On November 1, 2017 Bellicum Pharmaceuticals, Inc. (Nasdaq:BLCM), a leader in developing novel, controllable cellular immunotherapies for cancers and orphan inherited blood disorders, reported that four abstracts, including an oral presentation on the Company’s lead product candidate BPX-501, were accepted for presentation at the 59th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting (Press release, Bellicum Pharmaceuticals, NOV 1, 2017, View Source [SID1234521398]).

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In the oral presentation, Pietro Merli of Ospedale Pediatrico Bambino Gesù in Rome, Italy will review data from the ongoing EU BP-004 study, highlighting rapid immune recovery in pediatric patients with blood cancers, immune deficiencies and other non-malignant disorders receiving treatment with BPX-501 following an alpha/beta-depleted haploidentical hematopoietic stem cell transplant. The Company will also present data highlighting preclinical results of its controllable CAR-T technology in three poster presentations, including a study evaluating Bellicum’s dual-switch CAR-T cells targeting CD123. ASH (Free ASH Whitepaper) 2017 is being held in Atlanta, Georgia on December 9-12.

ASH Presentations on Bellicum Programs

BPX-501:

Oral Presentation: “Donor T Cells Genetically Modified with a Novel Suicide Gene (Inducible Caspase 9, iC9) Expand and Persist Over Time After Post-Allograft Infusion in Patients Given αβ T-Cell and B-Cell Depleted HLA-Haploidentical Allogeneic Stem Cell Transplantation (αβ Haplo-HSCT) Contributing to Accelerate Immune Recovery”
Abstract Number: 211
Session Name: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution: Prevention
Session Date: Saturday, December 9, 2017
Session Time: 2:00 p.m. – 3:30 p.m. EST
Presentation Time: 2:00 p.m. EST

Controllable CAR-T Technology:

Poster Presentation: “Dual-Switch CAR-T Cells: Orthogonal Molecular Switches to Control Activation and Elimination of CAR-T Cells to Target CD123+ Cancer”
Abstract Number: 3184
Session Name: 703. Adoptive Immunotherapy: Poster II
Date: Sunday, December 10, 2017
Presentation Time: 6:00 p.m. – 8:00 p.m. EST

Poster Presentation: “Inducible MyD88/CD40 (iMC) Costimulation Enhances Polyclonal Epstein-Barr Virus-Specific Cytotoxic T Lymphocyte (EBV-CTL) Proliferation and Anti-Tumor Activity”
Abstract Number: 3337
Session Name: 801. Gene Therapy and Transfer: Poster II
Date: Sunday, December 10, 2017
Presentation Time: 6:00 p.m. – 8:00 p.m. EST

Poster Presentation: “MyD88/CD40 Enhanced CD19-Specific CAR-T Cells Maintain Therapeutic Efficacy Following Resolution of Cytokine-Related Toxicity Using Inducible Caspase-9”
Abstract Number: 4615
Session Name: 801. Gene Therapy and Transfer: Poster III
Date: Monday, December 11, 2017
Presentation Time: 6:00 p.m. – 8:00 p.m. EST