On June 17, 2020 Kangpu Biopharmaceuticals, a clinical-stage company focused on the discovery and development of next-generation of immunomodulatory small molecules for the treatments of solid tumors, hematological malignancies, auto-immune diseases as well as inflammatory disorders, reported that two posters highlighting preclinical data of the company’s lead drug candidates, KPG-121 and KPG-818, will be presented at the 2020 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting II to be held from June 22-24, 2020 (Press release, Kangpu Biopharmaceuticals, JUN 17, 2020, View Source [SID1234561199]).

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Details of the e-poster presentations on June 22-24 are as follows:

Abstract Title: KPG-121, A Novel Cereblon Modulator, Potently Inhibits Growth of Metastatic Castration Resistant Prostate Cancer in Combination with Androgen Receptor Inhibitors Both In Vitro and In Vivo
Abstract Number: 5300
Poster Number: 5327
Poster Session: Novel Antitumor Agents 2

KPG-121 is a novel modulator of the Cerebron (CRBN) E3 ubiquitin ligase complex CRL4CRBN targeting rapid ubiquitination and degradation of casein kinase 1A1 (CK1α) and transcription factors Aiolos and Ikaros. KPG-121 promotes anti-proliferation and anti-angiogenesis activities and enhances immunomodulatory properties. KPG-121 significantly improves anti-tumor efficacies when combined with androgen-receptor antagonists including Enzalutamide, Abiraterone Acetate, Apalutamide, or Darolutamide in xenograft models when compared to the androgen-receptor antagonist therapy alone. KPG-121 is currently being evaluated in a Phase I study in the US for the treatment of patients with metastatic and non-metastatic castration-resistant prostate cancer in combination with Enzalutamide, Abiraterone Acetate, or Apalutamide (NCT03569280 at www.clinicaltrials.gov).

Abstract Title: KPG-818, A Novel Cereblon Modulator, Inhibits Hematological Malignancies in Preclinical Models
Abstract Number: 5671
Poster Number: 6367
Poster Session: Novel Antitumor Agents 3

KPG-818 represents a novel generation of small molecule modulators of the CRBN E3 ubiquitin ligase complex CRL4CRBN and potently induces the ubiquitination and degradation of Aiolos (IKZF3) and Ikaros (IKZF1), two members of the Ikaros family of zinc-finger transcription factors critical in B-cell development. In preclinical studies, KPG-818 demonstrates outstanding in vitro anti-inflammatory properties and broad spectrum of anti-proliferative activities as well as remarkable in vivo efficacy in animal models of multiple blood cancers. KPG-818 is currently being developed in a Phase I study for the treatment of patients with hematological malignancies in the US (NCT04283097 at www.clinicaltrials.gov).

Abstracts and full session details can be found at www.aacr.org.

On June 17, 2020 Lantern Pharma (NASDAQ: LTRN), a clinical stage biotechnology company focused on leveraging artificial intelligence ("A.I."), machine learning and genomic data to streamline the drug development process and to identify the patients that will benefit from its targeted oncology therapies, reported that it will make two presentations at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) 2020 Virtual Annual Meeting, a meeting of global leaders in cancer research taking place from June 22-24, 2020 (Press release, Lantern Pharma, JUN 17, 2020, View Source;utm_medium=rss&utm_campaign=lantern-pharma-announces-two-presentations-at-american-association-for-cancer-research-aacr-2020-virtual-annual-meeting [SID1234561216]). They represent the Company’s first two presentations since its IPO and subsequent listing on Nasdaq under the ticker symbol ‘LTRN.’

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Each presentation will examine Lantern Pharma’s use of its A.I. platform, RADR (Response Algorithm for Drug Positioning and Rescue), in the development of LP-184, one of three cancer drugs in Lantern Pharma’s pipeline. The first abstract will focus on LP-184’s unique features, including its nanomolar potency and its activity in multi-drug resistant tumors, while the second abstract will highlight Lantern Pharma’s use of machine learning, specifically artificial neural networks, to pinpoint a genomic signature most closely correlated with predicting response to LP-184 across a range of solid tumors and central nervous system (CNS) cancers. This signature is aimed at facilitating treatments using LP-184 through genomics-guided therapy. LP-184 is a drug candidate in preclinical development, which has shown early indications of efficacy in solid tumors, as well as in glioblastoma and CNS cancers with specific genetic and biomarker profiles.

RADR is Lantern Pharma’s proprietary A.I. and machine learning platform, which leverages over 275 million data points across more than 140 drug-tumor interactions to predict the potential response patients will have to Lantern Pharma’s cancer drug candidates and to other drugs that it is reviewing and analyzing. Lantern Pharma continues expanding RADR with additional real-world data points, tumor-specific data sets, proprietary experimental data and validated drug-tumor models. The company is actively developing additional collaborations and partnerships that will help expand RADR both in terms of datasets and functionality.

The AACR (Free AACR Whitepaper) Annual Meeting highlights the work and discoveries of the world’s leading cancer experts and researchers. In response to the COVID-19 pandemic, this year’s meeting will be held virtually and features speakers from leading healthcare institutions, cancer research centers, large pharmaceutical companies and hospitals.

