On May 11, 2023 Bristol Myers Squibb (NYSE: BMY) reported the presentation of data at the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, the European Hematology Association (EHA) (Free EHA Whitepaper) Congress, and the International Conference on Malignant Lymphoma (ICML), underscoring the company’s momentum towards delivering treatment options with the hope to transform clinical outcomes for patients (Press release, Bristol-Myers Squibb, MAY 11, 2023, View Source [SID1234631491]). Data from more than 160 company-sponsored studies, investigator-sponsored studies and collaborations evaluating compounds spanning 20 cancer types and serious blood disorders will be featured across the three meetings, including the COMMANDS study, which has been selected for the official ASCO (Free ASCO Whitepaper) press program (Abstract #7003) and EHA (Free EHA Whitepaper) plenary session (Abstract #S102).

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"We look forward to sharing our research during ASCO (Free ASCO Whitepaper), EHA (Free EHA Whitepaper) and ICML, demonstrating the diversity of our assets, cutting-edge pipeline, and science-driven strategy focused on shaping the next generation of cancer care," said Samit Hirawat, M.D., executive vice president, chief medical officer, Global Drug Development, Bristol Myers Squibb. "The breadth of data and results illustrate how we are leveraging novel technologies to develop therapies that disrupt the course of disease for patients with solid tumors, blood cancers, and blood disorders. Positive study outcomes are critical, and so is ensuring those results represent and can benefit a diverse population of patients. Our health equity commitments are enabling inclusive innovation, better science and greater reach of our medicines to the patients who need them most."

Key data being presented by Bristol Myers Squibb at ASCO (Free ASCO Whitepaper), EHA (Free EHA Whitepaper) and ICML 2023 include:

Hematology

First disclosure of data from the Phase 3 COMMANDS study of Reblozyl (luspatercept-aamt)versus epoetin alfa, an erythropoiesis-stimulating agent (ESA), demonstrated highly statistically significant and clinically meaningful improvement in patients with anemia associated with very low- to intermediate-risk myelodysplastic syndromes, who require red blood cell (RBC) transfusions and are ESA-naïve. (ASCO/EHA)

Preliminary results from the dose-escalation and expansion components of the Phase 1 CC-93269-MM-001 study demonstrate subcutaneous administration of bispecific T-cell engager alnuctamab exhibited promising dose-dependent anti-tumor activity in heavily pretreated multiple myeloma, with a high proportion of responders achieving minimal residual disease negativity. (EHA) (Free EHA Whitepaper)

Results from the dose-escalation components of a Phase 1/2 study evaluating BET inhibitor BMS-986158 as monotherapy and in combination with ruxolitinib or Inrebic (fedratinib), show generally manageable safety and robust spleen volume reduction in patients with intermediate- or high-risk myelofibrosis. (EHA) (Free EHA Whitepaper)

First disclosure of clinical data from a Phase 1b study evaluating golcadomide (CC-99282), a novel CELMoDTM agent, in combination with R-CHOP in patients with previously untreated aggressive B-cell lymphoma will be presented. (ICML)

Results from a dose-expansion cohort of the Phase 1/2 CC-92480-MM-001 study, evaluating novel CELMoD agent, mezigdomide, with dexamethasone in patients with relapsed/refractory multiple myeloma, showed the combination’s safety profile and promising efficacy in patients with triple-class refractory multiple myeloma. (EHA) (Free EHA Whitepaper)
Cell Therapy

First disclosure of data from the primary analysis of the TRANSCEND CLL 004 study of Breyanzi (lisocabtagene maraleucel) demonstrated deep and durable responses and a manageable safety profile, with no new safety signals, in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma. (ASCO) (Free ASCO Whitepaper)
Multiple analyses from the KarMMa-3 study showed improved health-related quality of life (HRQOL) and patient-reported outcomes, in addition to lower risk of disease progression, with Abecma (idecabtagene vicleucel), regardless of baseline high-risk disease or number of prior lines of therapy, in patients with triple-class exposed relapsed and refractory multiple myeloma. (ASCO/EHA)
Interim results from Phase 1 study of GPRC5D CAR T (BMS-986393/CC-95266) demonstrated durable responses with an overall generally manageable safety profile, including in patients with prior BCMA-directed therapy. (EHA) (Free EHA Whitepaper)
Solid Tumor

