On February 5, 2018 BeiGene, Ltd. (NASDAQ:BGNE), a commercial-stage biopharmaceutical company focused on developing and commercializing innovative molecularly targeted and immuno-oncology drugs for the treatment of cancer, reported that it will present preliminary Phase I data on its investigational anti-PD-1 antibody, tislelizumab, in urothelial carcinoma (bladder cancer) at the upcoming 2018 Genitourinary Cancers Symposium, to be held February 8-10 in San Francisco (Press release, BeiGene, FEB 5, 2018, View Source;p=RssLanding&cat=news&id=2330396 [SID1234523733]).
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Poster Title: Preliminary Results from Patients with Urothelial Carcinoma (UC) in a Phase 1A/1B study of BGB-A317, an Anti-PD-1 Monoclonal Antibody
Abstract: 445; Poster Board: G16
Presenter: Shahneen Sandhu, M.D.
Poster Session B: Prostate Cancer, Urothelial Carcinoma, and Penile, Urethral, and Testicular Cancers
Date & Times: Friday, February 9, 2018 at 12:15-1:45 PM (PT) and 6:00-7:00 PM (PT)
Location: Moscone West Building, San Francisco
About Tislelizumab (BGB-A317)
Tislelizumab is an investigational humanized monoclonal antibody that belongs to a class of immuno-oncology agents known as immune checkpoint inhibitors. It is designed to bind to PD-1, a cell surface receptor that plays an important role in downregulating the immune system by preventing the activation of T-cells. Tislelizumab has demonstrated high affinity and specificity for PD-1. It is differentiated from the currently approved PD-1 antibodies in an engineered Fc region, which is believed to minimize potentially negative interactions with other immune cells. Tislelizumab is being developed as a monotherapy and in combination with other therapies for the treatment of a broad array of both solid tumor and hematologic cancers. BeiGene and Celgene Corporation have a global strategic collaboration for tislelizumab for solid tumors outside of Asia (except Japan).