On February 23, 2026 Bristol Myers Squibb (NYSE: BMY) reported that the company will participate in the TD Cowen 46th Annual Health Care Conference on Monday, March 2, 2026.

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The company will take part in a fireside chat beginning at 9:50 a.m. ET.

Investors and the general public are invited to listen to the session by visiting View Source An archived edition of the session will be available following its conclusion.

(Press release, Bristol-Myers Squibb, FEB 23, 2026, View Source [SID1234662845])

On February 23, 2026 Sana Biotechnology, Inc. (NASDAQ: SANA), a company focused on changing the possible for patients through engineered cells, reported that it will webcast its presentations at two investor conferences in March. The presentations will feature a business overview and update.

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Sana will present at the Cowen 46th Annual Health Care Conference at 1:10 p.m. ET on Monday, March 2, 2026.
Sana will present at the Citizens Life Sciences Conference at 1:40 p.m. ET on Wednesday, March 11, 2026.

The webcasts will be accessible on the Investor Relations page of Sana’s website at View Source A replay of each presentation will be available at the same location for 30 days following the conference.

(Press release, Sana Biotechnology, FEB 23, 2026, View Source [SID1234662861])

On February 23, 2026 Arcus Biosciences, Inc. (NYSE:RCUS), a clinical-stage, global biopharmaceutical company focused on developing differentiated molecules for patients with cancer and inflammatory and autoimmune diseases, reported a new analysis of efficacy and biomarker data for casdatifan, a HIF-2a inhibitor with best-in-class potential, in late-line metastatic clear cell renal cell carcinoma (ccRCC) from the Phase 1/1b ARC-20 study. These data will be presented in a poster session on February 28, 2026, at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Genitourinary Cancer Symposium.

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"Patients in the 100mg tablet cohort reached 15.1 months of PFS, and 45% had a confirmed response when treated with the same dose and formulation being used in the ongoing Phase 3 study," said Richard Markus, M.D., Ph.D., chief medical officer at Arcus Biosciences. "With longer follow-up, ORR continued to improve for both the 100mg QD cohort and pooled analysis, increasing meaningfully since the last analysis. Whether evaluating the pooled data or 100mg Phase 3 formulation data, PFS was two or nearly three times longer relative to published data from studies with the only marketed HIF-2a inhibitor in the same patient population."

ARC-20 is a Phase 1/1b dose-escalation and expansion study that included four monotherapy cohorts (n=121), which evaluated casdatifan in patients with metastatic ccRCC, most of whom had progressed on at least two prior lines of therapy, including both an anti-PD-1 and a VEGFR tyrosine kinase inhibitor (TKI): 50mg twice daily (BID), 50mg QD, 100mg QD (tablet) and 150mg QD. For biomarker analysis, serial serum samples were collected, and associations between maximal sEPO reduction and response to casdatifan were evaluated. These data showed that the magnitude and durability of EPO suppression correlated with clinical benefit, thereby linking pharmacodynamic modulation by casdatifan to clinical efficacy, including ORR and PFS.

"An analysis of data for casdatifan, a next-generation HIF-2a inhibitor, showed the majority of patients reached near-maximal sEPO reduction, and that deep and prolonged suppression was associated with better response and clinical benefit," said Toni K. Choueiri, M.D., director of the Lank Center for Genitourinary (GU) Oncology at Dana-Farber, the Jerome and Nancy Kohlberg chair and professor of medicine at Harvard Medical School, and lead investigator of ARC-20. "HIF-2a inhibition has emerged as a novel treatment that is changing the treatment paradigm for patients with ccRCC, and the results from ARC-20 are very encouraging. I look forward to working with Arcus to bring this medicine to ccRCC patients as soon as possible."

At the time of data cut-off (DCO, August 15, 2025), no unexpected safety signals were observed, and casdatifan had an acceptable and manageable safety profile across all doses. Across all four cohorts, no patients discontinued treatment due to anemia, and four patients (3%) discontinued due to hypoxia.

