On November 19, 2018 Cancer Prevention Pharmaceuticals, Inc. (CPP), a private biotech company developing novel therapeutics to prevent cancer and other diseases, reported that CPP has been invited to give a company presentation at the 30th annual Piper Jaffray Healthcare Conference on November 28th at 9:10 am at the Palace Lotte Hotel in New York City (Press release, Cancer Prevention Pharmaceuticals, NOV 19, 2018, View Source [SID1234531443]). CPP Chairman and CEO Jeff Jacob will brief investors on the company’s clinical progress.
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CPP’s lead drug CPP-1X/sul for adults with familial adenomatous polyposis (FAP) is currently in a Phase 3 clinical trial. The FAP-310 clinical trial is a randomized, double-blind, Phase 3 trial designed to determine if the combination of eflornithine plus sulindac is superior to sulindac or eflornithine as single agents in delaying time to the first occurrence of any FAP-related event. Final data is expected in the first quarter of 2019. For more information on the clinical trial (CPP FAP-310), please visit: View Source
FAP is a rare genetic disease that if left untreated progresses to colorectal cancer in nearly 100% of patients. Currently there is no effective treatment for FAP. In 2017 the FDA granted "fast-track" status for CPP-1X/sul and previously also granted CPP-1X/sul orphan drug status.
In August 2018, Mallinckrodt Pharmaceuticals signed a license and collaboration agreement through the Mallinckrodt Plc Sucampo AG subsidiary to commercialize CPP-1X/sul combination product, if approved, in North America. This included a $5 million license fee and CPP is also eligible to receive up to an aggregate of $185 million, dependent upon achievement of other clinical development and sales milestones, subject to a reduction of up to $15 million related to amounts provided by Mallinckrodt in advance of entering into this agreement.