On September 17, 2020 DAVITA INC. (NYSE: DVA) ("DaVita") a health care provider focused on transforming care delivery to improve quality of life for patients globally and one of the largest providers of kidney care services in the United States, reported the final results of its modified "Dutch auction" tender offer for up to $1.0 billion of its common stock at a price per share not less than $77.00 and not more than $88.00, which expired at 12:00 midnight, New York City time, at the end of the day on September 14, 2020 (Press release, DaVita, SEP 17, 2020, View Source [SID1234565332]).

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Based on the final count by the depositary for the tender offer, a total of 7,981,679 shares of DaVita’s common stock were validly tendered and not validly withdrawn at or below the price of $88.00 per share. DaVita accepted all of these shares for purchase at a purchase price of $88.00 per share, for a total cost of $702,387,752, excluding fees and expenses related to the tender offer. The total of 7,981,679 shares accepted for payment represents approximately 6.5% of DaVita’s total outstanding common stock as of September 16, 2020. The depositary for the tender offer will promptly pay for the shares accepted for purchase pursuant to the tender offer. Payment for shares purchased will be made in cash, without interest, but subject to applicable withholding taxes.

DaVita will finance the share purchases in the tender offer with cash on hand.

The dealer manager for the tender offer was BofA Securities, Inc. Georgeson LLC served as the information agent for the tender offer and Computershare served as the depositary for the tender offer.

On September 17, 2020 Selvita, one of the largest preclinical contract research organizations in Europe, reported that it will present at the 20th Annual Biotech in Europe Forum For Global Partnering & Investment. Instead of hosting an in-person format, the conference will be delivered as a fully digital event that will take place on the 21-24 September (Press release, Selvita, SEP 17, 2020, View Source;utm_medium=rss&utm_campaign=selvita-to-present-at-the-20th-annual-biotech-in-europe-forum-for-global-partnering-investment [SID1234565420]). The main program is being spread throughout four days and will feature high-level speeches and panel discussions. This event draws together public companies with leading investors, analysts, money managers, and pharma licensing executives.

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Edyta Jaworska, Member of the Management Board, Integrated Drug Discovery, is scheduled to present during the panel: Exciting Opportunities in Krakow, Poland – Life Science is Growing Here. The meeting will take place on the 23rd of September at around 4:00 PM CET and will last approximately 30 minutes. The virtual panel will include discussion, a brief presentation by each speaker as well as the Q&A session from the audience.

On September 16, 2020 Tempus, a technology company advancing precision medicine through the practical application of artificial intelligence in healthcare, and LabCorp (NYSE: LH), a leading global life sciences company, reported a collaboration with LabCorp’s drug development business, Covance (Press release, LabCorp, SEP 16, 2020, View Source [SID1234565229]). LabCorp will participate in Tempus’s TIME Trial Network and the companies will work together to accelerate patient enrollment for oncology clinical trials through an innovative, data-driven approach that aims to transform the clinical trial model and modernize how they are designed and executed.

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As novel therapies become increasingly targeted, identifying and enrolling patient populations have become a significant challenge for investigators and sites. Tempus offers a solution with its TIME Trial Program, which uses real-time clinical and molecular data to screen and match patients to biomarker-targeted trials. Institutions participating in The TIME Trial Network are able to initiate their trial on behalf of patients in as few as 10 days.

"The TIME Trial Program has achieved an unparalleled scale thus far, with over 50 provider networks and 2,500 oncologists included in its network," said Kim Blackwell, Chief Medical Officer of Tempus. "We’re excited to collaborate with LabCorp’s drug development business, Covance, and leverage their network of oncology sites and community physicians across the U.S., as well as their successful track record in executing some of the country’s most cutting-edge oncology trials. This collaboration furthers our mission to increase trial participation and ultimately bring the right treatment to the right patients at the right time."

"LabCorp’s drug development business has extensive experience in executing clinical trials and our leadership position in oncology, coupled with Tempus’ innovative clinical trial model, provides thousands of physicians and patients easier access to more therapeutics," said Dr. Paul Kirchgraber, CEO, LabCorp’s drug development business, Covance. "With oncology patient enrollment rates being in the single digits, it’s imperative that we find comprehensive approaches to accelerate oncology clinical trials and bring new treatments to patients faster. The combination of our capabilities will increase the ability to identify patients with specific genetic markers and link them to trial sites, thus greatly expanding access to hard-to-find patient pools for faster enrollment of the right patients for precision medicine oncology clinical trials."

To learn more about the TIME Trial Program, visit www.tempus.com/clinical-trial-matching.

