Athenex, Inc. Announces Pricing of $110 Million Public Offering of Common Stock

On September 10, 2020 Athenex, Inc. (Nasdaq: ATNX), a global biopharmaceutical company dedicated to the discovery, development and commercialization of novel therapies for the treatment of cancer, reported the pricing of a public offering of 10,000,000 shares of its common stock at a public offering price of $11.00 per share (Press release, Athenex, SEP 10, 2020, View Source [SID1234573872]). The gross proceeds to Athenex from the offering, before underwriting discounts and commissions and estimated offering expenses, are expected to be $110 million. In addition, Athenex has granted the underwriters a 30-day option to purchase up to an additional 1,500,000 shares of common stock at the public offering price, less underwriting discounts and commissions. The offering is expected to close on September 14, 2020, subject to customary closing conditions.

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Athenex intends to use the net proceeds from the proposed offering to continue to expand and strengthen its commercial infrastructure, execute label expansion strategies for Oral Paclitaxel, advance the development of its product candidates, invest in its CMC development for its product candidates and manufacturing infrastructure, and fund working capital and other general corporate purposes.

SVB Leerink, RBC Capital Markets and Evercore ISI are acting as joint book-running managers and Oppenheimer & Co. is acting as lead manager for the offering.

The securities described above are being offered by Athenex pursuant to a shelf registration statement on Form S-3 (File No. 333-227492) that was filed with the Securities and Exchange Commission (the "SEC") on September 24, 2018 and became effective upon filing. The offering will be made only by means of a written prospectus and a prospectus supplement that form a part of the registration statement. A preliminary prospectus supplement relating to and describing the terms of the offering was filed with the SEC and is available on the SEC’s website at www.sec.gov. A final prospectus supplement and the accompanying prospectus relating to this offering will be filed with the SEC and will be available at www.sec.gov. When available, copies of the final prospectus supplement and accompanying prospectus may also be obtained from: SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at 1-800-808-7525, ext. 6218, or by email at [email protected]; RBC Capital Markets, LLC, Attention: Equity Syndicate, 200 Vesey Street, 8th Floor, New York, NY 10281, by telephone at (877) 822-4089, or by email at [email protected]; and Evercore Group L.L.C., Attention: Equity Capital Markets, 55 East 52nd Street, 36th Floor, New York, New York 10055, or by telephone at (888) 474-0200, or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there by any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or jurisdiction.

Chugai and Takeda to Join a Clinical Collaboration for Global Phase III Studies for the Combination Therapy with Multiple Tumor Types in Japan

On September 10, 2020 Chugai Pharmaceutical Co., Ltd. (Chugai, TSE: 4519) and Takeda Pharmaceutical Co., Ltd. (Takeda, TSE:4502/NYSE:TAK) reported that they have decided to study the combination of Tecentriq (atezolizumab), an engineered anti-PD-L1 monoclonal antibody and CABOMETYX (cabozantinib), a tyrosine kinase inhibitor, in Japan (Press release, Chugai, SEP 10, 2020, View Source [SID1234564916]).

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Subsequent to a joint clinical research agreement between Roche and Exelixis and in conjunction with certain rights granted in Japan, Chugai and Takeda will study atezolizumab and cabozantinib combination therapy in Japan. The three global phase III CONTACT studies are ongoing to investigate the combination of atezolizumab and cabozantinib as a potential new treatment option in multiple tumor types, and Chugai and Takeda are planning to join in supporting these studies in Japan.

About Tecentriq
Tecentriq is an immune checkpoint inhibitor targeting PD-L1 which is a protein expressed on tumor cells and tumor-infiltrating immune cells. PD-L1 blocks T-cell activity by binding with PD-1 and B7.1 receptors on T-cell surface. By inhibiting PD-L1, Tecentriq may enable the activation of T-cells and boost immune response against cancer cells.

In Japan, Tecentriq has been approved as a treatment of unresectable advanced/metastatic non-small cell lung cancer, extended-stage small cell lung cancer and PD-L1-positive inoperable or metastatic triple negative breast cancer. In addition, a supplemental application of Tecentriq in combination with Avastin (bevacizumab) was submitted for the treatment of unresectable metastatic hepatocellular carcinoma to the Ministry of Health, Labour and Welfare (MHLW) and was designated as priority review by the MHLW.

