Oncternal Therapeutics to Participate in September Investor Conferences

On September 10, 2020 Oncternal Therapeutics (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, reported that management will participate in the following conferences in the month of September and invites investors to join by webcast (Press release, Oncternal Therapeutics, SEP 10, 2020, View Source [SID1234564959]). Please see additional details below:

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H.C. Wainwright 22nd Annual Global Investment Conference (Virtual)

Title:
Oncternal Therapeutics (ONCT) Company Presentation

Date:

Wednesday, September 16th, 2020

Time:

10:30 am Eastern Time

Presenter:

James Breitmeyer, President & CEO

Oppenheimer Fall Healthcare Life Sciences & MedTech Summit (Virtual)

Title:

Oncternal Therapeutics (ONCT) Company Presentation

Date:

Tuesday, September 22nd, 2020

Time:

4:10 pm Eastern Time

Presenter:

James Breitmeyer, President & CEO

Webcast Links:

Live webcasts of the presentations will be available online via a link from the investor relations page of the Company’s website at View Source, and the webcasts will be archived there for at least 30 days following the events.

DURECT Corporation to Participate in September Virtual Investor Conferences

On September 10, 2020 DURECT Corporation (Nasdaq: DRRX) reported that it will participate in the HC Wainwright 22nd Annual Global Investment Conference, Cantor Fitzgerald Virtual Global Healthcare Conference and Oppenheimer Fall Healthcare Life Sciences & MedTech Summit (Press release, DURECT, SEP 10, 2020, https://www.prnewswire.com/news-releases/durect-corporation-to-participate-in-september-virtual-investor-conferences-301127214.html [SID1234564976]).

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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HC Wainwright 22nd Annual Global Investment Conference
Date Monday, September 14
Time: 2:30-2:50 PM EDT (Fireside Chat with Ed Arce)
Webcast: View Source

Cantor Fitzgerald Virtual Global Healthcare Conference
Date Tuesday, September 15
Time 10-10:30am EDT (Fireside Chat with Ellie Merle)
Webcast: View Source

Oppenheimer Fall Healthcare Life Sciences & MedTech Summit
Date: Tuesday, September 22
Time: 11:40am-12:20pm EDT (Fireside chat with Francois Brisebois)
Webcast: View Source

TRILLIUM ANNOUNCES PRICING OF US$130 MILLION PUBLIC OFFERING OF COMMON SHARES

On September 10, 2020 Trillium Therapeutics Inc. ("Trillium" or the "Company") (NASDAQ/TSX: TRIL), a clinical stage immuno-oncology company developing innovative therapies for the treatment of cancer, reported that it has priced its previously announced underwritten public offering of 10,000,000 common shares (the "Common Shares") of the Company (the "Offering") (Press release, Trillium Therapeutics, SEP 10, 2020, View Source [SID1234564996]). The Common Shares are being sold at a public offering price of US$13.00 per Common Share.

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In connection with the Offering, Trillium has granted the underwriters a 30-day option to purchase up to an additional 1,500,000 Common Shares.

The gross proceeds to the Company from the Offering are expected to be approximately US$130 million, before deducting underwriting discounts and commissions and other estimated offering expenses. The Offering is expected to close on or around September 16, 2020, subject to the satisfaction of customary closing conditions.

The Company intends to use the net proceeds of the Offering for its ongoing and planned clinical trials for its CD47 program, including drug supply and for working capital and general corporate purposes.

Cowen and Evercore ISI are acting as joint book-running managers for the Offering. JMP Securities is acting as the lead manager and Ladenburg Thalmann and JonesTrading are acting as co-managers for the Offering.

No Common Shares will be offered or sold in Canada as part of this Offering. The Offering is subject to market conditions, as well as a number of closing conditions, including Nasdaq Capital Market ("Nasdaq") and Toronto Stock Exchange ("TSX") approvals, and there can be no assurance as to whether or when the Offering may be completed. For the purposes of TSX approval, the Company intends to rely on the exemption set forth in Section 602.1 of the TSX Company Manual, which provides that the TSX will not apply its standards to certain transactions involving eligible inter-listed issuers on a recognized exchange, such as Nasdaq.

The Offering is being made to purchasers outside of Canada pursuant to a U.S. registration statement on Form F-3 (File No. 333-237810), declared effective by the United States Securities and Exchange Commission (the "SEC") on May 4, 2020. A preliminary prospectus supplement dated September 9, 2020 has been filed with SEC relating to the Offering and a final prospectus supplement relating to the Offering will be filed with the SEC.

Before you invest, you should read the final prospectus supplement and the other documents the Company has filed for more complete information about the Company and the Offering. Copies of the final prospectus supplement will be available for free by visiting the SEC’s website at www.sec.gov or the Company’s profiles on the SEDAR website maintained by the Canadian Securities Administrators at www.sedar.com. Alternatively, copies of the final prospectus supplement will be available upon request by contacting Cowen and Company, LLC c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, Attn: Prospectus Department, by email at [email protected] or by telephone at (833) 297-2926 or by contacting Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 36th Floor, New York, New York 10055, or by telephone at (888) 474-0200, or by email at [email protected].

