On May 18, 2023 BridGene Biosciences, Inc., a biotechnology company using a proprietary chemoproteomics technology to discover and develop small molecules for high-value, traditionally undruggable targets, announced that Wolf Wiedemeyer, Ph.D., head of biology at BridGene, reported that it will be giving a presentation, titled "A Covalent TEAD Inhibitor with Exceptional Anti-cancer Activity & Combination Potential," at the 2nd Annual Hippo Pathway Targeted Drug Development Summit on May 24 in Boston (Press release, Bridgene Biosciences, MAY 18, 2023, View Source [SID1234631869]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The 2nd Annual Hippo Pathway Targeted Drug Development Summit is an industry-led forum, aimed at accelerating the understanding and opportunity of the Hippo signaling pathway in progressing the discovery, translation, and clinical development of safe and effective therapeutics within oncology, regenerative medicine, fibrosis, and beyond.

Dr. Wiedemeyer’s presentation will provide a preclinical update on a lead covalent TEAD inhibitor, including in vivo efficacy, harnessing TEAD selectivity to expand into TEADi-responsive indications and exploring combination approaches with KRAS inhibitors, which have shown promising results in clinical trials for cancer.

"Our IMTAC live-cell chemoproteomic platform to identify small molecules against challenging targets has successfully identified several potent and drug-like covalent ligands for TEAD and provided the foundation for BridGene to discover its pre-clinical oncology drug candidate BGI-9004," said CEO and Co-founder Ping Cao, Ph.D.

Details regarding the poster presentation are as follows:

Event:

2nd Annual Hippo Pathway Targeted Drug Development Summit

Title:

A Covalent TEAD Inhibitor with Exceptional Anti-cancer Activity &
Combination Potential

Date:

Wednesday, May 24, 2023

Time:

2:15 p.m. ET

Location:

Boston Park Plaza, Boston, Mass.