100mg QD Tablet

(Phase 3 dose)

(n=32)

Pooled Analysis

(50mg BID, 50mg QD, 100mg QD, 150mg QD)

(n=127)

Safetya

Any Serious Treatment-Emergent Adverse Events (TEAEs)

31% (10)

31% (39)

Grade ≥3 TEAEs related to casdatifanb

Anemia

25% (8)

41% (52)

Hypoxia

9% (3)

11% (14)

TEAEs resulting in discontinuation

9% (3)

9% (11)

Anemiac

0

0

Hypoxiac

3% (1)

2% (3)

a The safety-evaluable population included all dose-expansion enrolled patients who received any amount of any study treatment.

b Grade ≥3 TEAEs related to casdatifan that occurred in more than 5% of patients in the pooled analysis.

c Prespecified events of interest.

An updated analysis was conducted for efficacy with a DCO of January 30, 2026. The safety profile remained consistent with the August 15, 2025 DCO. Key differences between the August 15, 2025 and January 30, 2026 DCO are as follows:

100mg QD tablet cohort: At 17.9 months of median follow-up, cORR increased to 45% with an mPFS of 15.1 months. An mPFS had not yet been reached, and cORR was 35% at the August 15, 2025 DCO.
Pooled analysis: At 20.8 months of median follow-up, cORR increased to 35%, with three of the four monotherapy cohorts having cORRs greater than 30%, and mPFS was stable at 12.2 months; cORR was 31% at the August 15, 2025 DCO.

100mg QD Tablet

(Phase 3 dose)

(n=31)

Pooled Analysis

(50mg BID, 50mg QD, 100mg QD, 150mg QD)

(n=121)

Efficacya

Median Follow-Up

17.9 months

20.8 months

Median PFS

15.1 months

12.2 months

[95% CI]

[5.7,NE]

[9.4,16.5]

12-month PFS [95% CI]

61% [42,76]

51% [41,60]

6-month PFS [95% CI]

68% [48,81]

63% [54,71]

Confirmed ORR (cORR) [95% CI]

45% (14) [27,64]

35% (42) [26,44]

Confirmed BOR

CR

0

1% (1)

PR

45% (14)

34% (41)

SD

39% (12)

46% (56)

PDb,c

16% (5)

19% (23)

Median Time to Response

2.6 months

2.8 months

Disease Control Rate

84% (26)

81% (98)

[95% CI]

[66,95]

[73,88]

BOR: best overall response; CI: confidence interval; CR: complete response; NE: not estimable; PR: partial response; PD: progressive disease; SD: stable disease

a As of DCO of January 30, 2026; efficacy-evaluable population for this expansion cohort is defined as all eligible participants who received any study treatment and have at least one post-baseline efficacy assessment, or discontinued study treatment due to progressive disease or death.

b PD was defined according to RECIST v1.1 as a ≥ 20% increase in the sum of diameters of target lesions relative to the smallest sum on study (including baseline, if smallest), with an absolute increase of ≥ 5 mm. The appearance of 1 or more new lesions was also considered progression.

c Includes two patients in the 100mg QD tablet cohort, and also included in the pooled analysis, who had clinical progression before the first scan and therefore did not meet criteria for progressive disease per RECIST. PD based on RECIST criteria was 10% (n=3) for the 100mg QD tablet cohort and 17% (n=121).

About Casdatifan (AB521)

Casdatifan is a small-molecule inhibitor of HIF-2a, a master switch that turns on hundreds of genes in response to low oxygen levels. In a majority of people with the most common form of kidney cancer (clear cell renal cell carcinoma), genetic anomalies result in the dysregulation of this master switch and transformation of normal kidney cells into cancerous ones.

