On October 12, 2020 Evotec SE (FSE:EVT)(OTC PINK:EVTCY)(MDAX/TecDAX, ISIN: DE0005664809, WKN 566480) reported that it resolved on a capital increase from its authorised capital without pre-emptive rights against cash (Press release, Evotec, OCT 12, 2020, View Source;announcements/ad-hoc-releases/p/mubadala-investment-company-and-novo-holdings-as-invest-eur-250-million-in-evotec-se-5980 [SID1234568334]). Evotec will issue a total of 11,478,315 new shares to Mubadala Investment Company and Novo Holdings A/S.

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In this private capital increase, Mubadala Investment Company will invest € 200 million to subscribe 9,182,652 Evotec shares at a share price of € 21.7802 per share representing approx. 5.6% of outstanding shares. Evotec gains with Mubadala Investment Company a new long-term strategic oriented shareholder with extensive experience and expertise in the biotech industry. Evotec’s existing long-term shareholder Novo Holdings A/S will invest € 50 million to subscribe 2,295,663 shares of Evotec at a same share price to reinforce its ownership at approx. 11.0%, to secure financial flexibility for the Company.

The placement was made at 2.5% discount to the five-day volume weighted average price ("VWAP") of € 22.3387 prior to the Xetra closing auction on 12th October 2020. After the registration of the capital increase in the commercial register, the share capital of the Company will increase to € 163,375,808 or 163,375,808 ordinary bearer shares.

While maintaining the business outlook 2020 unchanged, Evotec will be using the proceeds from the capital increase to pursue its unique strategy to become the global leading platform company for the modality-agnostic development of innovative first-in-class and best-in-class therapeutic approaches resulting in a very large co-owned pipeline.

On October 12, 2020 Rhizen Pharmaceuticals S. A. (Rhizen), a Switzerland-based privately held clinical-stage biopharmaceutical company, and Curon Biopharmaceutical Limited (Curon), a clinical-stage innovative biopharmaceutical company with facility in Shanghai reported that they have entered into an exclusive licensing agreement for the development and commercialization of Tenalisib, a dual PI3K delta & gamma inhibitor in the Greater China region (Press release, Rhizen Pharmaceuticals, OCT 12, 2020, View Source [SID1234568376]).

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Under the terms of the agreement, Rhizen will receive an undisclosed upfront cash payment and is eligible to receive additional development and commercial milestone payments with an overall deal value of USD 149.5 million plus double-digit royalties on annual net sales of Tenalisib.

Curon obtains the exclusive development and commercialization rights of Tenalisib for Greater China across all oncology indications, and will lead the clinical development in that territory by leveraging its unique expertise in translational research, clinical development and regulatory registration and its extensive research collaboration experience, to accelerate the development of and regulatory approval of this product in Greater China.

Swaroop Vakkalanka, Ph.D., President and Chief Executive Officer of Rhizen Pharmaceuticals stated, "Emerging human clinical data demonstrates that Tenalisib is a differentiated, next-generation, orally active, dual PI3K delta and gamma inhibitor with an excellent safety profile and promising single-agent activity in haeme malignancies. We believe, Tenalisib’s outstanding safety could allow rational combinations with other approved/investigational agents and enable us to unlock the true potential of this class of drugs. Our partnering with Curon is a first step towards achieving this objective and we look forward to the day this novel drug reaches cancer patients in need of new and safe therapies."

"Tenalisib has demonstrated great efficacy in lymphoma patients with outstanding safety profile, in-licensing this product to China would bring more effective and additional treatment options to Chinese cancer patients and greatly benefit these patients. Meanwhile, this will further enrich our diversified pipeline. We are very happy and look forward to closely collaborating with Rhizen to efficiently develop this molecule into an effective medicine to benefit patients not only in China but also around the world as soon as possible." said Zhihong Chen, Ph.D., President of Curon.

Kun Tao from Yafo Capital acted as financial advisor on this transaction for Rhizen.

About Tenalisib (RP6530):

Tenalisib (RP6530) is a highly selective, next-generation, orally active, dual PI3K delta and gamma inhibitor, that is currently in Phase 2 clinical development for hematological malignancies. Tenalisib has been granted US FDA Fast Track & Orphan-Drug Designations for treatment of relapsed/refractory peripheral T-cell lymphoma and cutaneous T-cell lymphoma (R/R PTCL and R/R CTCL).

On October 12, 2020 4SC AG (4SC, FSE Prime Standard: VSC) reported the availability of a new publication on domatinostat in the Journal of Investigative Dermatology entitled "The HDAC Inhibitor Domatinostat Promotes Cell Cycle Arrest, Induces Apoptosis and Increases Immunogenicity of Merkel Cell Carcinoma Cells" (Press release, 4SC, OCT 12, 2020, View Source [SID1234568338]). The article was published by the Research Group of Professor J. C. Becker, Department of Translational Skin Cancer Research, Essen, Germany and is freely accessible via View Source(20)32074-1/fulltext or via the 4SC homepage.

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The article presents preclinical data demonstrating domatinostat´s efficacy and mode of action in Merkel Cell Carcinoma (MCC). The data shows that domatinostat not only exerts direct anti-tumoral effects, but also restores HLA class I surface expression on MCC cells – and as a result, restores surviving MCC cells’ susceptibility to recognition and elimination by cytotoxic T cells.

Frank Hermann, MD, Chief Development Officer at 4SC commented: "The preclinical results published in this article strongly support our clinical development strategy to combine domatinostat with avelumab in patients with advanced MCC – to effectively address critical escape mechanisms in this deadly cancer and synergize with immune checkpoint blockade. We acknowledge the scientific value and relevance of the work of Professor Becker and his research team, and look forward to seeing clinical data from our MERKLIN 2 and MERKLIN 1 studies."

