Harpoon Therapeutics Announces Pricing of Public Offering of Common Stock

On January 6, 2021 Harpoon Therapeutics, Inc. (Nasdaq: HARP), reported the pricing of an underwritten public offering of 5,882,352 shares of its common stock at a price to the public of $17.00 per share (Press release, Harpoon Therapeutics, JAN 6, 2021, View Source [SID1234573634]). Harpoon Therapeutics expects that the gross proceeds from the sale of the shares will be approximately $100.0 million, before deducting underwriting discounts and commissions and offering expenses payable by Harpoon Therapeutics. In addition, Harpoon Therapeutics has granted the underwriters in the offering a 30-day option to purchase up to 882,352 additional shares of common stock at the public offering price. The offering is expected to close on January 11, 2021, subject to customary closing conditions.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Harpoon Therapeutics plans to use the net proceeds of the offering, together with other available funds, to fund the continued clinical development of HPN424 in metastatic castration-resistant prostate cancer, HPN536 in ovarian cancer and other solid tumors, HPN217 in multiple myeloma, and HPN328 for the treatment of small cell lung cancer and other neuroendocrine tumors expressing Delta-like canonical Notch ligand 3; to advance the development of other pipeline candidates, including HPN601; and for working capital and general corporate purposes.

SVB Leerink and Piper Sandler are acting as joint bookrunning managers for the offering. Baird and Truist Securities are acting as co-lead managers for the offering. Roth Capital Partners is acting as co-manager for the offering.

The shares of common stock are being offered pursuant to a "shelf" registration statement previously filed with and declared effective by the Securities and Exchange Commission (SEC). Harpoon Therapeutics has filed a preliminary prospectus supplement and the accompanying prospectus related to the offering with the SEC, which are available on the SEC’s website, located at www.sec.gov. Copies of the final prospectus supplement relating to this offering, when available, and the accompanying prospectus may be obtained from: SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808-7525, ext. 6132 or by email at [email protected] or Piper Sandler & Co., Attention: Prospectus Department, 800 Nicollet Mall, J12S03, Minneapolis, MN 55402, by telephone at (800) 747-3924 or by email at [email protected].

This press release shall not constitute an offer to sell, or a solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. Any offer, if at all, will be made only by means of a prospectus supplement and accompanying prospectus, which are a part of the effective registration statement.

Pacylex Pharmaceuticals Announces Publication in Breast Cancer Research and Treatment of a New Target for Therapeutic Intervention in Breast Cancer and Preclinical Results of a First-in-Class Therapy

On January 6, 2021 Pacylex Pharmaceuticals, an oncology company unlocking a new approach to cancer therapy, reported the publication in the journal Breast Cancer Research and Treatment data showing treatment with an N-myristoyltransferase (NMT) inhibitor reduces viability of cultured breast cancer cells and inhibits tumor growth in a mouse xenograft mouse model of human breast cancer (Press release, Pacylex Pharmaceuticals, JAN 6, 2021, View Source [SID1234645065]). Pacylex is developing this NMT inhibitor, PCLX-001, as a first in class therapy for various leukemias and lymphomas and also plans to study its effects on various solid tumors.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"Despite the critical role myristoylation plays in cell survival, NMT1 and NMT2 protein levels have never been systematically studied in a large series of human cancers," said John Mackey, MD, Co-founder and Chief Medical Officer of Pacylex and first author on the paper. "Not only did we find a relationship between NMT2 levels and patient survival, but an NMT inhibitor was generally effective against breast cancer cell lines and inhibited human breast cancers grown in mice."

Dr. Mackey and colleagues studied the abundance and distribution of NMT1 and NMT2 proteins in normal breast tissue and a large cohort of primary breast adenocarcinomas from a prospective phase III clinical trial (n=706). NMT1 protein was observed in normal and most transformed breast epithelial tissue and was associated with better overall histologic grade, higher Ki67, and lower hormone expression. Though NMT2 protein was readily detected in normal breast epithelial tissue, it was undetectable in the majority of breast cancers. Detectable NMT2 protein correlated with significantly worse overall survival.

