cancer and cyclin E-aberrant cancers.

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"At the AACR (Free AACR Whitepaper) annual meeting, we will present a wide range of preclinical and clinical data that highlights our ability to rapidly and reproducibly interrogate disease biology, design highly selective and potent precision therapies, and advance clinical development to address urgent patient needs," said Fouad Namouni, M.D., President, Research & Development at Blueprint Medicines. "Among multiple notable presentations, we plan to share for the first time new preclinical data highlighting the potential of BLU-701, a selective and potent double-mutant EGFR inhibitor, to become a cornerstone of our efforts in lung cancer and the potential of our research program targeting CDK2 to address a variety of patient populations with cancers harboring primary or acquired cyclin E aberrations."

Blueprint Medicines will host an investor conference call to discuss the data presented at AACR (Free AACR Whitepaper), and will provide webcast timing and dial-in information in advance of the meeting.

The accepted abstract titles are listed below and available on the AACR (Free AACR Whitepaper) conference website: View Source

Oral Presentation

Presentation Title: PATHFINDER: Interim analysis of avapritinib (ava) in patients (pts) with Advanced Systemic Mastocytosis (AdvSM)
Session Title: Molecular Targeted Agents in the Clinic
Session Date & Time: Sunday, April 11, 2021 from 2:00 – 4:00 p.m. ET
Abstract Number: CT023

Poster Presentations

Presentation Title: BLU-701 is a highly potent, brain-penetrant and WT-sparing next-generation EGFR TKI for the treatment of sensitizing (ΔEx19, L858R) and C797S resistance mutations in metastatic NSCLC
Session Title: Novel Antitumor Agents
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: 1262

Presentation Title: BLU-945, a fourth-generation, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with intracranial activity, demonstrates robust in vivo antitumor activity in models of osimertinib-resistant non-small cell lung cancer (NSCLC)
Session Title: Tyrosine Kinase and Phosphatase Inhibitors
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: 1467

Presentation Title: Development of a selective CDK2-E inhibitor in CCNE driven cancers
Session Title: Novel Antitumor Agents
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: 1279

Presentation Title: MAP4K1 inhibition enhances immune cell activation and anti-tumor immunity in preclinical tumor models
Session Title: Immunomodulatory Agents and Interventions
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: 1717

Presentation Title: Changes in mast cell (MC) numbers and phenotype in patients (pts) with indolent systemic mastocytosis (ISM) treated with avapritinib
Session Title: Phase II Clinical Trials
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: CT168

Presentation Title: Safety and pharmacokinetics of BLU-263, a next-generation KIT inhibitor, in normal healthy volunteers
Session Title: Phase I Clinical Trials
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: CT122

On March 10, 2021 Mirati Therapeutics, Inc. (NASDAQ: MRTX), a late-stage targeted oncology company, reported it will present initial preclinical data on the Company’s synthetic lethal PRMT5 inhibitor during a late-breaking minisymposium at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting taking place April 10-15, 2021 (Press release, Mirati, MAR 10, 2021, View Source [SID1234576437]).

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"At Mirati, we are applying leading-edge drug discovery strategies, such as synthetic lethality, to translate this exciting research approach into meaningful, targeted therapeutic options for patients with cancer," said James Christensen, Ph.D., executive vice president and chief scientific officer, Mirati Therapeutics, Inc. "We look forward to presenting early preclinical data at AACR (Free AACR Whitepaper) from our internally-discovered, potentially first-in-class, synthetic lethal PRMT5 inhibitor, as an example of how Mirati is progressing the science of novel targets."

Mirati is developing a novel synthetic lethal PRMT5 inhibitor targeting the methylthioadenosine phosphorylase (MTAP)-deleted patient population. Deletions of the MTAP gene locus are commonly observed in pancreatic, lung, and bladder cancers, among others, and are linked to poor patient outcomes. PRMT5 is an enzyme critical to the survival of normal and tumor cells and is partially inhibited by methylthioadenosine (MTA) which accumulates in MTAP-deleted cancers. Mirati’s differentiated approach selectively targets the PRMT5/MTA complex in MTAP-deleted cancer cells while sparing normal cells and represents a precision medicine strategy.

Presentation Details

Title: Fragment based discovery of MRTX9768, a synthetic lethal-based inhibitor designed to bind the PRMT5/MTA complex and selectively target MTAP/CDKN2A-deleted tumors
Author: Matthew Marx, Ph.D., senior vice president, drug discovery, Mirati Therapeutics, Inc.
Abstract #: LB003
Late-Breaking Minisymposium 1
Saturday, April 10, 2021, 1:30 p.m. – 3:30 p.m.

