On May 13, 2020 Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, reported that a poster describing the design of the ongoing Phase I/II trial of BT5528 will be presented during an e-poster session at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2020 Virtual Scientific Program on May 29-31, 2020 (Press release, Bicycle Therapeutics, MAY 13, 2020, View Source [SID1234557924]). BT5528 is a second-generation Bicycle Toxin Conjugate (BTC) that targets EphA2, a tumor antigen that is overexpressed in a wide range of solid tumor types and is associated with poor outcomes.
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"To our knowledge, BT5528 is one of a very few toxin conjugates that target EphA2 currently being evaluated in clinical studies, despite literature indicating that EphA2 is an attractive target for selective payload delivery," said Kevin Lee, Ph.D., Chief Executive Officer of Bicycle Therapeutics. "Other EphA2-targeting toxin conjugates using biologics have been investigated but ultimately discontinued due to poor tolerability. Leveraging the unique features of Bicycles, we designed BT5528 to have a pharmacokinetic profile that could allow it to circumvent limitations of prior, unsuccessful efforts to target EphA2. We recently announced that, to date, doses of BT5528 administered in the ongoing Phase I/II trial in patients with advanced solid tumors associated with EphA2 expression continue to appear well-tolerated with manageable adverse events as dosing nears clinically relevant levels. We are excited by the progress we’re making in the trial and look forward to discussing its design at ASCO (Free ASCO Whitepaper)."
Details on Bicycle’s poster presentation at ASCO (Free ASCO Whitepaper) are as follows:
Session Title: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology Session
Poster Title: BT5528-100 phase I/II study of the safety, pharmacokinetics, and preliminary clinical activity of BT5528 in patients with advanced malignancies associated with EphA2 expression
Abstract #: TPS3655
Session Date and Time: Friday, May 29, 2020 at 8:00 a.m. ET
The poster will be available on the Publications section of bicycletherapeutics.com following presentation.