On November 10, 2022 Beyond Cancer, Ltd., an affiliate of Beyond Air, Inc. (NASDAQ: XAIR) that is focused on developing ultra-high concentration nitric oxide (UNO) for the treatment of solid tumors, reported promising new in vivo combination data that support the potential of the company’s novel gaseous nitric oxide (gNO) therapy to treat various types of solid tumors in combination with immune checkpoint inhibitor (ICI) therapies, including anti-PD-1 (Press release, Beyond Cancer, NOV 10, 2022, View Source [SID1234623764]). These data were published in an abstract by the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) and will be presented in a poster presentation today at the 37th Annual SITC (Free SITC Whitepaper) Meeting in Boston, MA.
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"The results presented this week offer an encouraging first look at the potential synergistic effect of ultra-high concentration nitric oxide (UNO) and anti-PD-1 therapy," stated Dr. Selena Chaisson, Chief Executive Officer and Director. "Immunotherapies are a cornerstone in current treatment options for tumors, and we are excited to see these in vivo data show the ability of a single treatment of UNO when used in combination with anti-PD-1 have a positive impact on tumor regression rates and overall survival. We believe these promising data provide a strong rationale for the continued advancement of this program in combination with immune checkpoint therapies."
"Our previous work has shown the ability of UNO therapy to impart an immune response that is capable of preventing metastases in mice with CT26," stated Hila Confino, Chief Scientific Officer of Beyond Cancer. "Our combination data presented today at the SITC (Free SITC Whitepaper) 2022 Annual Meeting show an effect on the primary tumor and, importantly, can treat metastatic disease and not just prevent it. We look forward to presenting further details on the ability of UNO to stimulate an anti-cancer immune response."
The poster presentation detailing the in vivo combination data presented at the SITC (Free SITC Whitepaper) 2022 Annual Meeting is titled, "Intratumoral Administration of High-Concentration Nitric Oxide and Anti PD-1 Treatment Leads to Higher Tumor Regression Rates and Prolonged Survival in CT26 Tumor-Bearing Mice" (abstract 819). The ePoster with accompanying slides and audio are available on the company’s website (click here).
Details of the Company’s presentation are as follows:
Title: Intratumoral Administration of High-Concentration Nitric Oxide and Anti PD-1 Treatment Leads to Higher Tumor Regression Rates and Prolonged Survival in CT26 Tumor-Bearing Mice
Location: Boston Convention & Exhibition Center, Exhibit Hall C, Abstract 819
Date: Thursday Nov 10, 2022 from 9 a.m.-9 p.m. EST
Participant: Hila Confino, Ph.D; Chief Scientific Officer, Beyond Cancer, Ltd.
About Nitric Oxide (NO)
Nitric Oxide (NO) is a powerful molecule, naturally synthesized in the human body, proven to play a critical role in a broad array of biological functions. Currently, exogenous inhaled NO is used in adult respiratory distress syndrome, post certain cardiac surgeries, and persistent pulmonary hypertension of the newborn to treat hypoxemia. Additionally, NO is believed to play a key role in the innate and adaptive immune system response and in vitro studies suggest that NO possesses broad-spectrum antimicrobial activity and anticancer properties.