On May 25, 2023 CatalYm reported that the first results from its ongoing Phase 2a trial "GDFATHER-2" (GDF-15 Antibody-mediaTed Human Effector Cell Relocation Phase 2) will be featured in an oral presentation at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting 2023 in Chicago (Press release, Catalym, MAY 25, 2023, View Source [SID1234632052]). The trial is evaluating CatalYm’s lead GDF-15 neutralizing antibody visugromab in combination with immune checkpoint inhibitor nivolumab in last-line, anti-PD-1/PD-L1 relapsed/refractory patients. Growth and differentiation factor 15 (GDF-15) is recognized as a negative regulator of antitumoral T cell activity preventing T cell recruitment to the tumor microenvironment as well as potently suppressing an adaptive immune response by additional mechanisms recently identified. The ASCO (Free ASCO Whitepaper) Annual Meeting will be held in Chicago, Illinois, from June 2 to 6, 2023.
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Oral presentation details:
Presentation Title: Initial results from the phase 2a trial of visugromab (CTL-002) + nivolumab in advanced/metastatic anti-PD1/-L1 relapsed/refractory solid tumors (The GDFATHER-TRIAL)
Presenter: Dr. Ignacio Melero Bermejo, MD | Clinica Universidad de Navarra
Session: Developmental Therapeutics-Immunotherapy
Session Date and Time: Sunday, June 4, 2023, from 9:45 AM – 12:45 PM CDT
Location: In-Person | Arie Crown Theater | McCormick Place | Live Stream
Presentation Number: 2501
The full abstract details can be accessed via View Source The company will provide further information and a summary of the data following the oral presentation at ASCO (Free ASCO Whitepaper).