On September 16, 2020 United Therapeutics Corporation (Nasdaq: UTHR) reported that Dr. Martine Rothblatt, Chairman and Chief Executive Officer of United Therapeutics, will provide an overview and update on the company’s business during a fireside chat session at the Oppenheimer Fall Healthcare Life Sciences & MedTech Summit (Press release, United Therapeutics, SEP 16, 2020, View Source;MedTech-Summit/default.aspx [SID1234565246]).

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The presentation will take place on Wednesday, September 23, 2020, from 11:40 a.m. to 12:20 p.m., Eastern Daylight Time, and can be accessed via a live webcast on the United Therapeutics website at View Source An archived, recorded version of the presentation will be available approximately 24 hours after the session ends and can be accessed at the same location for 90 days.

On September 16, 2020 Genelux Corporation, a privately-held biopharmaceutical company, reported that data from the Phase 2 VIRO-15 study evaluating its lead oncolytic virus, Olvi-Vec-primed immunochemotherapy in platinum-resistant/refractory ovarian cancer (PRROC) (NCT02759588), will be presented at the upcoming European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) Virtual Congress 2020, being held September 19-21 (Press release, Genelux, SEP 16, 2020, View Source [SID1234565262]).

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"The Phase 2 data in PRROC patients demonstrated remarkable overall survival in combination with a platinum-based regimen, especially in the difficult-to-treat platinum-refractory disease population, considering these patients were heavily pretreated and largely at pre-hospice stage," said Robert Holloway, MD, principal investigator for VIRO-15 and Chair of Genelux’s Clinical Advisory Board on gynecologic cancers.

"Genelux is pleased with the promising data out of the Phase 2 VIRO-15 study, and we are optimistic about the potential of Olvi-Vec-primed immunochemotherapy to extend the life expectancy and improve the quality of life of patients who currently lack effective treatment options," said Thomas Zindrick, J.D., President and CEO of Genelux. "A registration trial of Olvi-Vec-primed immunochemotherapy is being planned."

Data from the Phase 2 VIRO-15 trial are outlined below.

Abstract Number: 2982

Abstract Title: Phase 2 Trial of Oncolytic Vaccinia Virus Olvi-Vec-Primed Immunochemotherapy in Heavily Treated Platinum-Resistant/Refractory Ovarian Cancer (PRROC)

Abstract Authors: Robert W. Hollowaya, Alberto A. Mendivilb, James E. Kendricka, Lisa N. Abaidb, John V. Brownb, Christine K. Fitzsimmonsa, Jessica A. Kennarda, Monica Kingb, Jane LeBlanca, Katrina Lopezb, Madhavi Manyama, Nathalie D. McKenziea, Kristina M. Morib, Amanda J. Stephensa, Sarfraz Ahmada. aAdventHealth Cancer Institute, Orlando, FL 32804, USA, bGynecologic Oncology Associates, Newport Beach, CA 92663, USA

Session Title/Date: ESMO (Free ESMO Whitepaper) Virtual Congress 2020, Science Weekend, September 19-21, 2020

Abstract Highlights:

Background: Intraperitoneal infusion of Olvi-Vec virus followed by IV carboplatin-doublet (CD) ± bevacizumab (Bev) in heavily pretreated patients with PRROC was evaluated. Primary objectives were RECIST overall response rate (ORR) and progression-free survival (PFS). Secondary objectives included overall survival (OS), CA-125 response, safety and translational studies.

Methods: Patients who progressed on most recent therapies received 2 consecutive days of Olvi-Vec followed by CD ± Bev, and then maintenance single agent ± Bev. Pre- & post-virotherapy tumor biopsies and blood were obtained for analyses.

Key results: 27 patients (median 4 prior lines, 52% platinum-refractory, 48% platinum-resistant) enrolled. Median OS was 15.7 mos (95% CI: 12.3 – 23.5) for all patients. 9/27 (33.3%) patients have survival > 18 months, with 4 of these patients still alive beyond 3-4 years. In patients with platinum-refractory disease, median OS was 15.2 months (95% CI: 10.8 – 33.6).

Conclusions: Despite having PRROC and documented disease progression at enrollment, most patients responded to CD therapies after oncolytic virotherapy, with OS exceeding historical comparisons in heavily pretreated PRROC patients. Virus-induced changes in the tumor microenvironment may explain the apparent reversal of platinum resistance.

About Olvimulogene Nanivacirepvec (Olvi-Vec)
Olvi-Vec is a proprietary, non-pathogenic oncolytic vaccinia virus, modified to increase its safety, tumor selectivity and anti-tumor activity. Virus-mediated oncolysis results in immunogenic cell death and triggers immune activation and memory for long-term immunotherapy against cancer. Clinical results in more than 150 subjects have shown Olvi-Vec is well tolerated with documented clinical benefits.