Casdatifan was designed to provide deep and durable inhibition of the HIF-2a pathway. Early clinical studies have shown high response rates and a low primary progression rate relative to clinical benchmarks, warranting further investigation in late-stage studies. Casdatifan, which is administered in pill form once daily, has a safety profile that allows it to be investigated in combination with other treatments.

Currently, fewer than one in four patients with late-line ccRCC respond to monotherapy treatment with a HIF-2a inhibitor, and a next-generation option, like casdatifan, may help more patients achieve benefit from HIF-2a-inhibitor treatment.

Casdatifan is an investigational molecule. Approval from any regulatory authority for its use has not been received, and its safety and efficacy have not been established. Taiho has development and commercial rights in Japan and other countries in Asia, excluding China. Arcus Biosciences holds full rights to casdatifan everywhere else globally.

About RCC

According to the American Cancer Society, kidney cancer is among the top 10 most commonly diagnosed forms of cancer among both men and women in the U.S., and an estimated 80,450 Americans will be diagnosed with kidney cancer in 2026. Clear cell RCC is the most common type of kidney cancer in adults. If detected in its early stages, the five-year survival rate for kidney cancer is high; for patients with advanced or late-stage metastatic kidney cancer, however, the five-year survival rate is only 19%. For metastatic kidney cancer, targeted drug therapies are one of the main treatment options.

(Press release, Arcus Biosciences, FEB 23, 2026, View Source [SID1234662878])

On February 23, 2026 Bristol Myers Squibb (NYSE: BMY) reported positive top-line results from the ongoing, ex-US, Phase 2 registrational study (NCT05664737) evaluating Reblozyl (luspatercept-aamt) versus placebo for anemia in adults with Alpha (α)-Thalassemia.

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The non‑transfusion‑dependent (NTD) and transfusion‑dependent (TD) cohorts of the study met their respective primary endpoints, with Reblozyl demonstrating a statistically significant and clinically meaningful increase in hemoglobin levels in NTD patients with α‑thalassemia, and a statistically significant and clinically meaningful decrease in red blood cell (RBC) transfusion burden in TD patients with α‑thalassemia. The study also met all key secondary endpoints. Safety findings were consistent with the known profile of Reblozyl in thalassemia.

"These positive data further support the potential of Reblozyl for patients around the world," said Cristian Massacesi, Executive Vice President, Chief Medical Officer and Head of Development, Bristol Myers Squibb. "This is the first and only registrational Phase 2 trial specifically designed to address the needs of patients, especially in China, with alpha-Thalassemia, a lifelong disease with limited treatment options and the potential for serious long‑term complications."

The data will be presented at an upcoming medical congress and will be discussed with the Center for Drug Evaluation in China.

About the Study (NCT05664737)

The Phase 2 trial is evaluating the efficacy and safety of luspatercept plus best supportive care versus placebo for anemia in adults and adolescents with α-thalassemia, including both red blood cell (RBC) transfusion-dependent (TD) and non-transfusion-dependent (NTD) cohorts. The primary endpoint of the NTD cohort measures an increase from baseline of ≥ 1 grams (g)/deciliter (dL) in mean hemoglobin (Hb) values over the continuous 12-week interval from Week 13 to Week 24 in the absence of RBC transfusion. The primary endpoint of the TD cohort measures ≥ 50% reduction from baseline in RBC transfusion burden with a reduction of at least 2 units during any continuous 12 weeks during Week 13-48 compared to 12-week interval immediately prior to date of first dose. The adolescent NTD and TD cohorts are ongoing.

About Reblozyl

Reblozyl, a first-in-class therapeutic option, promotes late-stage red blood cell maturation in animal models. Reblozyl is being developed and commercialized through a global collaboration with Merck as of November 2021. Reblozyl is indicated in the U.S. for the treatment of:

anemia in adult patients with beta thalassemia who require regular red blood cell (RBC) transfusions, and
anemia without previous erythropoiesis stimulating agent use (ESA-naïve) in adult patients with very low- to intermediate-risk myelodysplastic syndromes (MDS) who may require regular red blood cell (RBC) transfusions.
anemia failing an erythropoiesis stimulating agent and requiring 2 or more red blood cell (RBC) units over 8 weeks in adult patients with very low- to intermediate-risk myelodysplastic syndrome with ring sideroblasts (MDS-RS) or with myelodysplastic/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T).
Reblozyl is not indicated for use as a substitute for RBC transfusions in patients who require immediate correction of anemia. In the U.S., Reblozyl is not indicated for use in patients with non-transfusion-dependent beta thalassemia.

