On February 17, 2026 Incyte (Nasdaq:INCY) reported that it will present at the following investor conferences during the month of March:

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TD Cowen 46th Annual Health Care Conference on Monday, March 2, 2026 at 10:30 am (EST)

Leerink Partners 2026 Global Healthcare Conference on Tuesday, March 10, 2026 at 9:20 am (EDT) and

Barclays 28th Annual Global Healthcare Conference on Wednesday, March 11, 2026 at 8:30 am (EDT)
The presentations will be webcast live and can be accessed at Investor.Incyte.com and will be available for replay for 30 days.

(Press release, Incyte, FEB 17, 2026, View Source [SID1234662739])

On February 17, 2026, Amgen Inc. (the "Company") issued and sold $1,000,000,000 aggregate principal amount of the Company’s 4.200% Senior Notes due 2031 (the "2031 Notes"), $1,750,000,000 aggregate principal amount of the Company’s 4.850% Senior Notes due 2036 (the "2036 Notes"), $500,000,000 aggregate principal amount of the Company’s 5.500% Senior Notes due 2046 (the "2046 Notes") and $750,000,000 aggregate principal amount of the Company’s 5.650% Senior Notes due 2056 (the "2056 Notes" and, together with the 2031 Notes, the 2036 Notes and the 2046 Notes, the "Notes"). The Notes are registered under an effective Registration Statement on Form S-3 (Registration No. 333-293477) (the "Registration Statement"), filed on February 13, 2026, and were issued pursuant to an indenture, dated as of May 22, 2014 (the "Indenture"), between the Company and The Bank of New York Mellon Trust Company, N.A., as trustee, and an officer’s certificate, dated as of February 19, 2026 (the "Officer’s Certificate"), setting forth the terms of the Notes. Net proceeds to the Company from the offering were approximately $3,961,495,000, after deducting underwriters’ discounts and estimated offering expenses payable by the Company.

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The relevant terms of the Notes are set forth in the Indenture, included as Exhibit 4.1 of the Company’s Current Report on Form 8-K, filed on May 22, 2014, and incorporated herein by reference, and the Officer’s Certificate (including the forms of the Notes) attached hereto as Exhibit 4.2 and incorporated herein by reference.

The 2031 Notes will pay interest at the rate of 4.200% per annum, the 2036 Notes will pay interest at the rate of 4.850% per annum, the 2046 Notes will pay interest at the rate of 5.500% per annum and the 2056 Notes will pay interest at the rate of 5.650% per annum, which shall be payable in cash semi-annually in arrears on February 19 and August 19 of each year, beginning on August 19, 2026. The 2031 Notes will mature on February 19, 2031, the 2036 Notes will mature on February 19, 2036, the 2046 Notes will mature on February 19, 2046 and the 2056 Notes will mature on February 19, 2056.

In the event of a change in control triggering event, as defined in the Officer’s Certificate, the holders of the Notes may require the Company to purchase for cash all or a portion of their Notes at a purchase price equal to 101% of the principal amount of Notes, plus accrued and unpaid interest, if any. The descriptions of the Indenture, the Officer’s Certificate and the Notes in this report are summaries and are qualified in their entirety by the terms of the Indenture, the Officer’s Certificate and the Notes, respectively.

The Notes will rank equal in right of payment to all of the Company’s other existing and future senior unsecured indebtedness, senior in right of payment to all of the Company’s existing and future subordinated indebtedness, effectively subordinated in right of payment to all of the Company’s subsidiaries’ obligations (including secured and unsecured obligations) and subordinated in right of payment to the Company’s secured obligations, to the extent of the assets securing such obligations.

(Filing, Amgen, FEB 17, 2026, View Source [SID1234662780])

On February 17, 2026 Cellectar Biosciences, Inc. (NASDAQ: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery and development of drugs for the treatment of cancer, reported a broad expansion of its global intellectual property (IP) estate, including newly issued patents across Europe, Asia-Pacific, the Middle East, and the Americas. These additions strengthen the company’s protection around iopofosine I 131, its proprietary radiotherapeutic, as well as its broader portfolio, including CLR 125, the company’s Auger-emitting radiopharmaceutical in development as a treatment for triple negative breast cancer.

