On March 19, 2025 Niagen Bioscience, Inc. (Nasdaq: NAGE) (formerly ChromaDex Corp.), the global authority on NAD+ (nicotinamide adenine dinucleotide) with a focus on the science of healthy aging, reported it has changed its corporate name to Niagen Bioscience, Inc. ("Niagen Bioscience" or the "Company") and the Company’s common stock will begin trading under the new Nasdaq symbol "NAGE" at stock market open today, Wednesday, March 19, 2025 (Press release, ChromaDex, MAR 19, 2025, View Source [SID1234651885]). The CUSIP number for the Company’s common stock will remain the same.

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ChromaDex Evolves into Niagen Bioscience, Marking a New Era of Uncovering the Potential of NAD+ with Precision Science

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With a legacy spanning over 25 years, this strategic evolution underscores the Company’s true identity as the pioneer of NAD+ research and innovator behind transformative NAD-boosting healthy-aging solutions. At the forefront is Niagen Bioscience’s clinically proven, patented flagship nicotinamide riboside (NR) ingredient, Niagen – the most well-researched, efficient, and high-quality, and legal NAD+ booster available.

"This is more than a name change; this is a turning point in our story," said Rob Fried, CEO of Niagen Bioscience. "We have achieved several scientific, financial, and strategic milestones. As Niagen Bioscience, the global leader in NAD+ science and commerce, we have the opportunity to help every living being around the world age better."

Building on a 25+ year legacy, Niagen Bioscience’s renewed mission is simple yet powerful: "There’s a better way to age." The Company remains dedicated to addressing one of life’s most complex challenges—aging. Embodying precision science, Niagen Bioscience is distinguished by state-of-the-art laboratories, rigorous scientific and quality protocols, and independent research collaborations with renowned investigators and institutions worldwide.

Niagen Bioscience’s clinically proven product portfolio, Tru Niagen and Niagen Plus, is the pinnacle of NAD+ supplementation. Tru Niagen, the Company’s consumer supplement featuring clinically proven food-grade Niagen (patented NR), is the number one NAD+ boosting oral supplement in the United States†. Niagen Plus features pharmaceutical-grade Niagen (NR), compounded by U.S. FDA-registered 503B outsourcing facilities. It is available by prescription as intravenous (IV) and injectable Niagen. Niagen Bioscience is the first company in the U.S. to offer a novel branded ingredient (Niagen) both as a direct-to-consumer dietary supplement (Tru Niagen) and as an intravenous and injectable pharmaceutical-grade product (Niagen IV).

"Our new identity creates a stronger foundation for expanding scientific discoveries and opens doors for potential future strategic partnerships across the bioscience and healthcare sectors," added Mr. Fried. "With this name change, we are celebrating that Niagen is a household name synonymous with healthy aging."

Niagen Bioscience recently reported its fourth quarter and full-year 2024 financial results, with strong full-year net sales at $99.6 million, up 19% from the prior year, and $44.7 million in cash and no debt position. Niagen Bioscience continues to lead the NAD+ space and is reinforced by strong financial results, Tru Niagen’s position as the number one NAD+ boosting supplement in the United States†, the onboarding of Niagen IV at 475 clinics nationwide, and the Company’s distinctive external research program, which has generated over 35 human clinical studies on Niagen.

To mark this milestone today, the Niagen Bioscience executive team will participate in the Nasdaq Closing Bell Ceremony on March 19, 2025, the same day as the official announcement. A live-stream of the Nasdaq Closing Bell Ceremony will take place at www.nasdaq.com at 3:50 pm ET / 12:50 pm PT. This event symbolizes the Company’s next chapter as the pioneer of NAD+ and healthy-aging science.

To learn more about Niagen Bioscience’s bold new chapter, visit www.niagenbioscience.com. Follow the Company’s news, research milestones, and announcements on social media here View Source

On March 19, 2025 Circio Holding ASA (OSE: CRNA), a biotechnology company developing powerful circular RNA technology for next generation nucleic acid medicine, reported a live webcast at 10:00am CET on Wednesday 26 March 2025 (Press release, Circio, MAR 19, 2025, View Source [SID1234651254]). In the webcast, Circio management will provide a corporate update and present the latest developments for the circVec platform technology.

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The webcast will include an overview of ongoing testing with the novel circVec 3.0 generation, AAV and non-viral gene therapy vector development, and tissue-specific circVec expression data in vivo, as well as an outlook on experimental plans and milestones.

The corporate section will cover Circio´s 2024 financial results (unaudited) and provide an update on financing and business development activities for 2025.

