On May 19, 2020 BostonGene Corporation, a biomedical software company focused on defining optimal, precision medicine-based therapies for cancer patients, reported that, as a result of its strategic collaborations, seven abstracts have been accepted to the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting (Press release, BostonGene, MAY 19, 2020, View Source [SID1234558290]). All abstracts to be published in the Journal of Clinical Oncology supplement for the ASCO (Free ASCO Whitepaper) Annual Meeting Proceedings.

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"We are honored to have multiple abstracts accepted by ASCO (Free ASCO Whitepaper) 2020. The studies demonstrate the clinical utility of BostonGene‘s advanced precision medicine capabilities and our commitment to transform the lives of cancer patients," said Andrew Feinberg, President & CEO at BostonGene.

Details of abstract presentations are as follows:

1.Abstract Number: 8055*

Title: "Multi-omics analysis of mantle cell lymphoma reveals an immune-cold tumor microenvironment associated with ibrutinib resistance"

Session: Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Presenter: Krystle Nomie, PhD, BostonGene

Poster: 388

Tumor-immune molecular programs were characterized from over 200 mantle cell lymphoma samples and correlated with response to ibrutinib.

Research conducted with The University of Texas MD Anderson Cancer Center

2.Abstract Number: 6561*

Title: "Immune functional portraits of head and neck cancer using next generation sequencing"

Session: Head and Neck Cancer

Presenter: Susan Raju Paul, MBBS, Vaccine and Immunotherapy Center, Massachusetts General Hospital

Poster: 222

BostonGene’s comprehensive, integrated analysis of WES and RNAseq was used to characterize the cellular composition and functional state of over 1,400 head and neck tumors and their tumor microenvironment.

Research conducted with Massachusetts General Hospital

3.Abstract Number: 8054*

Title: "Identification of Predicted Neoantigen Vaccine Candidates in Follicular Lymphoma Patients"

Session Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Presenter: Cody Ramirez at Washington University in St Louis

Poster: 387

Tumor-specific mutant antigens (TSMAs) that can be targeted by vaccination were studied in follicular lymphoma patients and led to a first-in-human pilot trial of a personalized TSMA vaccine combined with immunotherapy.

Research conducted with Washington University in St Louis

4.Abstract Number: e20065

Title: "Correlation of PI3K upregulation with NOTCH2 mutations in ibrutinib-resistant mantle cell lymphoma"

First Author: Krystle Nomie, PhD, BostonGene

Research conducted with The University of Texas MD Anderson Cancer Center

5.Abstract Number: e21026

Title: "Non-small cell lung cancer: Analysis using mass cytometry and next generation sequencing reveals new opportunities for the development of personalized therapies"

First Author: Susan Raju Paul, MBBS, Vaccine and Immunotherapy Center, Massachusetts General Hospital

Research conducted with Massachusetts General Hospital

6.Abstract Number: e17106

Title: "Integrated single-cell spatial multi-omics of intratumor heterogeneity in renal cell carcinoma"

First Author: James Hsieh, MD, PhD at Washington University in St. Louis

Research conducted with Washington University in St Louis

7.Abstract Number: e17506

Title: "Integrated-omics of MRI-visible and -invisible prostate cancer identifies molecular correlations with clinical outcome"

First Author: Eric H. Kim, MD at Washington University in St. Louis

Research conducted with Washington University in St Louis

*Abstracts to be presented as posters at the 2020 ASCO (Free ASCO Whitepaper) Annual Virtual Meeting from May 29-31, 2020