Tempus Announces the Acquisition of Paige

On August 22, 2025 Tempus AI, Inc. (NASDAQ: TEM), a technology company leading the adoption of AI to advance precision medicine, reported the acquisition of Paige, an AI company specializing in digital pathology (Press release, Tempus, AUG 22, 2025, View Source [SID1234655439]). The acquisition allows Tempus to grow its dataset, expand its experienced technical team, and establish a strong footprint in digital pathology with an industry leading technology portfolio.

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Founded in 2017, Paige has developed and deployed several AI applications, including the first FDA-cleared AI application in pathology, allowing researchers and pathologists to better detect cancer, which enables care teams to make more precise and informed treatment decisions. Paige has developed and refined its products through a dataset that includes almost 7 million digitized pathology slide images and associated clinical and molecular data, stripped of patient identifiers to protect privacy. Leveraging a dataset of de-identified data and images that spans 45 countries and diverse genders, races, ethnicities, and regions, Paige has also developed the first million-slide foundation model for cancer, empowering researchers and life sciences companies to better understand pathology data, and enabling the advancement of drug discovery and development.

"As we embark upon building the largest foundation model that’s ever been built in oncology, the acquisition of Paige substantially accelerates our efforts," said Eric Lefkofsky, Founder and CEO of Tempus. "Paige is a leader in digital pathology and has amassed one of the most comprehensive digital pathology datasets in the world through its relationship with Memorial Sloan Kettering Cancer Center. We believe both the Paige team, with their deep generative AI experience, and the dataset they have built, will be catalytic across all of our AI efforts."

"We’ve always believed that the future of cancer care and precision medicine lies in harnessing the full potential of AI to redefine what’s possible in digital pathology and transform how cancer is detected, understood, and treated," said Razik Yousfi, CEO and CTO of Paige. "By joining forces with Tempus, a company already making remarkable strides in oncology diagnostics, we can bring our innovations to a broader patient population and deliver even greater impact. We are confident this partnership is uniquely positioned to maximize and expand the reach of our technology, ensuring it fulfills our mission of delivering powerful, data-driven insights."

Tempus is acquiring Paige for $81.25 million, which is being paid predominantly in Tempus common stock, as well as Tempus’ assumption of Paige’s remaining commitment under its existing Microsoft Azure cloud services agreement.

Jechobio Receives NMPA IND Clearance for JLM019 for the Treatment of Advanced Malignant Tumors

On August 21, 2025 Jecho Biopharmaceuticals Co., Ltd. (hereinafter referred to as "Jechobio"), a global, clinical stage biopharmaceutical company advancing medicines focusing in oncology, reported that the National Medical Products Administration (NMPA) has delivered a Notice of Approval for Drug Clinical Trial for JLM019 injection in the treatment of advanced malignant tumors (Press release, Jecho Laboratories, AUG 21, 2025, View Source [SID1234655425]).

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"The NMPA’s clearance of our Investigational New Drug application is an important regulatory milestone for Jechobio. JLM019 represents a potential first-in-class next generation IO therapy. We look forward to the expected dosing of the first patient with JLM019 in the next few months," said Dr. Xiaodong Xiao, CEO of Jechobio.

Jechobio anticipates the enrollment of the first patient in the dose escalation portion of its clinical trial in Q4 2025.

About JLM019

JLM019 is an innovative CD80/PD-1 dual-targeted Fc fusion protein that simultaneously blocks immunosuppression and activates immunostimulation. JLM019 injection exhibits broad-spectrum anti-tumor properties and has demonstrated significant anti-tumor activity in multiple solid tumor models, offering hope for the treatment of patients with advanced cancer.

Oncopeptides publishes Q2 report 2025

On August 21, 2025 Oncopeptides reported second quarter 2025 financial results (Presentation, Oncopeptides, AUG 21, 2025, View Source [SID1234655618]).

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UroGen Pharma to Present at Upcoming Investor Conferences

On August 21, 2025 UroGen Pharma Ltd. (Nasdaq: URGN), a biotech company dedicated to developing and commercializing innovative solutions that treat urothelial and specialty cancers, reported that it will participate in the following investor conferences in September (Press release, UroGen Pharma, AUG 21, 2025, View Source [SID1234655426]).

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Wells Fargo Healthcare Conference

Date / Time: September 3rd, at 2:15 PM ET
Format: Fireside Chat
Location: Boston, MA

Cantor Fitzgerald Global Healthcare Conference

Date / Time: September 4th, at 3:55 PM ET
Format: Fireside Chat
Location: New York, NY

H.C. Wainwright 27th Annual Global Healthcare Conference

Date / Time: September 8th, at 9:00 AM ET
Format: Fireside Chat
Location: New York, NY

The conference webcasts will be available through the Events section of the Company’s Investor Relations website. Replays will be available for approximately 90 days following the event.

European Commission Approves Tablet Formulation of BeOne Medicines’ BRUKINSA® for All Approved Indications

On August 21, 2025 BeOne Medicines Ltd. (Nasdaq: ONC; HKEX: 06160; SSE: 688235), a global oncology company, reported that the European Commission has approved a new film-coated tablet formulation of BRUKINSA (zanubrutinib) for all approved indications (Press release, BeOne Medicines, AUG 21, 2025, View Source [SID1234655427]).

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"Developed to meet the real-world needs of patients, the new BRUKINSA tablet formulation aims to simplify treatment, reduce pill burden, and enhance ease of administration, reflecting our continuous focus on patient-centered innovation," said Giancarlo Benelli, Senior Vice President and Head of Europe, BeOne. "With more than 200,000 patients treated globally and the broadest label of any BTK inhibitor in Europe, BRUKINSA’s differentiated clinical profile continues to make an impact for people facing certain B-cell cancers."

The recommended dose of BRUKINSA continues to be 320 mg daily. The BRUKINSA tablets are 160 mg each, allowing patients to halve their daily pill intake from four pills to two. Additionally, they are smaller than the capsules and have film coatings, which make them easier to swallow.

Important Safety Information

The current European Summary of Product Characteristics (SmPC) of BRUKINSA is available from the website of the European Medicines Agency.

The information provided in this press release is intended for a global audience.

About BRUKINSA (zanubrutinib)

BRUKINSA is an orally available, small molecule inhibitor of Bruton’s tyrosine kinase (BTK) designed to deliver complete and sustained inhibition of the BTK protein by optimizing bioavailability, half-life, and selectivity. With differentiated pharmacokinetics compared with other approved BTK inhibitors, BRUKINSA has been demonstrated to inhibit the proliferation of malignant B cells within a number of disease-relevant tissues.

BRUKINSA has the broadest label globally of any BTK inhibitor and is the only BTK inhibitor to provide the flexibility of once or twice daily dosing. Additionally, BRUKINSA is the only BTK inhibitor to demonstrate PFS superiority to a first-generation BTK inhibitor in a Phase 3 study.

The global BRUKINSA clinical development program includes approximately 7,100 patients enrolled in 30 countries and regions across more than 35 trials. BRUKINSA is approved for at least one indication in more than 75 markets, and more than 200,000 patients have been treated globally.