On March 10, 2021 Ascentage Pharma (6855.HK), a globally focused, clinical-stage biotechnology company engaged in developing novel therapies for cancers, chronic hepatitis B (CHB), and age-related diseases, reported that the latest preclinical research results of the company’s five novel drug candidates have been selected for presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021, and have already been published in the meeting’s official website (Press release, Ascentage Pharma, MAR 10, 2021, View Source [SID1234576436]). This year’s AACR (Free AACR Whitepaper) annual meeting will be held in a virtual format on April 27-28 and June 22-24.

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The AACR (Free AACR Whitepaper) annual meeting is one of the world’s largest and long-standing scientific gatherings in the field of cancer research. Covering some of the most cutting-edge advances in all the areas of oncology research and innovation, the annual event attracts tremendous interest from the global cancer research community.

"It is our great pleasure to have the research results of our drug candidates selected by the AACR (Free AACR Whitepaper) annual meeting several years in a row, and this year, our presentations will focus on results from the translational research of multiple drug candidates that have already entered into clinical development," said Dr. Yifan Zhai, Chief Medical Officer of Ascentage Pharma. "These studies deepened our understanding of our drug candidate’s mechanism of actions, provided supportive evidence to our strategy for combination options and potential disease indications, and have therefore further advanced our clinical development of these therapeutic candidates."

The six abstracts selected for poster presentations at the AACR (Free AACR Whitepaper) Annual Meeting 2021 include:

Title:

BCL-2 inhibitor APG-2575 and homoharringtonine (HHT) synergistically induces apoptosis and inhibits tumor growth in preclinical models of acute myeloid leukemia and myelodysplastic syndromes (AML/MDS)

Abstract/Poster Number: 981
Session Category: Experimental and Molecular Therapeutics
Session Title: Cell Death Pathways and Treatment
Title:

Inhibition of BCL-2 (by APG-2575) and CDK4/6 synergistically induces cell cycle arrest and apoptosis in ER⁺ breast cancer

Abstract/Poster Number: 976
Session Category: Experimental and Molecular Therapeutics
Session Title: Cell Death Pathways and Treatment
Title:

FMS-like tyrosine kinase 3 (FLT3) inhibition by olverembatinib (HQP1351) downregulates MCL-1 and synergizes with BCL-2 inhibitor APG-2575 in preclinical models of FLT3-mutant acute myeloid leukemia (AML)

Abstract/Poster Number: 1096
Session Category: Experimental and Molecular Therapeutics
Session Title: Drug Resistance in Molecular Targeted Therapies
Title:

Therapeutic potential of inhibitor of apoptosis protein (IAP) inhibitor APG-1387 combined with DR5 agonist monoclonal antibody (mAb) CTB-006 in preclinical models of solid tumors

Abstract/Poster Number: 1924
Session Category: Molecular and Cellular Biology / Genetics
Session Title: Apoptosis
Title:

Targeting BCL-xL addiction with APG-1252 (pelcitoclax) to overcome apoptotic blockade in neuroendocrine neoplasm (NEN)

Abstract/Poster Number: 984
Session Category: Experimental and Molecular Therapeutics
Session Title: Cell Death Pathways and Treatment
Title:

Focal adhesion kinase (FAK) inhibitor APG-2449 sensitizes ovarian tumors to chemotherapy via CD44 downregulation

Abstract/Poster Number: 968
Session Category: Experimental and Molecular Therapeutics
Session Title: Biological Therapeutic Agents

On March 10, 2021 Xencor, Inc. (NASDAQ: XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies and cytokines for the treatment of cancer and autoimmune diseases, reported it will present preclinical data on three XmAb bispecific antibody programs and the IL-12-Fc cytokine program at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, being held virtually April 10-15, 2021 (Press release, Xencor, MAR 10, 2021, View Source [SID1234576433]). Abstracts for these poster presentations are now available on AACR (Free AACR Whitepaper)’s website.

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Poster Presentation Details

Abstract 1743, "IL12 heterodimeric Fc-fusions engineered for reduced potency exhibit strong anti-tumor activity and improved therapeutic index compared to native IL12 agents"
Session: Immunomodulatory Agents and Interventions
Abstract: 1880, "PDL1-targeted CD28 costimulatory bispecific antibodies enhance T cell activation in solid tumors"
Session: Therapeutic Antibodies, Including Engineered Antibodies
Abstract: 1860, "Bispecific claudin-6 x CD3 antibodies in a 2+1 format demonstrate selectivity and activity on human ovarian cancer cells"
Session: Therapeutic Antibodies, Including Engineered Antibodies
Abstract: 1831, "Affinity tuned XmAb 2+1 GPC3 x CD3 bispecific antibodies demonstrate selective activity in liver cancer models"
Session: Therapeutic Antibodies, Including Engineered Antibodies
These posters will be available to registrants of the AACR (Free AACR Whitepaper) Annual Meeting at 8:30 a.m. EDT on Saturday, April 10. Posters will be archived under "Events & Presentations" in the Investors section of the Company’s website located at www.xencor.com.