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"We are seeing meaningful and timely momentum across our global IP estate at a truly pivotal moment for the company," said James Caruso, president and CEO of Cellectar Biosciences. "Securing these patents in major international markets reinforces the uniqueness of our technology and provides critical intellectual property fortification. Following guidance from the EMA’s Scientific Advice Working Party (SAWP) we are advancing our planned filing for conditional marketing authorization of iopofosine I 131 for Waldenström macroglobulinemia in Europe. This strengthened global protection is essential to our long-term commercial strategy—and, more importantly, it supports our commitment to delivering new, desperately needed therapeutic options to patients who continue to face limited treatment choices."

The expanded IP coverage spans multiple patent families critical to the company’s therapeutic and platform strategies:

Ether and Alkyl Phospholipid Compounds for Treating Cancer and Imaging Cancer Stem Cells
Covers iopofosine I 131 and CLR-125 for both therapeutic use and imaging/detection of primary tumors and cancer stem cells.
Newly issued in Europe, China, Israel, Eurasia, and New Zealand.
Fractionated Dosing of a Phospholipid Ether Analog for the Treatment of Cancer
Covers proprietary iopofosine I 131 dosing regimens.
Newly issued in Eurasia, Israel, Turkey, Mexico, and Canada.

(Press release, Cellectar Biosciences, FEB 17, 2026, View Source [SID1234662706])

On February 17, 2026 Omeros Corporation (NASDAQ: OMER) reported the successful completion of its initial study in nonhuman primates evaluating the efficacy and safety of its OncotoX-AML cancer therapeutic platform. Omeros’ OncotoX-AML therapeutic is first targeting acute myeloid leukemia (AML), an aggressive and highly fatal bone marrow and blood cancer. The effectiveness of current AML treatments, such as chemotherapeutics and antibody-drug conjugates, are limited by substantial side effects. Administration of only one course of OncotoX-AML treatment to immunocompetent primates demonstrated the desired pharmacologic response, specifically marked, selective, reversible, and dose-related reduction in myeloid progenitor cells — the cells that can mutate and lead to AML — by up to 99 percent. OncotoX-AML was well tolerated, without causing broader or lasting hematologic changes while preserving hematopoietic stem cells. There were no observed safety signals or meaningful changes in blood chemistry values often seen with current AML treatments.

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OncotoX-AML is an engineered biologic designed to selectively kill both AML blasts (abnormal myeloid cells) and relapse-related leukemia stem cells. Its unique mechanism of action is independent of myeloid cell genetic mutations, including TP53, NPM1, KMT2A, and FLT3, collectively found in approximately 90 percent of AML patients. In preclinical studies using patient-derived AML cells, OncotoX-AML molecules preferentially and efficiently killed myeloid cancer cells regardless of their respective mutational signature.

In multiple in vivo murine-human xenograft models, OncotoX-AML treatment consistently demonstrated superior efficacy compared to the current AML standard-of-care, namely the combination of venetoclax and azacitidine (VenAza). Across these various models, OncotoX-AML eradicated all disseminated tumors, extending survival in all animals to over 100 days without evidence of tumor recurrence, compared to a median survival increase of 8 days with VenAza. Omeros is now initiating IND-enabling studies to bring OncotoX-AML to the clinic.

"We’re excited by these data — both the efficacy results and the absence of any meaningful safety signal," stated Gregory A. Demopulos, M.D., Chairman and Chief Executive Officer of Omeros. "With the guidance of our distinguished advisory board of AML experts, we look forward to advancing OncotoX-AML to the clinic, targeting a first-in-human trial for late 2027."

AML is estimated to have been responsible for over 11,000 U.S. deaths in 2025.