This press release does not constitute an offer to sell or the solicitation of an offer to buy securities, nor will there be any sale of the securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

AIM ImmunoTech to Present at the H.C. Wainwright 22nd Annual Global Investment Conference on September 14th

On September 10, 2020 AIM ImmunoTech Inc. (NYSE American:AIM) reported that the company will be presenting at the H.C. Wainwright Annual Global Investment Conference, being held virtually on September 14-16, 2020 (Press release, AIM ImmunoTech, SEP 10, 2020, https://aimimmuno.com/press-release/aim-immunotech-to-present-at-the-h-c-wainwright-22nd-annual-global-investment-conference-on-september-14th/ [SID1234569678]).

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Thomas K. Equels, Chief Executive Officer of AIM ImmunoTech, is scheduled to present on Monday, September 14 at 5:00 p.m., Eastern Time. The presentation will be webcast live on the conference event platform, which can be accessed here.

Advaxis Reports Third Quarter Ended July 31, 2020 Financial Results and Provides a Business Update

On September 10, 2020 Advaxis, Inc. (Nasdaq: ADXS), a clinical-stage biotechnology company focused on the development and commercialization of immunotherapy products reported an update on its clinical pipeline and financial results for the third quarter ended July 31, 2020 (Press release, Advaxis, SEP 10, 2020, View Source [SID1234564925]).

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Key recent corporate and clinical pipeline updates:

Presented updated clinical data from the ongoing Phase 1/2 trial of ADXS-503 in non-small cell lung cancer (NSCLC) demonstrating durable clinical benefit in two out of 3 evaluable patients with immediate prior progression on KEYTRUDA including one durable response now out to 34 weeks with 25% reduction in target lesion and another sustained response now out to 33 weeks with a 60% reduction in site lesions. Both patients remain on treatment in Part B, the combination arm with KEYTRUDA
Clinical benefit achieved after immediate prior progression on KEYTRUDA with previous best responses of stable disease suggest ADXS-503 may re-sensitize or enhance response to KEYTRUDA
Initiated ADXS-503 Part B combination arm efficacy expansion which will enroll up to 15 patients to evaluate the potential of ADXS-503 in combination with KEYTRUDA to restore and/or enhance responsiveness to checkpoint inhibitors in PD-1/L-1 refractory NSCLC patients
Initiated ADXS-503 Part C combination arm to evaluate ADXS-503 in combination with KEYTRUDA as a first line treatment in patients with NSCLC with PD-L1 expression ≥ 1% or who are unfit for chemotherapy
ADXS-503 monotherapy and in combination with KEYTRUDA appeared safe and well tolerated with no dose limiting toxicities or added toxicity in the combination setting
Announced common stock purchase agreement for up to $20 million with Lincoln Park Capital
Management Commentary
"We are highly encouraged by the clinical and on-mechanism biomarker data from our ongoing Phase 1/2 study of ADXS-503 in NSCLC and have continued to execute on our expansion of the evaluation of the potential of ADXS-503 to synergistically enhance and/or restore sensitivity to checkpoint inhibitors," said Kenneth A. Berlin, President and Chief Executive Officer of Advaxis. "This quarter, we have begun enrollment in the expansion of Part B to further evaluate the promising signals of sustained clinical benefit observed in the first dose cohort of Part B in NSCLC patients with immediate prior progression on KEYTRUDA. This could yet be another strategy to rechallenge the tumor with a checkpoint inhibitor without having to stop the drug at progression. In addition, we have started enrollment in Part C which will evaluate ADXS-503 in combination with KEYTRUDA, moving our HOT program to a first line treatment for patients with metastatic NSCLC that would receive KEYTRUDA alone as per label indication (i.e., PD-L1 expression ≥ 1%) and patients who are unfit to receive the standard of care regimen of KEYTRUDA in combination with platinum based-chemotherapy. We believe these two clinical evaluations in Part B and Part C of this study will elucidate the potential of ADXS-503 to improve responses to checkpoint inhibitors in diverse clinical settings and for patients who have limited treatment options. We anticipate having additional data on this program by the end of the year."

Mr. Berlin continued, "We are particularly encouraged by the safety and tolerability profile of ADXS-503 as a monotherapy and in combination KEYTRUDA, and with no dose limiting toxicities observed, we believe this can be an important addition to standard of care for those patients whose illness makes them ineligible for other forms of chemotherapy. Our recently announced common stock purchase agreement allows us to continue the prioritization of our HOT program with the ongoing expansions in NSCLC as well as the initiation of a Phase 1 study of ADXS-504 in prostate cancer patients with biochemical recurrence before year end."

Third Quarter Ended July 31, 2020 Financial Results

Research and development expenses for the third quarter of fiscal year 2020 were $3.5 million, compared with $7.1 million for the third quarter of fiscal year 2019. The decrease is largely attributable to the winding down of the Phase 3 AIM2CERV and Phase 1 ADXS-NEO studies as announced in June 2019 and October 2019, respectively.

General and administrative expenses for the three months ended July 31, 2020 were approximately $2.4 million compared to $3.1 million in the same three-month period in 2019. The decrease in expenses is mainly attributable to lower legal fees and business development costs.

As of July 31, 2020, the Company had approximately $23.8 million in cash and cash equivalents. The Company believes this is sufficient capital to fund its obligations, as they become due, in the ordinary course of business until July 2021.