Results from the registrational TRIDENT-1 trial showed durable clinical activity with repotrectinib in ROS1 tyrosine kinase inhibitor (TKI)-naïve and TKI-pretreated patients with locally advanced or metastatic ROS1-positive NSCLC with or without baseline central nervous system metastases, including robust intracranial responses. (ASCO) (Free ASCO Whitepaper)
Four-year data from the Phase 3 CheckMate -9LA trial reinforce durable, long-term survival with Opdivo (nivolumab) plus Yervoy (ipilimumab) with two cycles of chemotherapy for patients with metastatic NSCLC, including subgroups with higher unmet needs. (ASCO) (Free ASCO Whitepaper)
Three-year results demonstrated long-term clinical benefit of neoadjuvant Opdivo with chemotherapy in patients with resectable NSCLC who received definitive surgery in the Phase 3 CheckMate -816 trial. (ASCO) (Free ASCO Whitepaper)
Biomarker analyses from the Phase 3 CheckMate -76K trial support a potential clinical benefit of Opdivo for the adjuvant treatment of patients with stage IIB/C melanoma, across all biomarker sub-groups. (ASCO) (Free ASCO Whitepaper)
Three-year data from the Phase 3 CheckMate -649 trial evaluating Opdivo plus chemotherapy continue to demonstrate durable long-term survival and HRQOL benefits in patients with advanced or metastatic gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma. (ASCO) (Free ASCO Whitepaper)
Two-year data from the Phase 2/3 RELATIVITY-047 trial showed consistent benefit with the company’s third distinct checkpoint inhibitor Opdualag (nivolumab and relatlimab-rmbw) in patients with previously untreated metastatic or unresectable melanoma. (ASCO) (Free ASCO Whitepaper)
Please see below for Important Safety Information and full Prescribing Information for Reblozyl, Opdualag, Opdivo, and Opdivo+Yervoy.

Please see below for Important Safety Information and full Prescribing Information, including Boxed Warnings, for Abecma, Breyanzi and Inrebic.

Investor Event

Bristol Myers Squibb will host a virtual Investor Event on Tuesday, June 6, 2023, from 7:00-8:00 a.m. CT/8:00-9:00 a.m. ET to discuss data presented at ASCO (Free ASCO Whitepaper). Company executives will provide an overview of data presented and address questions from investors and analysts.

Investors and the general public are invited to listen to a live webcast of the event at View Source An archived edition of the session will be available later that day.

Summary of Presentations

Select Bristol Myers Squibb studies at the 2023 ASCO (Free ASCO Whitepaper) Annual Meeting include:

Abstract Title

Author

Presentation
Type/#

Session Title

Session
Date/Time
(EDT)

Acute Myeloid Leukemia

Implications for acute myeloid leukemia (AML) treatment and care during the COVID-19 pandemic: A Connect Myeloid Registry study.

Bart L. Scott

Poster

Abstract #7021

Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Gastrointestinal

First-line (1L) nivolumab (NIVO) + ipilimumab (IPI) in patients (pts) with microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC): 64-month (mo) follow-up from CheckMate 142.

Heinz-Josef Lenz

Poster

Abstract #3550

Gastrointestinal Cancer—Colorectal and Anal

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Predictive value of tumor-infiltrating lymphocyte (TIL) dynamics in the tumor microenvironment (TME) during preoperative chemoradiotherapy (CRT) on pathologic complete response (pCR) in microsatellite-stable (MSS) locally advanced rectal cancer (LARC).

Mitsuho Imai

Poster

Abstract #3608

Gastrointestinal Cancer—Colorectal and Anal

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Nivolumab (NIVO) plus chemotherapy (chemo) vs chemo as first-line (1L) treatment for advanced gastric cancer/gastroesophageal junction cancer/esophageal adenocarcinoma (GC/GEJC/EAC): 3-year follow-up from CheckMate 649.