"We know that collaboration and the exchange of ideas among the world’s most renowned oncology experts is key to combatting cancer and improving patient outcomes," said Panna Sharma, CEO of Lantern Pharma. "Each year, the AACR (Free AACR Whitepaper) annual meeting convenes leading voices in cancer treatment from across the globe and is instrumental in advancing cancer research and individual therapies like those Lantern seeks to develop. We very much look forward to presenting our knowledge and methodologies being used to advance LP-184, and to applying the knowledge gained from the conference toward advancing and ultimately commercializing our own pipeline of cancer drugs, realizing long-term value for our shareholders."

POSTER PRESENTATION DETAILS:

Poster One:

"LP-184, a molecule with nanomolar potency, exhibits strong activity in lung cancers with KEAP1 and KRAS mutations," presented by Aditya Kulkarni, Ph.D.
Poster Session Title: Novel Antitumor Agents 1
Abstract # 1464
Poster Number: 4185

Poster Two:

"Machine learning-derived gene signature predicts strong sensitivity of several solid tumors to the alkylating agent LP-184," presented by Umesh Kathad, M.S.
Poster Session Title: Machine Learning
Abstract # 3305
Poster Number: 2090

Full abstracts for the poster presentations can be found at the AACR (Free AACR Whitepaper) annual meeting website, www.aacr.org. They will also be available after the presentations at the Company’s website – www.lanternpharma.com.

On June 17, 2020 The board of directors of AbbVie Inc. (NYSE: ABBV) reported a quarterly cash dividend of $1.18 per share (Press release, AbbVie, JUN 17, 2020, View Source [SID1234561184]).

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The cash dividend is payable August 14, 2020 to stockholders of record at the close of business on July 15, 2020.

Since the company’s inception in 2013, AbbVie has increased its dividend by 195 percent. AbbVie is a member of the S&P Dividend Aristocrats Index, which tracks companies that have annually increased their dividend for at least 25 consecutive years.

On June 17, 2020 Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) reported that Dean Schorno, the company’s chief financial officer, reported that to present a company overview at the BMO 2020 Prescriptions for Success Healthcare Virtual Conference on Tuesday, June 23, 2020 at 10:30 a.m. Eastern Time (Press release, Rigel, JUN 17, 2020, View Source [SID1234561200]).

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To access the live and subsequently archived webcast, go to the Investor Relations section of the company’s website at www.rigel.com. Please connect to Rigel’s website several minutes prior to the start of the live webcast to ensure adequate time for any software download that may be necessary.

On June 17, 2020 Lassen Therapeutics reported it has emerged from stealth and secured $31 million in Series A financing to develop antibodies as potential treatments for fibrosis, rare diseases and oncology (Press release, Lassen Therapeutics, JUN 17, 2020, View Source [SID1234561169]). The Series A financing was led by Frazier Healthcare Partners (Frazier) with participation from Alta Partners and Longwood Fund.

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Founded in 2019, Lassen Therapeutics is developing LASN01, a best-in-class monoclonal antibody targeting IL-11 receptor alpha (IL-11R). IL-11, a member of the IL-6 family of cytokines, is a central mediator of fibrosis and blocking its activity has the potential to be more effective than targeting other factors such as TGF-β and CTGF. IL-11 is also a pivotal effector of tumor microenvironment organization and tumor growth, playing a key role as a mediator between cancer and stromal cells.

Lassen acquired best-in-class human anti-IL-11R monoclonal antibodies from CSL Limited (CSL), a leading global biotechnology company with its R&D facilities headquartered in Melbourne, Australia. Accessing IL-11 research and antibodies from CSL greatly accelerates Lassen’s efforts to bring a novel therapeutic candidate to patients.

Lassen is led by a team of drug developers with deep experience in antibody drug discovery and development. The company was co-founded by industry veterans Mark Barrett, Chief Executive Officer, and David King, Ph.D., who serves as Chief Scientific Officer. The Lassen team has collectively brought more than twenty antibody therapeutics into the clinic with several on the market in the areas of oncology and inflammation – experience it will use to rapidly develop LASN01 and a pipeline of novel antibodies.

"IL-11 is a novel target and blocking the IL-11 pathway represents an exciting therapeutic approach for both fibrosis and oncology," said Mr. Barrett. "Inhibition of this previously unexplored pathway has the potential to make a major impact on the course of a number of fibrotic diseases. Targeting IL-11 may also present a strategy to inhibit tumor proliferation and alter the structure of the tumor microenvironment to allow more effective cancer therapies."

Under the agreement, Dr Andrew Nash, Senior Vice President, Research at CSL will join Lassen’s scientific advisory board. "We are pleased that Lassen will continue the development of CSL’s anti-IL-11R monoclonal antibody program," said Dr. Nash. "We hope it will lead to better treatment options for oncology and fibrosis patients."

Lassen has also announced a partnership with FUJIFILM Diosynth Biotechnologies (FDB) to accelerate its anti-IL-11R program. FDB has extensive industry leadership in cell culture processes including monoclonal antibody development and manufacturing. The LASN01 program is leveraging FDB’s high throughput cell culture platform which is based on advanced, single-use technologies to streamline and accelerate production of high-quality drug substance for clinical trials. "Working with leading companies such as CSL, Ltd and FUJIFILM Diosynth Biotechnologies has enabled us to rapidly advance our development programs and best-in-class novel therapies towards clinical evaluation," said Dr. King.

Lassen was formed as part of Frazier’s company creation efforts. Frazier’s Life Sciences team builds companies developing and commercializing novel therapeutics and has started or seeded more than twenty companies since 2005. Frazier leverages its extensive relationships with pharmaceutical companies and academic institutions to identify and license assets into focused new companies with exceptional management teams.