Revolution Medicines to Participate in Cowen 2nd Annual Virtual Oncology Innovation Summit

On May 18, 2021 Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage precision oncology company developing targeted therapies to inhibit frontier targets in RAS-addicted cancers, reported that the company will participate in the upcoming Cowen 2nd Annual Virtual Oncology Innovation Summit (Press release, Revolution Medicines, MAY 18, 2021, View Source [SID1234580193]). Steve Kelsey, M.D., president, research and development, will be the featured speaker in a fireside chat at the event.

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Details of the company’s participation are as follows:

Cowen 2nd Annual Virtual Oncology Innovation Summit
Conference Date: May 20-21, 2021
Fireside Chat Time/Date: 12:40 p.m. Eastern on Friday, May 21, 2021
Format: Virtual conference

[Press release] InterSystems & Oncodesign partner for the optimization of data use to enhance and accelerate Drug Discovery processes in oncology

On May 18, 2021 InterSystems, a leader in healthcare data management, and Oncodesign (Paris:ALONC), a biopharmaceutical company specializing in precision medicine, reported the signing of a strategic partnership aimed at advancing research for new treatments in the field of oncology (Press release, Oncodesign, MAY 18, 2021, View Source [SID1234580210]).

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In a context characterized by an exponential growth of data volumes over the last 20 years, the quality and use of health and research data have become two critical issues for all healthcare stakeholders. The current health crisis has only reinforced the importance of an agile and decompartmentalized strategy for health data governance.

As part of this partnership, Oncodesign has chosen to combine its proprietary platform for the identification and validation of new therapeutic targets, called OncoSNIPER, with InterSystems’ unified health data management platform, known as InterSystems IRIS for Health. This alliance will allow both companies to develop and optimize essential synergies between the two platforms.

The InterSystems IRIS for Health data platform will be integrated into Oncodesign’s recently established Artificial Intelligence (AI) Business Unit for the storage and management of various preclinical and clinical data sources, which are highly valuable to each of the businesses involved in the drug discovery process. By analyzing and better exploiting the data consolidated through InterSystems IRIS for Health, Oncodesign’s AI BU will optimize the development of OncoSNIPER, notably through more accurate functioning of its algorithms. In addition, InterSystems will provide Oncodesign with the benefit of its international network of strategic academic partners generating health data (hospitals and universities), particularly in North America.

For InterSystems, this partnership is part of a strategic approach to healthcare players through its access to Oncodesign’s solid expertise in drug discovery and reflects its historical commitment to oncology. With a solid domestic network, InterSystems has been working for many years with major cancer centers (known as CLCC in France) through its patient administrative and clinical management solution, InterSystems TrakCare (especially in Dijon, Nice and Reims), as well as with the Toulouse University Cancer Institute – Oncopole (IUCT-O) with InterSystems HealthShare, for comprehensive patient management and better coordination of the various private and public players in the region. The company has also made its expertise in health data exploitation available to innovative partners such as the start-up MyPL and the Guerbet Group.

For Michel Amous, Regional Director EMEA at InterSystems: "We are delighted to begin this partnership with Oncodesign, which has been a major player in the biotechnology industry for 25 years. Our goal is to provide them with our expertise in optimizing data platforms to build a new intelligent architecture for oncology research. The pooling of health data – scattered, heterogeneous but so valuable – is not just a simple operational consolidation. It is a project with strategic scope aimed at aggregating the various sources of data available to Oncodesign in order to improve communication between them. This dynamic governance will enable Oncodesign to remain at the forefront of biopharmaceutical innovation and ultimately to commercialize new therapeutic solutions to better serve the public interest. "

For Oncodesign, this partnership is the second step in its strategic development based around AI after the launch in 2017 of the OncoSNIPER project (clinical trial of 600 patients with 3 oncology indications and 16 partners). After generating large amounts of heterogeneous clinical data, the company needs to structure the available data using the InterSystems IRIS for Health data platform, before implementing the algorithms needed to select sub-populations of patients with treatment-resistant cancers.

Philippe Genne, Chairman and CEO of Oncodesign, stated: "We have known the InterSystems teams well for several years, and we are therefore very pleased to formalize our collaboration through this ambitious partnership. Our expertise at Oncodesign is in developing new treatments and InterSystems’ is in leveraging data to accelerate the digital transformation of companies. Together, we will be able to pool our respective fields of expertise in order to make our drug discovery process in precision medicine more reliable and even faster. Traditionally, the lead optimization phase alone can last up to 3 years and cost between 10 and 12 million euros with random results in the medium term (1/10 success rate). Today, artificial intelligence is changing the game: the exploitation of data gives us the possibility to make more informed choices in increasingly rapid timeframes. "

This collaboration will bring together several distinct and complementary fields of expertise, including data science, artificial intelligence, pharmacology, chemistry, biology and clinical research. The two companies share a common goal: to harness the power of data to develop and industrialize new therapeutic solutions in the field of oncology.

On May 21st next, Oncodesign will inaugurate its new headquarters in Dijon (Bâtiment Jean Mermoz – 18 rue Jean Mazen), which will house its AI teams. On the same day, the company will also launch its new development strategy based on AI approaches.

KDx Diagnostics, Cardiff University, Cardiff and Vale University Health Board and Cellpath announce Initiation of Accelerate project to develop a non-invasive URO17® urine test for Bladder Cancer in hematuria patients

On May 18, 2021 KDx Diagnostics, Inc. (KDx), Clinical Innovation Accelerator (CIA), Cardiff University, Cardiff and Vale University Health Board C&VUHB) and CellPath, reported a partnership to develop a non-invasive urine test for suspected bladder cancer patients through the Accelerate programme (Press release, KDx Diagnostics, MAY 18, 2021, View Source [SID1234580226]). KDx Diagnostics Inc., located in Campbell, CA, USA, has developed a non-invasive urine test, URO17 that has shown high accuracy detection of bladder cancer in multiple independent studies, and will provide all technical components for the project.