Yelena Y. Janjigian

Poster

Abstract #4025

Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Health-related quality of life (HRQOL) in patients (pts) with advanced gastric cancer/gastroesophageal junction cancer (GC/GEJC) or esophageal adenocarcinoma (EAC): 36-month results of nivolumab plus chemotherapy (N+C) versus (C) from CheckMate 649.

Elena Elimova

Poster

Abstract #4038

Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Genitourinary

Health-related quality of life (HRQoL) of risk-based patient subgroups with advanced renal cell cancer (aRCC) treated with nivolumab plus cabozantinib (NIVO+CABO) vs sunitinib (SUN) in the CheckMate 9ER trial.

David Cella

Poster

Abstract #4527

Genitourinary Cancer—Kidney and Bladder

Saturday,
June 3, 2023

9:00 AM –
12:00 PM

Adjuvant nivolumab plus ipilimumab vs placebo for patients with localized renal cell carcinoma at high risk of relapse after nephrectomy: Subgroup analyses from the phase 3 CheckMate 914 (part A) trial.

Robert J. Motzer

Oral

Abstract #4506

Genitourinary Cancer—Kidney and Bladder

Monday,
June 5, 2023

12:30 PM –
3:30PM

Gynecologic

Preliminary antitumor activity of the combination of COM701 + BMS-986207 + nivolumab in patients with recurrent, metastatic MSS endometrial cancer.

Drew W. Rasco

Poster

Abstract #5595

Gynecologic Cancer

Monday,
June 5, 2023

2:15 PM –
5:15 PM

Efficacy and final safety analysis of pre- and co-administration of nivolumab (Nivo) with concurrent chemoradiation (CCRT) followed by Nivo maintenance therapy in patients (pts) with locally advanced cervical carcinoma (LACvCa): Results from the phase I trial, GOTIC-018.

Kazuto Nakamura

Poster

Abstract #5519

Gynecologic Cancer

Monday,
June 5, 2023

5:30 PM –
7:00 PM

Preclinical testing of farletuzumab ecteribulin (FZEC [MORAb-202]) and MORAb-109, folate receptor α and mesothelin targeting antibody-drug conjugates (ADCs), in rare gynecologic cancers.

Cassandra Vandenberg

Publication Only

Abstract #e17634

Gynecologic Cancer

N/A

Head & Neck

A phase 2, open-label, multicenter study investigating efficacy and safety of RP3 oncolytic immunotherapy combined with other therapies in patients with locoregionally advanced or recurrent squamous cell carcinoma of the head and neck.

Kevin Joseph Harrington

Poster

Abstract #TPS6106

Head and Neck Cancer

Monday,
June 5, 2023

2:15 PM –
5:15 PM

Lymphoma

Longitudinal, prospective cardiovascular and metabolic risk in treatment-naive patients with chronic myeloid leukemia in chronic phase (CML-CP) starting tyrosine kinase inhibitor (TKI) therapy in a real-world setting.

Javid J. Moslehi

Poster

Abstract #7053

Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Subgroup analyses of primary refractory (refr) vs early relapsed (rel) large B-cell lymphoma (LBCL) from the TRANSFORM study of lisocabtagene maraleucel (liso-cel) vs standard of care (SOC) as second-line (2L) therapy.

Loretta J. Nastoupil

Poster

Abstract #7526

Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Response-adapted therapy (tx) with nivolumab plus brentuximab vedotin (nivo + BV) without autologous hematopoietic cell transplantation (auto-HCT) in children, adolescents, and young adults (CAYA) with low-risk relapsed/refractory (R/R) classic Hodgkin lymphoma (cHL): CheckMate 744.

Paul David Harker-Murray

Poster

Abstract #7515

Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Monday,
June 5, 2023

2:15 PM –
3:45 PM

Lisocabtagene maraleucel (liso-cel) in R/R chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Primary analysis of TRANSCEND CLL 004.

Tanya Siddiqi

Oral

Abstract #7501

Hematologic Malignancies—Lymphoma and Chronic Lymphocytic Leukemia

Tuesday,
June 6, 2023

10:45 AM –
1:45 PM

Melanoma

The validity of a machine learning algorithm in predicting response to immune checkpoint inhibitors in melanoma.

