On March 10, 2021 Blueprint Medicines Corporation (NASDAQ: BPMC) reported plans to present new data for multiple research- and clinical-stage programs across the company’s precision oncology and hematology portfolio at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2021 (Press release, Blueprint Medicines, MAR 10, 2021, View Source [SID1234576438]). Collectively, the planned data presentations will highlight the potential of Blueprint Medicines’ precision therapies to deliver transformative benefits to broad patient populations with systemic mastocytosis, non-small cell lung cancer and cyclin E-aberrant cancers.

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"At the AACR (Free AACR Whitepaper) annual meeting, we will present a wide range of preclinical and clinical data that highlights our ability to rapidly and reproducibly interrogate disease biology, design highly selective and potent precision therapies, and advance clinical development to address urgent patient needs," said Fouad Namouni, M.D., President, Research & Development at Blueprint Medicines. "Among multiple notable presentations, we plan to share for the first time new preclinical data highlighting the potential of BLU-701, a selective and potent double-mutant EGFR inhibitor, to become a cornerstone of our efforts in lung cancer and the potential of our research program targeting CDK2 to address a variety of patient populations with cancers harboring primary or acquired cyclin E aberrations."

Blueprint Medicines will host an investor conference call to discuss the data presented at AACR (Free AACR Whitepaper), and will provide webcast timing and dial-in information in advance of the meeting.

The accepted abstract titles are listed below and available on the AACR (Free AACR Whitepaper) conference website: View Source

Oral Presentation

Presentation Title: PATHFINDER: Interim analysis of avapritinib (ava) in patients (pts) with Advanced Systemic Mastocytosis (AdvSM)
Session Title: Molecular Targeted Agents in the Clinic
Session Date & Time: Sunday, April 11, 2021 from 2:00 – 4:00 p.m. ET
Abstract Number: CT023

Poster Presentations

Presentation Title: BLU-701 is a highly potent, brain-penetrant and WT-sparing next-generation EGFR TKI for the treatment of sensitizing (ΔEx19, L858R) and C797S resistance mutations in metastatic NSCLC
Session Title: Novel Antitumor Agents
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: 1262

Presentation Title: BLU-945, a fourth-generation, potent and highly selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) with intracranial activity, demonstrates robust in vivo antitumor activity in models of osimertinib-resistant non-small cell lung cancer (NSCLC)
Session Title: Tyrosine Kinase and Phosphatase Inhibitors
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: 1467

Presentation Title: Development of a selective CDK2-E inhibitor in CCNE driven cancers
Session Title: Novel Antitumor Agents
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: 1279

Presentation Title: MAP4K1 inhibition enhances immune cell activation and anti-tumor immunity in preclinical tumor models
Session Title: Immunomodulatory Agents and Interventions
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: 1717

Presentation Title: Changes in mast cell (MC) numbers and phenotype in patients (pts) with indolent systemic mastocytosis (ISM) treated with avapritinib
Session Title: Phase II Clinical Trials
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: CT168

Presentation Title: Safety and pharmacokinetics of BLU-263, a next-generation KIT inhibitor, in normal healthy volunteers
Session Title: Phase I Clinical Trials
Session Date & Time: Saturday, April 10, 2021 at 8:30 a.m. ET
Abstract Number: CT122