Presenters:
CEO Dr. Erik Digman Wiklund
CFO Dr. Lubor Gaal

Time: 10:00 CET on 26 March 2025

click here to access the Teams webcast
Meeting ID: 392 868 593 190
Passcode: Mn7uS2qQ

Participate by phone:
+47 21402155
Phone conference ID: 394 288 903#

Questions can be submitted in advance by email to Erik D Wiklund: [email protected] or directly in the live webcast.

On March 19, 2025 Jacobio Pharma (1167.HK) reported its 2024 annual results, with revenue of RMB160 million, R&D expense of RMB330 million (Press release, Jacobio Pharmaceuticals, MAR 19, 2025, View Source [SID1234651271]). Major operating and financing activities generated RMB320 million cash inflows. By the end of 2024, cash and bank balances and bank credit balances amounted to RMB1.45 billion. Jacobio also announced recent business progress and expected milestones.

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"2024 is a transforatmive year for Jacobio. We have submitted a New Drug Application (NDA) for the KRAS G12C inhibitor glecirasib and have licensed out the China rights of glecirasib and the SHP2 inhibitor sitneprotafib to our partner. This marks Jacobio’s successful transformation from the early R&D stage to an innovation-driven value realization stage," said Dr.Yinxiang Wang, the Chairman and CEO of Jacobio Pharma. "Looking ahead to 2025, glecirasib is expected to receive the official approval for marking, which will continuously generate cash flow to invest in Jacobio’ subsequent pipeline."

Development of core clinical stage products

Glecirasib (JAB-21822, KRAS G12C inhibitor) and sitneprotafib (JAB-3312, SHP2 inhibitor)

The commercialization and further clinical development in China of glecirasib and sitneprotafib were licensed to Allist on August 30, 2024.
Non-small cell lung cancer (NSCLC)
The NDA application of glecirasib monotherapy in second-line and above NSCLC was submitted to the CDE (China Drug Evaluation Center) in May 2024 and the priority review designation was granted in the same month. Glecirasib is expected to be approved in the first half of 2025.
The Phase III pivotal trial of glecirasib combined with sitneprotafib in front-line NSCLC enrolled the first patient in China on August 7, 2024.
Multi-tumor basket
The multi-tumor basket registration phase II trial of glecirasib for the treatment of pancreatic cancer, biliary tract cancer, gastric cancer, small bowel cancer, appendiceal cancer and other indications has been initiated in China. Glecirasib has received orphan drug designation (ODD) from FDA and EMA for pancreatic cancer.
Colorectal cancer
The Phase III trial of glecirasib mono or in combination with cetuximab in third line was approved by the CDE in May 2024
JAB-23E73 (pan-KRAS inhibitor)

The IND (Investigational New Drug) applications were approved in China and the United States in September 2024
The first patient was enrolled in November 2024
The dose escalation phase is expected to be completed in the second half of 2025
JAB-30355 (p53 Y220C activator)

The IND application of FIH (first-in-human) global trial of JAB-30355 was approved by the FDA in March 2024 and by the CDE in June 2024.
The first patient was enrolled in July 2024
The dose escalation is expected to be completed in the second half of 2025
JAB-8263 (BET inhibitor)

The dose escalation for JAB-8263 in solid tumors and hematologic malignancy were completed in the U.S. and China, respectively. The RP2D (phase II recommended doses) was obtained.
Dose expansion in patients with myelofibrosis is ongoing.
Solid tumor portion with specific biomarkers is being explored. .
JAB-2485 (Aurora A inhibitor)

A Phase I/IIa global trial of JAB-2485 is ongoing in the U.S. and China.
Dose escalation phase is expected to be completed in the first half of 2025
The expansion of monotherapy and combination with chemotherapy are being planned.
Development of pre-clinical pipelines

JAB-BX467 (HER2-STING iADC)

Clinical candidate of HER2-STING iADC has been nominated in the second half of 2024.
The IND application is being planned to be submitted in 2026.
JAB-BX600 (KRAS G12D ADC)

The clinical candidate is expected to be nominated in the second half of 2025.
As of December 31, 2024, Jacobio has filed more than 360 patent applications worldwide, including 126 authorized patents.

Conference call information

Jacobio Pharma will hold a conference call at 9:30 AM (Beijing time) on March 20, 2024. Participants, please register in advance through this link: View Source

On March 19, 2025 Imugene Limited (ASX:IMU), a clinical-stage immuno-oncology company, reported that the US Food and Drug Administration (FDA) has granted Fast Track Designation to its allogeneic CAR T-cell therapy, azer-cel (azercabtagene zapreleucel), for the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL) (Press release, Imugene, MAR 19, 2025, https://mcusercontent.com/e38c43331936a9627acb6427c/files/016deafa-b80d-5bf6-262c-0e50c1d6128c/Azer_cel_Granted_FDA_Fast_Track_Designation_in_Blood_Cancer.pdf [SID1234651235]).