Faisal Fa’ak

Poster

Abstract #9523

Melanoma/Skin Cancers

Saturday,
June 3, 2023

2:15 PM –
5:15 PM

Preliminary safety and efficacy results from an open-label, multicenter, phase 1 study of RP2 as a single agent and in combination with nivolumab in a cohort of patients with uveal melanoma.

Joseph J. Sacco

Poster

Abstract #9527

Melanoma/Skin Cancers

Saturday,
June 3, 2023

2:15 PM –
5:15 PM

Durable clinical outcomes in patients (pts) with advanced melanoma and progression-free survival (PFS) ≥3y on nivolumab (NIVO) ± ipilimumab (IPI) or IPI in CheckMate 067.

F. Hodi

Poster

Abstract #9542

Melanoma/Skin Cancers

Saturday,
June 3, 2023

2:15 PM –
5:15 PM

Efficacy and safety of first-line (1L) nivolumab plus relatlimab (NIVO + RELA) versus NIVO plus ipilimumab (NIVO + IPI) in advanced melanoma: An indirect treatment comparison (ITC) using patient-level data (PLD).

Dirk Schadendorf

Poster

Abstract #9552

Melanoma/Skin Cancers

Saturday,
June 3, 2023

2:15 PM –
5:15 PM

Association of circulating tumor DNA kinetics with disease recurrence in patients with stage IIB/C/IV melanoma treated with adjuvant immunotherapy in CheckMate 238.

Mahrukh M. Syeda

Poster

Abstract #9577

Melanoma/Skin Cancers

Saturday,
June 3, 2023

2:15 PM –
5:15 PM

Nivolumab (NIVO) plus relatlimab (RELA) vs NIVO in previously untreated metastatic or unresectable melanoma: 2-year results from RELATIVITY-047.

Hussein A. Tawbi

Oral

Abstract #9502

Melanoma/Skin Cancers

Monday,
June 5, 2023

4:00 PM –
7:00 PM

Association of biomarkers (BMs) with efficacy of adjuvant nivolumab (NIVO) vs placebo (PBO) in patients with resected stage IIB/C melanoma (CA209 -76K).

Georgina V. Long

Oral

Abstract #9504

Melanoma/Skin Cancers

Monday,
June 5, 2023

4:00 PM –
7:00 PM

Merkel Cell Carcinoma

Non-comparative, open-label, international, multicenter phase I/II study of nivolumab (NIVO) ± ipilimumab (IPI) in patients (pts) with recurrent/metastatic Merkel cell carcinoma (MCC) (CheckMate 358).

Shailender Bhatia

Oral

Abstract #9506

Melanoma/Skin Cancers

Monday,
June 5, 2023

4:00 PM –
7:00 PM

Multiple Myeloma

Baseline and early post-infusion biomarkers associated with optimal response to idecabtagene vicleucel (ide-cel) in the KarMMa-3 study of triple-class–exposed (TCE) relapsed and refractory multiple myeloma (RRMM).

Julia Piasecki

Poster

Abstract #8031

Hematologic Malignancies—Plasma Cell Dyscrasia

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Health related quality of life (HRQoL) in patients with triple-class-exposed relapsed/refractory multiple myeloma (TCE RRMM) treated with idecabtagene vicleucel (ide-cel) versus standard regimens: Patient-reported outcomes (PROs) from KarMMa-3 phase 3 randomized controlled trial (RCT).

Michel Delforge

Poster

Abstract #8032

Hematologic Malignancies—Plasma Cell Dyscrasia

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Tumor-intrinsic features associated with progression-free survival (PFS) in patients (pts) with relapsed and refractory multiple myeloma (RRMM) treated with idecabtagene vicleucel (ide-cel).

Nicholas Strong

Poster

Abstract #8035

Hematologic Malignancies—Plasma Cell Dyscrasia

Monday,
June 5, 2023

9:00 AM –
12:00 PM

EXCALIBER-RRMM: A phase 3, two-stage study of iberdomide, daratumumab, and dexamethasone (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in patients (pts) with relapsed/refractory multiple myeloma (RRMM).

