XNK Therapeutics partners with Cellect for next generation platform development

On December 11, 2020 XNK Therapeutics AB ("XNK") reported its collaboration agreement with Israel-based Cellect Biotechnology ("Cellect") to develop the next generation version of XNK’s innovative technology platform (Press release, CellProtect Nordic Pharmaceuticals, DEC 11, 2020, View Source [SID1234574490]).

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Under the terms of the agreement, Cellect will work to further improve XNK Therapeutics’ technology platform for targeting cancer across a wide range of indications. Cellect’s functional cell selection technology has the potential to significantly improve the consistency and manufacturing efficiency in autologous cell therapies.

"I am excited that we will be able to continue developing the next generation of XNK Therapeutics’ technology platform in collaboration with Cellect," said Johan Liwing, CEO of XNK Therapeutics.

"We recognize the growing interest in NK cells and decided to work with XNK Therapeutics for further dissemination of our Apograft technology," said Dr. Shai Yarkoni, CEO of Cellect Biotechnology.

IGM Announces Closing of $230 Million Public Offering and Full Exercise of Underwriters’ Option to Purchase Additional Shares

On December 11, 2020 IGM Biosciences, Inc. (NASDAQ: IGMS) (IGM) reported the closing of its upsized underwritten public offering of 1,221,224 shares of its common stock, which includes the exercise of the underwriters’ option to purchase additional shares in full, and pre-funded warrants to purchase 1,334,332 shares of its common stock (Press release, IGM Biosciences, DEC 11, 2020, View Source [SID1234572666]). The public offering price of common stock was $90.00 per share and the public offering price of each pre-funded warrant was $89.99, with each pre-funded warrant having an exercise price of $0.01. The aggregate gross proceeds to IGM from the offering were approximately $230 million, before deducting the underwriting discounts and commissions and other offering expenses payable by IGM.

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Jefferies, Stifel, Guggenheim Securities and RBC Capital Markets acted as joint book-running managers for the offering. Baird and Truist Securities acted as the lead managers for the offering.

The securities were offered by IGM pursuant to a Registration Statement on Form S-3 filed with the Securities and Exchange Commission (SEC) on November 5, 2020, which became effective on November 12, 2020. A final prospectus supplement and accompanying prospectus relating to the offering, was filed with the SEC on December 8, 2020, copies of which can be accessed for free through the SEC’s website at www.sec.gov. Additionally, when available, copies of the final prospectus supplement and the accompanying prospectus relating to the offering may also be obtained by request from: Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, by telephone at (877) 821-7388 or by email at [email protected]; Stifel, Nicolaus & Company, Incorporated, Attention: Syndicate, One Montgomery Street, Suite 3700, San Francisco, CA 94104, by telephone at (415) 364-2720 or by email at [email protected]; Guggenheim Securities, LLC, Attention: Equity Syndicate Department, 330 Madison, 8th Floor, New York, NY 10017, by telephone at (212) 518-9658 or by email at [email protected]; or RBC Capital Markets, LLC, 200 Vesey Street, 8th Floor, New York, NY 10281-8098; Attention: Equity Syndicate; by telephone at (877) 822-4089 or by email at [email protected].

This press release does not constitute an offer to sell or a solicitation of an offer to buy, nor will there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation, or sale would be unlawful before registration or qualification under the securities laws of that state or jurisdiction.

CEL-SCI Announces the Closing of Its $14.65 Million Bought Deal

On December 11, 2020 CEL-SCI Corporation (NYSE American: CVM), a Phase 3 cancer immunotherapy company, reported the closing of the offering of 1,000,000 shares of its common stock at a price of $14.65 per share, for total gross proceeds of $14.65 million, before deducting underwriting discounts and other offering expenses payable by the Company (Press release, Cel-Sci, DEC 11, 2020, View Source [SID1234572697]). Additionally, the Company has granted the underwriter a 30-day option to purchase up to 150,000 additional shares to cover over-allotments.

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Kingswood Capital Markets, division of Benchmark Investments, Inc. and Aegis Capital Corp. acted as the joint book-running managers for the offering.

This offering was made pursuant to a "shelf" registration statement on Form S-3 (File No. 333-226558) filed with the Securities and Exchange Commission (SEC). A prospectus supplement and accompanying base prospectus relating to the offering were filed with the SEC and are available on the SEC’s website at View Source and may be obtained from Kingswood Capital Markets, Attention: Syndicate Desk, 17 Battery Place, Suite 625, New York, NY 10004, by email at [email protected], or by telephone at (212) 404-7002.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy any of the securities described herein, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

BiOrion Technologies receives a EUROSTARS grant for their € 1.7 M colorectal cancer imaging program COLOSELECT

On December 11, 2020 BiOrion reported The EUROSTARS grant of a EUR 1.7 million colorectal cancer imaging program is awarded to a multidisciplinary consortium including BiOrion Technologies BV, The Netherlands (Press release, BiOrion, DEC 11, 2020, View Source [SID1234575366]).

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EUROSTARS is a joint program between EUREKA and the European Commission, co-funded from the national budgets of 36 EUROSTARS Participating States and Partner Countries and by the European Union through Horizon 2020. The subsidy is for a three-year period and will allow clinical development of PDGF beta receptor binding single domain antibodies conjugated to PET-imaging and therapeutic radionuclides and to target fibrotic stroma in advanced colorectal cancer.

Herman Steen, CEO of BiOrion, "We are delighted with the recognition and support for our PDGF beta receptor binding single domain antibodies targeting program by EUROSTARS. This strong and synergistic consortium will enable BiOrion to progress clinical development of our novel targeted imaging diagnostics and therapeutics against fibrotic stroma of solid cancers."

Arvinas to Host Webcast Presentation of New Clinical Data from ARV-471 and ARV-110 PROTAC® Protein Degrader Development Programs

On December 11, 2020 Arvinas, Inc. (Nasdaq: ARVN), a clinical-stage biotechnology company creating a new class of drugs based on targeted protein degradation, reported that it will host a live webcast presentation on Monday, December 14, 2020 at 8:00 a.m. ET to provide clinical program updates for its PROTAC protein degraders ARV-471 and ARV-110 (Press release, Arvinas, DEC 11, 2020, View Source [SID1234572669]). The presentation will include updates from the Phase 1 dose escalation studies of ARV-471 in patients with locally advanced or metastatic ER positive / HER2 negative breast cancer and ARV-110 in men with metastatic castrate-resistant prostate cancer. The event will also include an overview of the recently initiated Phase 2 dose expansion study for ARV-110.

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The live webcast presentation will be available here or on the Company’s website at www.arvinas.com under Events + Presentations. To access the event via dial-in, please dial (844) 467-7654 (domestic) or (602) 563-8497 (international) and refer to conference ID 9681734. A replay of the webcast will be archived on the Arvinas website following the presentation.