On April 22, 2021 Bio-Path Holdings, Inc., (NASDAQ: BPTH) a biotechnology company leveraging its proprietary DNAbilize antisense RNAi nanoparticle technology to develop a portfolio of targeted nucleic acid cancer drugs, reported the publication of an analysis highlighting the potential of prexigebersen (BP1001) within the antisense oligonucleotide drug delivery landscape in the peer-reviewed journal, Biomedicines (Press release, Bio-Path Holdings, APR 22, 2021, View Source [SID1234578429]).

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The article, titled "The Challenges and Strategies of Antisense Oligonucleotide Drug Delivery," describes the challenges facing the antisense oligonucleotide drug delivery landscape, including stability in the bloodstream, delivery to target sites, and cellular uptake. In addition, the authors outline why prexigebersen, a liposome-incorporated antisense oligodeoxynucleotide targeted against the Grb2 mRNA, has the potential to overcome these challenges.

The article was authored by Maria Gagliardi, Ph.D., Research Scientist at Bio-Path Holdings and Ana Tari Ashizawa, Ph.D., Senior Vice President of Research, Development and Clinical Design at Bio-Path Holdings.

"We believe prexigebersen has the potential to overcome the challenges of antisense oligonucleotide drug delivery because it is uncharged and is essentially non-toxic, as demonstrated in preclinical and clinical studies. Additionally, its enhanced biodistribution makes it an attractive therapeutic modality for hematologic malignancies as well as solid tumors," said Dr. Ashizawa.