Sagar Lonial

Poster

Abstract #TPS8069

Hematologic Malignancies—Plasma Cell Dyscrasia

Monday,
June 5, 2023

9:00 AM –
12:00 PM

A phase 3, two-stage, randomized study of mezigdomide, carfilzomib, and dexamethasone (MeziKd) versus carfilzomib and dexamethasone (Kd) in relapsed/refractory multiple myeloma (RRMM): SUCCESSOR-2.

Paul G. Richardson

Poster

Abstract #TPS8070

Hematologic Malignancies—Plasma Cell Dyscrasia

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Myelodysplastic Syndrome

Efficacy and safety results from the COMMANDS trial: A phase 3 study evaluating luspatercept vs epoetin alfa in erythropoiesis-stimulating agent (ESA)-‑naive transfusion-dependent (TD) patients (pts) with lower-‑risk myelodysplastic syndromes (LR-MDS).

Guillermo Garcia-Manero

Oral

Abstract #7003

Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Friday,
June 2, 2023

2:00 PM –
5:00 PM

Hematologic and transfusion outcomes in patients (pts) with lower-risk myelodysplastic syndromes (LR-MDS) receiving luspatercept: Real-world assessment in the community practice setting.

Sudipto Mukherjee

Poster

Abstract #7057

Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Clinical outcomes by SF3B1 mutation status in patients (pts) with lower-risk myelodysplastic syndrome (LR-MDS) retreated with erythropoiesis-stimulating agents (ESAs).

Adeola Y. Makinde

Poster

Abstract #7071

Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Monday,
June 5, 2023

9:00 AM –
12:00 PM

A phase 2/3 trial of oral azacitidine (Oral-AZA) in patients (pts) with low- or intermediate-risk myelodysplastic syndromes (MDS).

Guillermo Garcia-Manero

Poster

Abstract #TPS7083

Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Monday,
June 5, 2023

9:00 AM –
12:00 PM

Myelofibrosis

Safety and efficacy of luspatercept for the treatment of anemia in patients with myelofibrosis: Results from the ACE-536-MF-001 study.

Aaron Thomas Gerds

Poster

Abstract #7016

Hematologic Malignancies—Leukemia, Myelodysplastic Syndromes, and Allotransplant

Monday,
June 5, 2023

12:30 PM –
2:00 PM

Thoracic

Phase 2 small cell lung cancer (SCLC) cohort of a phase 1b/2 trial of a liposomal formulation of eribulin in combination with nivolumab.

Koichi Azuma

Poster

Abstract #8593

Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers

Sunday,
June 4, 2023

9:00 AM –
12:00 PM

Clinical outcomes with neoadjuvant nivolumab (N) + chemotherapy (C) vs C by definitive surgery in patients (pts) with resectable NSCLC: 3-y results from the phase 3 CheckMate 816 trial.

Jonathan Spicer

Poster

Abstract #8521

Lung Cancer—Non-Small Cell Local-Regional/Small Cell/Other Thoracic Cancers

Sunday,
June 4, 2023

12:30 PM –
2:00 PM

Intracranial and systemic efficacy of repotrectinib in advanced ROS1 fusion-positive (ROS1+) non-small cell lung cancer (NSCLC) and central nervous system metastases (CNS mets) in the phase 1/2 TRIDENT-1.

Jessica Jiyeong Lin

Poster

Abstract #9017

Lung Cancer—Non-Small Cell Metastatic

Sunday,
June 4, 2023

5:30 PM –
7:00 PM

First-line (1L) nivolumab (N) + ipilimumab (I) + chemotherapy (C) vs C alone in patients (pts) with metastatic NSCLC (mNSCLC) from CheckMate 9LA: 4‑y clinical update and outcomes by tumor histologic subtype (THS).

David Paul Carbone

Poster

Abstract #LBA9023

Lung Cancer—Non-Small Cell Metastatic

Sunday,
June 4, 2023

5:30 PM –
7:00 PM

All abstracts except late-breaking abstracts will be available on the ASCO (Free ASCO Whitepaper) website at 5:00 PM EDT on Thursday, May 25. All late-breaking abstracts will be available on the ASCO (Free ASCO Whitepaper) website at 8:00 AM EDT on the day of the scientific session for the abstract presentation.