About CABOMETYX
In the U.S., CABOMETYX tablets are approved for the treatment of patients with advanced renal cell carcinoma (RCC) and for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib. CABOMETYX tablets have also received regulatory approvals in the European Union and additional countries and regions worldwide. In Japan, the product was approved for the treatment of curatively unresectable or metastatic RCC as CABOMETYX tablets 20mg and 60mg in March 2020 by the Ministry of Health, Labor and Welfare and launched in May 2020. In addition, a supplemental application was submitted in Japan for the treatment of unresectable HCC that has progressed following chemotherapy in January 2020.

Cancer Genetics Announces Participation at the 22nd Annual Rodman & Renshaw Global Investment Conference

On September 10, 2020 Cancer Genetics, Inc. (the "Company") (Nasdaq: CGIX), a leader in drug discovery and preclinical oncology and immuno-oncology services, reported it will present at the 22nd Annual Rodman & Renshaw Global Investment Conference sponsored by H.C. Wainwright & Co., LLC. The conference is being held virtually from September 14-16, 2020 (Press release, Cancer Genetics, SEP 10, 2020, View Source [SID1234564933]).

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Event: 22nd Annual Rodman & Renshaw Global Investment Conference
Date: September 16, 2020
Time: 11:30am ET
Conference Details: www.rodmanevents.com

Cancer Genetics’ management team will provide an overview of the Company’s business and scientific advancements during the live presentation and will be available to participate in one-on-one virtual meetings with investors who are registered to attend the conference. Management will also be available for virtual investor meetings outside the conference.

If you are an institutional investor and would like to attend the Company’s presentation, please click on the following link (www.rodmanevents.com) to register for the Rodman & Renshaw conference. Once your registration is confirmed, you will be prompted to log into the conference website and also be able to request a one-on-one meeting with the Company.

For further information about attending the Company’s presentation or to book an individual appointment with Cancer Genetics’ management, please contact Jennifer K. Zimmons, Ph.D., at +1 917.214.3514 or [email protected].

To see the full list of upcoming events where the Company intends to present or participate, please visit Cancer Genetics’ web site under Events & Presentations.

Akari Therapeutics to Participate in Two September Virtual Investor Conferences

On September 10, 2020 Akari Therapeutics, Plc (Nasdaq: AKTX), a late-stage biopharmaceutical company focused on innovative therapeutics to treat orphan autoimmune and inflammatory diseases where complement (C5) and/or leukotriene (LTB4) systems are implicated, reported that Clive Richardson, Chief Executive Officer, will participate and host investor meetings during the following upcoming virtual investor conferences (Press release, Akari Therapeutics, SEP 10, 2020, View Source [SID1234564952]):

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Event: H.C. Wainwright 22nd Annual Global Investment Conference
Date: Tuesday, September 15, 2020
Presentation: 1:30 p.m. ET
Event: Oppenheimer Fall Healthcare Life Sciences & MedTech Summit
Date: Wednesday, September 23, 2020
Presentation: 10:50 a.m. ET
Investors interested in arranging a virtual meeting with the Company’s management during either conference should contact the respective conference coordinator.

A live webcast and subsequent archived recording of each presentation will be available by visiting ‘Events’ in the Investor Relations section on the Company’s website at www.akaritx.com.

Exicure to Present at Upcoming Conferences

On September 10, 2020 Exicure, Inc. (Nasdaq: XCUR), a pioneer in gene regulatory and immunotherapeutic drugs utilizing spherical nucleic acid (SNA) constructs, reported presentations at the following conferences during the month of September (Press release, Exicure, SEP 10, 2020, View Source [SID1234564969]):

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TIDES: Oligonucleotide & Peptide Therapeutics
Panel discussion: The impact of technological advances in the TIDES Space
Presented by: CEO David Giljohann
Tuesday, September 15, 2020

Panel Discussion: Streamlining the transition from discovery to manufacturing
Presented by: Vice President of Translational Research Weston Daniel
Tuesday, September 15, 2020
H.C. Wainwright 22nd Annual Global Investment Conference
Corporate update
Presented by: CEO David Giljohann
Tuesday, September 15, 2020 at 1:00pm ET
Replays of the H.C. Wainwright webcast will be available on Exicure’s website for 90 days following the webcast.