On April 26, 2023 Blueprint Medicines Corporation (NASDAQ: BPMC) reported the acceptance of clinical abstracts for multiple programs across its precision therapy portfolio at the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, June 2 to 6 (Press release, Blueprint Medicines, APR 26, 2023, View Source [SID1234630553]). The presentations showcase Blueprint Medicines’ next wave of therapeutic candidates in its robust clinical pipeline, and highlight ongoing progress as the company seeks to pioneer innovative combination strategies and advance development of its programs into earlier lines of treatment.

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The datasets to be reported at the ASCO (Free ASCO Whitepaper) Annual Meeting include:

Results from the ongoing dose escalation part of the VELA trial of BLU-222 in breast cancer and other cancers vulnerable to CDK2 inhibition, showing evidence of monotherapy safety and pathway modulation.

Updated results from the dose escalation part of the SYMPHONY trial showing the safety and tolerability of BLU-945 as a monotherapy and in combination with osimertinib in patients with late-line, EGFR-mutant non-small cell lung cancer (NSCLC).

Results from the ongoing dose escalation part of the CONCERTO trial of BLU-451 in EGFR exon 20 insertion-positive NSCLC showing early safety and clinical activity.
"These upcoming presentations reflect important clinical progress toward realizing the promise of our innovative precision therapies to help address complex medical needs in lung and breast cancer, leveraging our scientific and development expertise with the goal of overcoming traditional limitations of targeted therapy," said Becker Hewes, M.D., Chief Medical Officer at Blueprint Medicines. "Collectively, the datasets represent another step toward achieving our 2027 Blueprint for Precision at Scale – our five-year growth strategy to reach broad patient populations through the development of transformative precision therapies."

The accepted abstracts are listed below, and abstract titles are available today on the ASCO (Free ASCO Whitepaper) conference website: meetings.asco.org.

Data Presentations

Poster Presentation Title: BLU-222, an oral, potent and selective CDK2 inhibitor, in patients with advanced solid tumors: phase 1 monotherapy dose escalation
Session Title: Developmental Therapeutics—Molecularly Targeted Agents and Tumor Biology
Session Date & Time: Saturday, June 3, 2023 from 8:00 a.m. — 11:00 a.m. CT (9:00 a.m. — 12:00 p.m. ET)
Abstract Number: 3095
Location: Hall A

Poster Presentation Title: Emerging phase 1 data of BLU-451 in advanced NSCLC with EGFR exon 20 insertions
Session Title: Lung Cancer—Non-Small Cell Metastatic
Session Date & Time: Sunday, June 4, 2023 from 8:00 a.m. — 11:00 a.m. CT (9:00 a.m. — 12:00 p.m. ET)
Abstract Number: 9064
Location: Hall A

Short Oral Presentation Title: BLU-945 monotherapy and in combination with osimertinib (OSI) in previously treated patients with advanced EGFR-mutant (EGFRm) NSCLC in the phase 1/2 SYMPHONY study
Session Title: Rapid Abstract Session: Lung Cancer
Session Date & Time: Monday, June 5, 2023 from 11:30 a.m. — 12:30 p.m. CT (12:30 p.m. — 1:30 p.m. ET)
Abstract Number: 9011
Location: S406