Select Bristol Myers Squibb studies at the 2023 EHA (Free EHA Whitepaper) Congress include:

Abstract Title

Author

Presentation
Type/#

Session
Date/ Time
(EDT)

Acute Myeloid Leukemia

Longitudinal characterization of molecular variants at remission and relapse: subanalyisis of the QUAZAR AML-001 trial.

Andrew Wei

Poster

Abstract #P411

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Disease monitoring of NPM1-mutant (mut) acute myeloid leukemia (AML) using measurable residual disease (MRD) assessments during oral azacitidine (oral-AZA) treatment (tx): a QUAZAR AML-001 subanalysis.

Gail Roboz

Poster

Abstract #P459

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

A real-world evaluation of treatment patterns and outcomes of acute myeloid leukemia induction therapies in the community setting.

Keri Maher

Poster

Abstract #P515

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Phase 1b OMNIVERSE trial: Safety and tolerability of oral azacitidine in combination with venetoclax for treatment of acute myeloid leukemia.

Shaun Fleming

Poster

Abstract #P567

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Real-world characteristics and use of antiemetic therapies among patients with acute myeloid leukemia treated with oral azacitidine maintenance therapy.

Ying Qui

Poster

Abstract #P587

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Implications of registry data for acute myeloid leukemia (AML) treatment and care during the COVID-19 pandemic.

John Kelly

Poster

Abstract #P589

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Beta Thalassemia

Effect of luspatercept on bone mineral density in patients with beta-thalassemia enrolled in the phase 3 BELIEVE trial.

Thomas D. Coates

Poster

Abstract #P1466

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Long-term erythroid response data from patients (pts) with non-transfusion-dependent beta-thalassemia (NTDT) receiving luspatercept in the BEYOND trial.

Ali T. Taher

Oral

Abstract #S273

Sunday, June 11, 2023

5:30 – 6:45 AM (11:30 AM

– 12:45 PM CEST)

Alpha Thalassemia

Trial in Progress: A phase 2, double-blind, randomized, placebo-controlled, multicenter study to evaluate the efficacy and safety of luspatercept to treat anemia in adults with alpha-thalassemia.

Vip Viprakasit

Abstract only publication

Abstract #PB2535

N/A

Lymphoma

Economic burden in chronic lymphocytic leukemia (CLL) for patients with ≥2 prior lines of therapy including a bruton tyrosine kinase inhibitor (BTKi) and/or B-cell lymphoma 2 inhibitor (BCL2i).

Farrukh Awan

Poster

Abstract #P1696

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Qualitative interviews to describe burden in patients (pt) with third-line or later CLL/SLL with prior exposure to bruton tyrosine kinase inhibitor (BTKi) and/or B-cell lymphoma 2 inhibitor (BCL2i).

Mona L Martin

Abstract only publication

Abstract #PB2696

N/A

Multiple Myeloma

Synergistic antitumor activity of the BCMA 2+1 T cell engager (TCE) alnuctamab (ALNUC; BMS-986349; CC-93269) and CELMoD agents in multiple myeloma (MM) preclinical models.

Bruno Paiva

Poster

Abstract #P799

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Baseline and early post-infusion biomarkers associated with optimal response to idecabtagene vicleucel (ide-cel) in the KarMMa-3 study of triple-class-exposed relapsed and refractory multiple myeloma.

Marc S. Raab

Poster

Abstract #P801

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Baseline characteristics identifying patients with multiple myeloma treated with idecabtagene vicleucel (ide-cel; BB2121) who are at risk for severe/refractory inflammatory adverse events.

Yi Lin

Poster

Abstract #P809

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Soluble factors correlated with cytokine release syndrome (CRS) with IV vs subcutaneous (SC) alnuctamab (ALNUC; BMS-986349; CC-93269) in patients with relapsed/refractory multiple myeloma (RRMM).

Luciano Costa

Poster

Abstract #P825

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Idecabtagene vicleucel (ide-cel) vs standard regimens in patients with triple-class-exposed (TCE) relapsed and refractory multiple myeloma (RRMM): KarMMa-3 subgroup analysis by prior lines of therapy.
Saloman Manier

Poster

Abstract #P866

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Mezigdomide (MEZI) plus dexamethasone (DEX) in patients (pts) with relapsed/refractory multiple myeloma (RRMM): results from the dose-expansion phase of the CC-92480-MM-001 trial.