Important Safety Information

WARNINGS AND PRECAUTIONS

Thrombosis/Thromboembolism

In adult patients with beta thalassemia, thromboembolic events (TEE) were reported in 8/223 (3.6%) of REBLOZYL-treated patients. TEEs included deep vein thrombosis, pulmonary embolus, portal vein thrombosis, and ischemic stroke. All patients with TEE were splenectomized and had at least 1 other risk factor for developing TEE, such as a history of thrombocytosis or concomitant use of hormone-replacement therapy. The occurrence of TEE was not correlated with elevated hemoglobin levels. Patients with known risk factors for thromboembolism (splenectomy or concomitant use of hormone replacement therapy) may be at further increased risk of thromboembolic conditions. Consider thromboprophylaxis in patients at increased risk of TEE. Monitor patients for signs and symptoms of thromboembolic events and institute treatment promptly.

Hypertension

Hypertension was reported in 11.4% (63/554) of REBLOZYL-treated patients. Across clinical studies, the incidence of Grade 3 to 4 hypertension ranged from 2% to 9.6%. In patients with beta thalassemia with normal baseline blood pressure, 13 (6.2%) patients developed systolic blood pressure (SBP) ≥130 mm Hg and 33 (16.6%) patients developed diastolic blood pressure (DBP) ≥80 mm Hg. In ESA-refractory or -intolerant adult patients with MDS with normal baseline blood pressure, 26 (30%) patients developed SBP ≥130 mm Hg and 23 (16%) patients developed DBP ≥80 mm Hg. In ESA-naïve adult patients with MDS with normal baseline blood pressure, 23 (36%) patients developed SBP ≥140 mm Hg and 11 (6%) patients developed DBP ≥80 mm Hg. Monitor blood pressure prior to each administration. Manage new or exacerbations of preexisting hypertension using anti-hypertensive agents.

Extramedullary Hematopoietic (EMH) Masses

In adult patients with transfusion-dependent beta thalassemia, EMH masses were observed in 3.2% of REBLOZYL-treated patients, with spinal cord compression symptoms due to EMH masses occurring in 1.9% of patients (BELIEVE and REBLOZYL long-term follow-up study).

In a study of adult patients with non-transfusion-dependent beta thalassemia, a higher incidence of EMH masses was observed in 6.3% of REBLOZYL-treated patients vs. 2% of placebo-treated patients in the double-blind phase of the study, with spinal cord compression due to EMH masses occurring in 1 patient with a prior history of EMH. REBLOZYL is not indicated for use in patients with non-transfusion-dependent beta thalassemia.

Possible risk factors for the development of EMH masses in patients with beta thalassemia include history of EMH masses, splenectomy, splenomegaly, hepatomegaly, or low baseline hemoglobin (<8.5 g/dL). Signs and symptoms may vary depending on the anatomical location. Monitor patients with beta thalassemia at initiation and during treatment for symptoms and signs or complications resulting from the EMH masses and treat according to clinical guidelines. Discontinue treatment with REBLOZYL in case of serious complications due to EMH masses. Avoid use of REBLOZYL in patients requiring treatment to control the growth of EMH masses.

Embryo-Fetal Toxicity

REBLOZYL may cause fetal harm when administered to a pregnant woman. REBLOZYL caused increased post-implantation loss, decreased litter size, and an increased incidence of skeletal variations in pregnant rat and rabbit studies. Advise pregnant women of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment and for at least 3 months after the final dose.

