On September 14, 2020 Cardiff Oncology, Inc. (Nasdaq: CRDF), a clinical-stage oncology therapeutics company developing drugs to treat cancers with the greatest medical need for new treatment options, including KRAS-mutated colorectal cancer, castration-resistant prostate cancer and leukemia, reported the publication of an abstract for an electronic poster to be presented as part of the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper) Virtual Congress 2020 (Press release, Cardiff Oncology, SEP 14, 2020, View Source [SID1234565079]). The abstract highlights preliminary clinical data from the Company’s ongoing Phase 1b/2 trial evaluating onvansertib in combination with FOLFIRI and bevacizumab for the second line treatment of patients with KRAS-mutated metastatic colorectal cancer.
The preliminary data published in the abstract continue to show the safety and efficacy of onvansertib, as well as the durability of response, in combination with FOLFIRI and bevacizumab in KRAS-mutated metastatic colorectal cancer patients on their second line of therapy. The data also show that changes in plasma KRAS mutation levels during the first cycle of treatment are predictive of clinical response.
Updated results from the ongoing Phase 1b/2 trial will be presented as part of the abstract’s corresponding electronic poster. Details on the poster presentation are shown below:
Abstract ID: 2969
Presentation number: 436P
Title: Phase 1b/2 Study of the Polo-like kinase 1 (PLK1) Inhibitor, Onvansertib, in Combination with FOLFIRI and Bevacizumab for Second Line Treatment of KRAS-Mutated Metastatic Colorectal Cancer
Session Name: Poster Display Session
Presentation Date: September 17, 2020
The electronic poster will be available on the "Scientific Presentations" section of the Cardiff Oncology website at View Source
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
About the Phase 1b/2 Trial of Onvansertib in Metastatic KRAS-mutated Colorectal Cancer
Cardiff Oncology’s ongoing clinical trial is a multi-center, single-arm Phase 1b/2 study assessing the safety and preliminary efficacy of onvansertib in combination with FOLFIRI and bevacizumab in second line treatment of patients with KRAS-mutated metastatic colorectal cancer (mCRC). Trial participants are treated with onvansertib on Days 1-5, and FOLFIRI and bevacizumab on Day 1, of 14-day cycles. Primary outcome measures include safety and tolerability assessments. Secondary outcome measures include preliminary efficacy determined by radiographic scans every 8 weeks and reduction in KRAS mutant allelic burden evaluated by liquid biopsy. The trial is being conducted at the USC Norris Comprehensive Cancer Center and the three Mayo Clinic Cancer Centers. For more information on the trial, please visit View Source