This extends the proof-of-concept for NMT inhibitors as potential cancer therapeutics for blood cancers, recently published in Nature Communications, to solid tumors as well, and supports the continued preparation for the first human clinical trial set to begin in early 2021. Both lymphoma and solid tumor patients including breast cancer will be enrolled in this initial study.

A link to the publication "N-myristoyltransferase proteins in breast cancer: prognostic relevance and validation as a new drug target" can be accessed here. The Alberta Cancer Foundation and the Cure Cancer Foundation both provided support for this research.

PCLX-001

PCLX-001 is a small molecule, first-in-class myristoylation inhibitor, originally developed by the University of Dundee Drug Discovery Unit as part of a program to treat African sleeping sickness funded by Wellcome Trust. Pacylex is developing PCLX-001, which has very good oral bioavailabilty, to treat cancers low in N-myristoyltransferase 2 (NMT2), a myristoylation enzyme whose deficiency is associated with higher mortality in leukemia and lymphoma. PCLX-001 selectively kills cancer cells and completely regresses (eliminates) tumors in animal models of acute myeloid leukemia (AML), diffuse large B-cell lymphoma (DLBCL) and Burkitt’s lymphoma (BL). PCLX-001 has also been shown to inhibit the growth of lung and breast cancer tumors in animal models. In tests using cultured cancer cells in vitro, PCLX-001 is at least ten times as potent as Ibrutinib (Imbruvica) and Dasatinib (Sprycel), two clinically approved drugs currently used to treat hematologic malignancies.

Akari Therapeutics to Participate in Two January Virtual Investor Conferences

On January 6, 2021 Akari Therapeutics, Plc (Nasdaq: AKTX), a late-stage biopharmaceutical company focused on innovative therapeutics to treat orphan autoimmune and inflammatory diseases where complement (C5) and/or leukotriene (LTB4) systems are implicated, reported that Clive Richardson, Chief Executive Officer, will participate in the following two upcoming virtual investor conferences (Press release, Akari Therapeutics, JAN 6, 2021, View Source [SID1234573545]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Conference: H.C. Wainwright BioConnect Conference

Date & Time: The Company’s presentation will be available on demand starting January 11, 2021 through the Company’s website.

Conference: ICR Conference 2021

Date & Time: Thursday, January 14, 2021 at 10:00 a.m. ET.

Investors interested in arranging a virtual meeting with the Company’s management during the ICR Conference 2021 should contact the ICR conference coordinator or [email protected]. Webcasts of both presentations will be available by visiting ‘Events’ in the Investor Relations section on the Company’s website at www.akaritx.com.

ImmunoPrecise Antibodies to Participate in January Conferences

On January 6, 2021 IMMUNOPRECISE ANTIBODIES LTD. ("IPA") (Nasdaq: IPA) (TSXV: IPA) a leader in full-service, therapeutic antibody discovery, reported that Dr. Jennifer Bath, ImmunoPrecise’s Chief Executive Officer, will participate in a pre-recorded presentation through the H.C. Wainwright BioConnect 2021 Conference, and management will host one-on-one meetings with investors through the Stern IR Virtual Corporate Access Event, both taking place January 11-14, 2021 (Press release, ImmunoPrecise Antibodies, JAN 6, 2021, View Source [SID1234573579]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The H.C. Wainwright presentation will be available for on-demand viewing beginning Monday, January 11, 2021 at 6:00 a.m. ET. The recording can be accessed via H.C. Wainwright BioConnect website at and will be available for approximately 30 days.

OBI Pharma, Inc. to Present at the 39th J.P. Morgan Healthcare Conference

On January 6, 2021 OBI Pharma, Inc., a Taiwan biopharma company (TPEx: 4174), reported that Tillman Pearce, MD., Chief Medical Officer, will present a company and clinical development overview at the 39th Annual J.P. Morgan Digital Healthcare Conference on Monday, January 11, 2021 at 11:00 a.m. EST/ 8:00 a.m. PST (Press release, OBI Pharma, JAN 6, 2021, View Source [SID1234573596]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The presentation slides will be available online at www.obipharma.com on January 12, 2021.