(Press release, Omeros, FEB 17, 2026, View Source [SID1234662724])

On February 17, 2026 Deciphera Pharmaceuticals, a member of Ono Pharmaceutical Co., Ltd. (Headquarters: Osaka, Japan; President and COO: Toichi Takino; "Ono"), reported that the U.S. Food and Drug Administration (FDA) has accepted for filing the New Drug Application (NDA) under the accelerated approval pathway for tirabrutinib, a highly selective irreversible, second generation Bruton tyrosine kinase inhibitor, for the treatment of relapsed or refractory primary central nervous system lymphoma (R/R PCNSL). The FDA has set an action date of December 18, 2026, under the Prescription Drug User Fee Act (PDUFA).

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"R/R PCNSL is a rare and aggressive form of non-Hodgkin lymphoma with particularly poor clinical outcomes. Patients often experience difficulty and delay in diagnosis, and once they are diagnosed, there is a high unmet need for a treatment with a favorable safety profile," said Matthew L. Sherman, M.D., Chief Medical Officer of Deciphera. "The FDA’s acceptance of tirabrutinib’s NDA for filing is an exciting milestone as it brings us one step closer to our goal of providing patients with R/R PCNSL an important new treatment option."

"We are very pleased that the NDA for tirabrutinib has been accepted for filing," said Toichi Takino, President and COO of Ono Pharmaceutical Co., Ltd. "This is an important milestone on the way to expanding our commercial pipeline and achieving our goal of becoming a global specialty pharma. Tirabrutinib’s potential to address unmet patient needs embodies our corporate philosophy and we will continue to focus on developing and delivering innovative medicines to benefit patients worldwide."

The NDA is supported by the positive results from the Phase 2 PROSPECT study, presented at the 2025 American Society for Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, in which tirabrutinib demonstrated an overall response rate of 67%, a complete response rate of 44%, and a manageable safety profile. If approved, tirabrutinib will be the first BTK inhibitor therapy commercially available in the U.S. for the treatment of patients with R/R PCNSL, and the third commercial therapy for Ono group available in the U.S. The study is currently recruiting patients with R/R PCNSL in a global Phase 3 randomized trial, which will serve as a confirmatory study for this indication (ClinicalTrials.gov NCT07104032.)

About Tirabrutinib

Tirabrutinib, discovered and developed by Ono Pharmaceutical Co., Ltd., is a highly potent selective BTK inhibitor. Signaling through the B-cell receptor (BCR) regulates cellular proliferation and activation, and promotes survival, differentiation, and clonal expansion of B-cells. The BCR signaling pathway plays an important role in a number of B-cell malignancies. In Japan, tirabrutinib was approved in March 2020 for the treatment of R/R PCNSL and launched under the tradename of Velexbru in May 2020. It was subsequently approved for the treatment of Waldenstrom macroglobulinemia and lymphoplasmacytic lymphoma in August 2020. Tirabrutinib was approved for the treatment of R/R PCNSL in South Korea in November 2021 and in Taiwan in February 2022.

About PCNSL

PCNSL is a rare and aggressive extra-nodal non-Hodgkin lymphoma (NHL) that is confined to the brain parenchyma, spinal cord, eye, or leptomeninges without systemic involvement. The annual incidence rate of PCNSL is approximately five cases per 1,000,000 people in the U.S. The rate can further increase among immuno-compromised people aged 65 years and older. The signs and symptoms presented in patients with PCNSL vary depending on the neuroanatomical site of the lesion, and include cranial neuropathy, neuropsychiatric symptoms, symptoms associated with increased intracranial pressure, seizures, ocular symptoms, headache, dysmotility, cranial neuropathy, and radiculopathy. There is a high unmet need for a treatment with a favorable safety profile, and data guiding therapeutic approaches are very limited. Despite recent progress resulting in the improvement of clinical outcomes in newly diagnosed patients with PCNSL after an induction treatment, approximately 20 to 30 percent of patients are refractory to the initial treatment, and up to 60 percent of patients will eventually relapse. To learn more about R/R PCNSL, please visit navigatingpcnsl.com.

(Press release, Deciphera Pharmaceuticals, FEB 17, 2026, View Source [SID1234662740])