On October 12, 2020 ImmunoGen, Inc. (Nasdaq: IMGN), a leader in the expanding field of antibody-drug conjugates (ADCs) for the treatment of cancer, reported that it has raised gross proceeds of approximately $54.8 million through its At-the-Market ("ATM") facility pursuant to its Open Market Sale AgreementSM dated as of September 25, 2020 with Jefferies LLC, as sales agent (the "Sale Agreement"), with participation based on interest received from multiple institutional investors (Press release, ImmunoGen, OCT 12, 2020, View Source [SID1234568340]). On October 9, 2020, the Company sold approximately 12.7 million shares of the Company’s common stock at a per share purchase price of $4.33, the market price at the time of sale.

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The additional funds raised through the ATM strengthen the Company’s balance sheet and will be used to fund the Company’s operations, including, but not limited to, clinical trial activities, supply of drug substance and drug product, pre-commercialization and commercialization activities, capital expenditures, and working capital.

The shares of common stock described above were sold pursuant to the Company’s shelf registration statement on Form S-3 (File No. 333-223507), previously filed with the Securities and Exchange Commission ("SEC") on March 7, 2018, which became effective upon filing, and a prospectus supplement dated September 25, 2020 and the accompanying prospectus the Company filed with the SEC in connection with the offer and sale of the Company’s common stock pursuant to the Sale Agreement. Copies of the prospectus supplement and the accompanying prospectus may be obtained from Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, by e-mail at [email protected] or by telephone at (877) 821-7388. Electronic copies of the prospectus supplement and the accompanying prospectus are also available on the SEC’s website at View Source

On October 12, 2020 Prescient Therapeutics reported that attention for its remarkable progress on the development of a broad pipeline for personalised cancer treatments (Press release, Prescient Therapeutics, OCT 12, 2020, View Source;utm_medium=rss&utm_campaign=shedding-light-on-prescient-therapeutics-ptx-personalised-cancer-treatments [SID1234568605]).

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Personalised cancer treatments of PTX comprises CAR-T and targeted therapies spanning several challenging cancers. Prescient Therapeutics has licensed technologies and collaborations with world-leading cancer centres in the U.S.

Let us deep dive and discuss product pipeline of Prescient Therapeutics-

Universal immune receptor platform, OmniCAR

OmniCAR is a universal immune receptor platform creating next-generation CAR-T therapies. Whilst CAR-T has represented a paradigm-shift in treating cancer, current generation CAR-T is faced with many limitations including safety and flexibility in targeting other cancers.

This is where OmniCAR comes in, creating next-genreation CAR-T that addresses the limitations of current generation CAR-T. OmniCARenables controllable T-cell activity & multi-antigen targeting with a single cell product. The modular CAR system of OmniCAR decouples antigen recognition from the T-cell signalling domain. This platform is based on technology licensed from the University of Pennsylvania and Oxford University.

The universal immune receptor platform allows extraordinary control and flexibility over the current generation CAR-T approaches. With OmniCAR, Prescient will enable its in-house development of next-generation engineered cell therapies. OmniCAR also creates opportunities in collaboration and business development for cell therapy area of Prescient.

Prescient is working with the goal of harnessing innate adaptability and control of OmniCAR for developing novel CAR-T products for new indications. OmniCAR platform improves the cost, time as well as the effectiveness of delivering CAR-T therapies across the world.

READ MORE: Prescient Collaborates With Peter MacCallum Cancer Centre

Moreover, Prescient has several other programs underway to develop new cell therapy methods.

First-in-class drug candidate, PTX-100
PTX-100 disrupts the oncogenic Ras pathway by preventing the activation of Rho, Rac and Ral, leading to cancer cells death. PTX-100 is under clinical development for hematological and solid malignancies under Phase 1b PK/PD basket study.

Currently, PTX is conducting its Phase 1b basket study of PTX-100 at a dose of 2,000 mg/m2.

In this study, Prescient is finding the mutational status of malignancies of each patient and aims to compare this status with any clinical activity. Moreover, the Company is investigating several cancer biomarkers with the objective of identifying patients who may be most likely to respond to PTX-100 therapy.

Novel PH domain inhibitor, PTX-200
A novel PH domain inhibitor PTX-200 inhibits Akt tumor survival pathway. This pathway has a significant role in the development of numerous cancers, including breast & ovarian cancer, along with acute myeloid leukemia (AML). With its novel mechanism of action, PTX-200 specifically inhibits Akt while being comparatively safe. Currently, Prescient is conducting Phase 1b study of PTX-200 & cytarabine in AML patients.

On 3 August 2020, the Company disclosed that it had completed the Phase 1b study for the first cohort at a dose of 25 mg/m2 PTX-200 under the revised study protocol. Currently, Prescient is conducting the Phase 1b study at the increased dose level of 35 mg/m2 PTX-200.

World-renowned leukemia expert Professor Jeffrey Lancet (H. Lee Moffitt Cancer Center, Florida) is leading the AML study.

COVID-19 Antiviral Testing Program
Addition to its personalised cancer treatments Prescient’s two assets are under evaluation against the deadly SARS-CoV-2. On 21 July 2020, Prescient Therapeutics disclosed that its two assets had been nominated as Group 1 priority candidates by Doherty Institute for a COVID-19 antiviral testing program. Both the assets of Prescient are selected on the basis of their potential antiviral properties.

On 12 October 2020, PTX share was trading at A$0.066, with a market capitalisation of A$41.64 million.

To know more about Prescient Therapeutics Limited, click here.

To stay updated with PTX company activities and announcements, please update your details on their investor centre.

Resilient Healthcare Stocks to Beat the Pandemic Heat
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