ADVERSE REACTIONS

Beta-Thalassemia

Serious adverse reactions occurred in 3.6% of patients on REBLOZYL. Serious adverse reactions occurring in 1% of patients included cerebrovascular accident and deep vein thrombosis. A fatal adverse reaction occurred in 1 patient treated with REBLOZYL who died due to an unconfirmed case of acute myeloid leukemia (AML).

Most common adverse reactions (at least 10% for REBLOZYL and 1% more than placebo) were headache (26% vs 24%), bone pain (20% vs 8%), arthralgia (19% vs 12%), fatigue (14% vs 13%), cough (14% vs 11%), abdominal pain (14% vs 12%), diarrhea (12% vs 10%) and dizziness (11% vs 5%).

ESA-naïve adult patients with Myelodysplastic Syndromes

Grade ≥3 (≥2%) adverse reactions included hypertension and dyspnea. The most common (≥10%) all-grade adverse reactions included diarrhea, fatigue, hypertension, peripheral edema, nausea, and dyspnea.

ESA-refractory or -intolerant adult patients with Myelodysplastic Syndromes

Grade ≥3 (≥2%) adverse reactions included fatigue, hypertension, syncope and musculoskeletal pain. A fatal adverse reaction occurred in 5 (2.1%) patients. The most common (≥10%) adverse reactions included fatigue, musculoskeletal pain, dizziness, diarrhea, nausea, hypersensitivity reactions, hypertension, headache, upper respiratory tract infection, bronchitis, and urinary tract infection.

LACTATION

It is not known whether REBLOZYL is excreted into human milk or absorbed systemically after ingestion by a nursing infant. REBLOZYL was detected in milk of lactating rats. When a drug is present in animal milk, it is likely that the drug will be present in human milk. Because many drugs are excreted in human milk, and because of the unknown effects of REBLOZYL in infants, a decision should be made whether to discontinue nursing or to discontinue treatment. Because of the potential for serious adverse reactions in the breastfed child, breastfeeding is not recommended during treatment and for 3 months after the last dose.

DRUG ABUSE POTENTIAL

Abuse: Abuse of REBLOZYL may be seen in athletes for the effects on erythropoiesis. Misuse of drugs that increase erythropoiesis, such as REBLOZYL, by healthy persons may lead to polycythemia, which may be associated with life-threatening cardiovascular complications.

Please see accompanying U.S. Full Prescribing Information for REBLOZYL.

(Press release, Bristol-Myers Squibb, FEB 23, 2026, View Source;Thalassemia/default.aspx [SID1234662846])

On February 23, 2026 Supernus Pharmaceuticals, Inc. (Nasdaq: SUPN), a biopharmaceutical company focused on developing and commercializing products for the treatment of central nervous system (CNS) diseases, reported that management will participate in the following March investor conferences:

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TD Cowen 46th Annual Health Care Conference
Date:
Fireside chat:
Place:
Webcast Link:
Monday, March 2, 2026
2:30 p.m. ET
Boston Marriott Copley Place, Boston, Mass.
Here

Jefferies Biotech on the Beach Summit
Date:
Place: Tuesday, March 10, 2026
1 Hotel South Beach, Miami Beach, Fla.

Barclays 28th Annual Global Healthcare Conference
Date:
Fireside chat:
Place:
Webcast Link: Wednesday, March 11, 2026
2:00 p.m. ET
Loews Miami Beach, Miami Beach, Fla.
Here

Investors interested in arranging a meeting with the Company’s management during these conferences should contact the respective conference coordinators.

A live audio webcast of the TD Cowen and Barclays Conference presentations can also be accessed on the Events & Presentations section of the Supernus Pharmaceuticals website at www.supernus.com. Archived replays of these webcasts will be available for 60 days on the Company’s website following the conference.

(Press release, Supernus, FEB 23, 2026, View Source [SID1234662862])