On April 11, 2023 BostonGene reported that eight abstracts were selected for poster presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2023, which will be held from April 14 – 19, at the Orange County Convention Center in Orlando, FL. BostonGene will exhibit at booth #1358 (Press release, BostonGene, APR 11, 2023, View Source [SID1234629976]).

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On Sunday, April 16, Alexander Bagaev, PhD, Vice President of Product Development at BostonGene, will deliver a presentation on the power of next-generation immunotherapy response prediction driven by BostonGene’s bioinformatic engine through AI-based multiomic data integration.

BostonGene will present posters that describe the development of novel assays and analytical tools and pipelines to advance precision oncology, including our liquid biopsy platform and cancer of unknown primary (CUP) classifier. BostonGene will also demonstrate ability of comprehensive molecular profiling to identify clinically relevant alterations that can be utilized for treatment decision-making. The presentations highlight the application of BostonGene’s innovative technologies to improve the diagnosis and personalized treatment recommendations for cancer patients.

Details of BostonGene’s presence at the AACR (Free AACR Whitepaper) Annual Meeting are below:

Spotlight Theater Presentation:

Title: Next generation immunotherapy response prediction driven by BostonGene’s bioinformatic engine through AI-based multiomic data integration
Date and Time: Sunday, April 16 | 1:30 PM
Location: Spotlight theater C
Speaker: Alexander Bagaev, PhD, Vice President of Product Development, BostonGene

BostonGene uses artificial intelligence and machine learning systems to integrate data from next-generation DNA and RNA sequencing (NGS), multiplex imaging, and flow cytometry to paint a comprehensive portrait of a cancer patient’s tumor and immune system. This 360-degree approach to precision diagnostics requires the deployment of novel analytical solutions.

Poster Presentations:

Title: Use of comprehensive molecular profiling to identify additional clinically-relevant alterations compared to targeted gene panels
Abstract number: 244
Date and Time: Sunday, April 16 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 9
Presenter: Sandrine Degryse, PhD, BostonGene

Title: Analytical validation of a liquid biopsy test using cell-free circulating tumor DNA for mutational profiling
Abstract number: 1042
Date and Time: Sunday, April 16 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 42
Presenter: Anastasia Yudina, BostonGene

Title: Integrated analysis of gene expression signatures and AI-based detection of tertiary lymphoid structures and stromal tumor-infiltrating lymphocytes in breast cancer H&E samples
Abstract number: 27
Date and Time: Tuesday, April 18 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 33
Presenter: Kate Postovalova, PhD, BostonGene

Title: An ML-based tool for predicting tissue of origin for cancer of unknown primary (CUP) based on genomic and transcriptomic data
Abstract number: 5405
Date and Time: Tuesday, April 18 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 32
Presenter: Nara Shin, PhD, BostonGene

Title: Computational cancer cell gene expression deconvolution from tumor bulk RNA-seq via the machine learning algorithm Helenus
Abstract number: 5401
Date and Time: Tuesday, April 18 | 1:30 PM – 5:00 PM
Location: Exhibit Hall, Poster Section 32
Presenter: Krystle Nomie, PhD, BostonGene

Title: Development and refinement of functional gene expression signatures as a computational tool for comprehensive characterization of transcriptomic data
Abstract number: 6538
Date and Time: Wednesday, April 19 | 9:00 AM – 12:30 PM
Location: Exhibit Hall, Poster Section 30
Presenter: Alexander Bagaev, PhD, BostonGene

Title: Comprehensive immunoprofiling of peripheral blood reveals five conserved immunotypes with implications for immunotherapy in cancer patients
Abstract number: 6664
Date and Time: Wednesday, April 19 | 9:00 AM – 12:30 PM
Location: Exhibit Hall, Poster Section 39
Presenter: Michael Goldberg, PhD, BostonGene

Title: Cancer of unknown primary (CUP): Beyond the identification of the site of origin by an integrative genomic approach
Abstract number: 2143
Date and Time: Monday, April 17 | 9:00 AM – 12:30 PM
Location: Exhibit Hall, Poster Section 39
Presenter: Majd Al Assaad, MD, Weill Cornell Medicine

Research conducted in collaboration with Weill Cornell Medicine

The abstracts will be published in an online-only Proceedings supplement to the AACR (Free AACR Whitepaper) journal Cancer Research after the conclusion of the AACR (Free AACR Whitepaper) Annual Meeting.