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There are over 197,000 newly diagnosed cases of bladder cancer in Europe, and 430,000 globally, with 81,000 cases in the US alone. Accurate detection of new bladder cancer is currently very difficult and expensive, requiring invasive camera-based testing methodology. KDx’s URO17 test has demonstrated 100% sensitivity and over 90% specificity in detecting new and recurrent bladder cancer in multiple studies. During the Accelerate programme, KDx will be partnering with CellPath Ltd, Newtown, UK, Cardiff University and C&VUHB to conduct a large clinical study to evaluate URO17 in the detection of new bladder cancer in patients with hematuria (blood in their urine), and to develop a home sample collection programme that will facilitate detection of bladder cancer and reduce the need for patients to come into a clinic or a hospital for testing.

"We are excited to partner with Cardiff University, Cardiff and Vale University Health Board and CellPath through the Accelerate programme to validate and provide URO17 tests in the UK. Through our initial studies, we have shown that the URO17 test exhibited extremely high sensitivity and specificity in detecting bladder cancer from urine samples in both recurrent and new cancers. The study under the Accelerate programme will examine the performance of URO17 in a real-life clinical setting in patients with hematuria, which will facilitate a wide distribution of the test throughout the UK and the rest of Europe. Furthermore, a development and launch of the URO17 home sample collection programme will provide safe and cost-effective means for detecting new bladder cancer which is critical in the age of COVID-19 and beyond." said Nam W. Kim, Ph.D., KDx’ CEO, and CTO.

Professor Howard Kynaston from Cardiff and Vale University Health Board and Cardiff University said "There is an urgent need to develop accurate non-invasive tests, such as biomarkers, in the fight against cancer. URO17 has tremendous potential to distinguish between urinary symptoms due to bladder cancer and more benign causes, speeding up rapid diagnosis and reducing need for unnecessary invasive tests."

xCures partners with CureScience to make leading translational research available to advanced cancer patients

On May 18, 2021 xCures reported its partnership with CureScienceTM so that patients across the US can have access to leading translational science approaches through a decentralized clinical research platform (Press release, xCures, MAY 18, 2021, View Source [SID1234584918]).

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The xCures platform will track outcomes and clinical endpoints to validate CureScience’s assays and research protocols, thereby leveraging CureScience’s diagnostic assays and growing precision medicine resources. This synergy will be highly beneficial for patients and doctors dealing with advanced cancer by recognizing and targeting specific patients and patient populations that may benefit from a particular test or treatment.

"xCures’ collaboration with CureScience presents a significant step towards reaching our mutual goal to help advanced cancer patients," stated Mika Newton, xCures’ CEO. "Together, we will be able to identify better treatments and treatment regimens through the use of real-world data, scalable technologies, as well as patient advocacy and empowerment."

Besides the benefits this collaboration can deliver to patients and doctors, it can also provide insight into novel assays for CureScience to develop. Results obtained will be key for pharmaceutical and biotechnology companies focused on cancer therapeutics and diagnostics and enable negotiations of broader access to investigational and approved therapies.

"One of our goals is to empower patients to make informed decisions. A collaboration with xCures on patient-facing and outcomes tracking infrastructure provides a significant value towards this goal," stated Shashaanka Ashili, CEO of CureScience. "This collaboration provides an opportunity to identify and implement joint clinical and translational opportunities that will lead towards achieving personalized precision medicine goals."

Institut Bergonié and Seven and Eight Biopharmaceuticals Inc. Announce the First Patient Treated in the AGADIR Study of BDB001 in Combination with Atezolizumab and Immunogenic Radiotherapy in Solid Tumors

On May 18, 2021 Institut Bergonié, a cancer center based in Bordeaux, and Seven and Eight Biopharmaceuticals Inc., a clinical stage biotechnology company specializing in immuno-oncology, reported the treatment of the first patient in their collaboration to study BDB001 (Press release, Seven and Eight Biopharmaceuticals, MAY 18, 2021, View Source [SID1234580211]). Institut Bergonié is the sponsor of the AGADIR Phase II protocol, "Atezolizumab combined with BDB001 and Immunogenic Radiotherapy in patients with advanced solid tumors" (NCT03915678), which will enroll patients with difficult-to-treat solid tumors across 10 clinical centers in France. The study is funded in a public-private partnership by a grant from the French National Cancer Institute (Institut National du Cancer, INCa) and the Fondation ARC (La Fondation ARC pour la recherche sur le cancer) (INCa-ARC_13579) and performed in collaboration with Roche, who will supply atezolizumab. BDB001 is a first-in-class Toll-like receptor 7/8 (TLR7/8) agonist, which is delivered intravenously, allowing for broader treatment of solid tumors compared to intratumoral TLR agonists in development.

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"We are delighted to begin this clinical study with BDB001. Our collaboration with Seven and Eight Biopharma allows us to explore a new and potentially valuable treatment option to our patients," declared Professor Antoine Italiano, Head of Early Phase Trials Unit, Institut Bergonié.

"This partnership with Institut Bergonié is a milestone in our development program for BDB001. The clinical trial expertise provided by Institut Bergonié and their collaborators will help us better understand the potential role for BDB001 as an immuno-oncology backbone in combination with checkpoint inhibitors and radiotherapy in the treatment of solid tumors," says Dr. Robert Andtbacka, Chief Medical Officer at Seven and Eight Biopharma Inc.