Nizar J. Bahlis

Poster

Abstract #P868

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Idecabtagene vicleucel (ide-cel) in patients with an inadequate response to frontline autologous stem cell transplantation (ASCT): results from KarMMa-2 cohort 2c.

Melissa Alsina

Poster

Abstract #P871

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Pomalidomide, daratumumab, and dexamethasone after lenalidomide treatment in patients with relapsed or refractory multiple myeloma (RRMM): final overall survival analysis of the phase 2 MM-014 study.

Nizar J. Bahlis

Poster

Abstract #P882

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Alnuctamab (ALNUC; BMS-986349; CC-93269), a BCMA × CD3 T-cell engager, in patients (pts) with relapsed/refractory multiple myeloma (RRMM): latest results from a phase 1 first-in-human clinical study.

Sandy W. Wong

Poster

Abstract #P883

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Patient reported outcomes in triple class exposed, relapsed/refractory multiple myeloma (TCE RRMM) patients in KarMMa-3 trial (phase 3 RCT): idecabtagene vicleucel (ide-cel) versus standard regimens.

Michel Delforge

Poster

Abstract #P905

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Treatment patterns and clinical outcomes of patients with multiple myeloma previously treated with lenalidomide and an anti-CD38 monoclonal antibody: findings from the Connect MM disease registry.

Rafat Abonour

Poster

Abstract #P915

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Real-world clinical outcomes among triple-class exposed relapsed refractory multiple myeloma patients in US and Europe: PREAMBLE registry study.

Hartmut Goldschmidt

Poster

Abstract #P945

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

BMS-986393 (CC-95266), a G protein–coupled receptor class C group five member D (GPRC5D)–targeted CAR T-cell therapy for relapsed/refractory multiple myeloma (RRMM): Results from a phase 1 study.

Susan Bal

Oral

Abstract #S193

Saturday, June 10, 2023

5:30

– 6:45 AM (11:30 AM

– 12:45 PM CEST)

Idecabtagene vicleucel (ide-cel) vs standard regimens in patients with triple-class–exposed (tce) relapsed and refractory multiple myeloma (rrmm): a KarMMa-3 analysis in high-risk subgroups.

Krina Patel

Oral

Abstract #S195

Saturday, June 10, 2023

10:30

– 11:45 AM (4:30

– 5:45 PM CEST)

Elotuzumab or daratumumab in combination with pomalidomide and dexamethasone (EPd and DPd) in relapsed refractory multiple myeloma (RRMM): a network meta-analysis.

Adriana Cury

Abstract only publication

Abstract #PB2095

N/A

Myelodysplastic Syndromes

Luspatercept versus epoetin alfa for treatment (TX) of anemia in ESA-naïve patients with lower-risk myelodysplastic syndromes(LR-MDS) patients (PTS) requiring RBC transfusions: data from the COMMANDS study.

Matteo Giovanni Della Porta

Oral plenary and special session

Abstract #S102

Saturday, June 10, 2023

8:45

– 10:15 AM (2:45

– 4:15 PM CEST)

Luspatercept restores effective erythropoiesis and provides superior and sustained benefit vs epoetin alfa: biomarker analysis from the phase 3 COMMANDS study.

Uwe Platzbecker

Poster

Abstract #P693

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Distinct splicing alternations associated with clinical response to luspatercept in patients with lower-risk myelodysplastic syndromes from the MEDALIST study.

Amit Verma

Poster

Abstract #P697

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Treatment patterns and outcomes among patients with lower-risk myelodysplastic syndromes receiving luspatercept in routine clinical practice in the United States.

Sudipto Mukherjee

Poster

Abstract #P733

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

First-line treatment patterns and outcomes among patients with the newly diagnosed myelodysplastic syndromes: a global, retrospective observational cohort study.

Amer M. Zeidan

Abstract only publication

Abstract #PB2010

N/A

Myelofibrosis

Efficacy and safety of luspatercept for the treatment of anemia in patients with myelofibrosis: results from the ACE-536-MF-001 Study.

Francesco Passamonti

Oral

Abstract #S167

Friday, June 9, 2023

8:45

– 10:00 AM (2:45

– 4:00 PM CEST)

Fedratinib is effective in ruxolitinib-resistant cells: clinical and preclinical correlations.

Vikas Gupta

Poster

Abstract #P997

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

Real-world treatment patterns and healthcare resource utilization in myelofibrosis patients with anemia.

John Mascarenhas

Poster

Abstract #P1059

Friday, June 9, 2023

12:00

– 1:00 PM (6:00

– 7:00 PM CEST)

BMS-986158, a potent BET inhibitor, as monotherapy and in combination with ruxolitinib or fedratinib in intermediate- or high-risk myelofibrosis (MF): results from a phase 1/2 study.

Haifa Kathrin Al-Ali

Oral

Abstract #S213

Saturday, June 10, 2023

5:30 – 6:45 AM (11:30 AM – 12:45 PM CEST)
All EHA (Free EHA Whitepaper) abstracts except late-breaking abstracts will be available on May 11. All late-breaking abstracts will be available on June 1.

Select Bristol Myers Squibb studies at the 2023 ICML Annual Meeting include:

Abstract Title

Author

Presentation
Type/#

Session Title

Session
Date/ Time
(EDT)

Non-Hodgkin Lymphoma

CC-99282 plus R-CHOP in patients (pts) with previously untreated aggressive B-cell lymphoma (aBCL): early safety and efficacy results from a phase 1b study.

Javier Munoz

Poster

Abstract #438

Phase I-II

Wednesday, June 14, 2023

6:00AM

– 12:00 PM (12:00

– 6:00 PM CEST)

Thursday, June 15 – Friday, June 16, 2023

4:00 AM

– 12:00 PM

(10:00 AM

– 6:00 PM CEST)

Open-label phase 1/2 study of CC-99282, a cereblon E3 ligase modulator (CELMoD) agent ± rituximab,

in patients with relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL).

Jean-Marie Michot

Oral

Abstract #90

Session 14 Novel Agents

Saturday, June 17, 2023

2:45

– 4:15 AM (9:45

– 10:15 AM CEST)

Chronic Lymphocytic Leukemia

Health-related quality of life in patients with relapsed or refractory chronic lymphocytic leukemia or small lymphocytic lymphoma treated with liso-cel in TRANSCEND CLL 004.

S.S. Kenderian

Poster

Abstract #400

CAR-T (Cellular Therapies)

Wednesday, June 14, 2023

6:00AM

– 12:00 PM (12:00

– 6:00 PM CEST)

Thursday, June 15

– Friday, June 16, 2023

4:00 AM – 12:00 PM

(10:00 AM ‒ 6:00 PM CEST)

Lisocabtagene maraleucel (liso-cel) in R/R chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): primary analysis of TRANSCEND CLL 004.

Tanya Siddiqi

Oral

Abstract #26

Session 4 CLL and Richter Syndrome

Thursday, June 15, 2023

7:45

– 9:15 AM (1:45

– 3:15 PM CEST)

Large B Cell Lymphoma

Comparison of overall survival of lisocabtagene maraleucel (liso-cel) versus standard of care (SOC) adjusting for crossover in second-line (2L) R/R large B-cell lymphoma.

Franck Morschhauser

Poster

Abstract #332

DLBCL

Wednesday, June 14, 2023

6:00AM

– 12:00 PM (12:00

– 6:00 PM CEST)

Thursday, June 15

– Friday, June 16, 2023

4:00 AM

– 12:00 PM

(10:00 AM

– 6:00 PM CEST)

Lisocabtagene maraleucel (liso-cel) vs standard of care (SOC) as second-line therapy in large B-cell lymphoma (TRANSFORM study): Subgroup analyses by prior therapy response.

Loretta J. Nastoupil

Oral

Abstract #138

Session 8

"Focus on…"

Large B-Cell and Double Hit Lymphomas

Thursday, June 15

11:00 AM – 12:00 PM (5:00 ‒ 6:00 PM CEST)

All ICML accepted abstracts (except encore abstracts) will be available on June 9.