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The FDA’s Fast Track Designation is designed to facilitate the development and expedite the review of drugs that address serious or life-threatening conditions and meet an unmet medical need. Benefits of this designation include more frequent meetings with the FDA to discuss development plans, the option for rolling review of regulatory submissions, and potential eligibility for Accelerated Approval and Priority Review upon meeting relevant criteria.

Azer-cel is an off-the-shelf, CD19-directed CAR T-cell therapy engineered to overcome the logistical challenges of autologous CAR T therapies, such as prolonged manufacturing times and limited patient access. By leveraging pre-manufactured donor T-cells, azer-cel allows for rapid treatment delivery. Clinical data from the ongoing Phase 1b trial has demonstrated significant promise to date, particularly in patients who failed multiple prior therapies including autologous CAR T.

The therapy incorporates a novel combination of lymphodepletion chemotherapy and interleukin-2 (IL-2) to enhance CAR T persistence and efficacy. Azer-cel has shown a manageable safety profile, with no instances of immune effector cell-associated neurotoxicity syndrome (ICANS) observed in key patient cohorts.

Leslie Chong, Managing Director and CEO of Imugene, commented: "Receiving FDA Fast Track Designation is a testament to the transformative potential of azer-cel for patients battling relapsed or refractory DLBCL. We are committed to working closely with the FDA to bring this important therapy to patients as efficiently as possible."

DLBCL is the most common and aggressive form of non-Hodgkin’s lymphoma, with a significant portion of patients experiencing relapse or resistance to standard treatments. Azer-cel addresses this critical unmet need by offering a novel therapeutic approach for this challenging blood cancer.

On March 19, 2025 Genenta Science (Nasdaq: GNTA), a pioneer in immuno-oncology and a leader in cell-based therapeutics, reported a €20 million ($21.9 million) financing through the issuance of a Mandatory Convertible Bond to ENEA Tech and Biomedical (ETB) to support the expansion of its pipeline by advancing Temferon in metastatic Renal Cell Cancer (mRCC) (Press release, Genenta Science, MAR 19, 2025, View Source [SID1234651255]). ETB is a leading private foundation, supervised by the Italian Ministry of Enterprises and Made in Italy, managing over €1,7 billion in assets under management through two funds. With deep expertise in the biomedical sector, ETB is an established authority in identifying and supporting high-potential biotech companies.

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"ETB conducted a deep and thorough scientific and legal due diligence before committing to this investment. We spent several months in negotiations," said Pierluigi Paracchi, CEO of Genenta. "We believe the mandatory convertible bond terms are indicative of the potential long-term value of Genenta’s shares. The bond will not result in immediate dilution to Genenta’s shareholders, and is expected to provide the necessary capital to achieve key milestones in the Company’s new mRCC trial. Conversion to equity is set for March 2028, followed by a two-year lock-up period. Naturally, the process will be accelerated in the event of a change of control of our Company. ETB is a trusted partner with strong financial backing, which will help ensure the financial stability required to advance the validation of the Temferon platform and our ability to pursue strategic collaborations."

The February data cutoff from the Phase 1/2a Glioblastoma Multiforme (GBM) uMGMT trial shows an increase in the percentage of patients surviving at two years, now reaching 29%, compared to 25% in October. Additionally, there is a marginal improvement in median overall survival, which now stands at 17 months. Historically reported data showed the overall survival of uMGMT patients undergoing standard of care to be approximately 14% at two years with a median overall survival of 13–15 months.

Notably, the Phase 1/2a trial in metastatic Renal Cell Carcinoma has recently begun enrolling patients, further strengthening the Company’s clinical pipeline for Temferon.

Prof. Luigi Naldini, Co-founder of Genenta, added: "We are continuing to demonstrate at pre-clinical and clinical levels Temferon’s ability to reprogram the tumor microenvironment, which in turn induces cell-mediated immune responses, as suggested by Genenta’s ongoing GBM trial and which will be under testing in the Company’s mRCC trial."

ETB Mandatory Convertible Bond Investment Terms:

Total Bond: €20 million ($21.9M), subscribed by ETB;
Maturity: three years, with mandatory conversion at maturity (March 2028);
Lock-up: two years following conversion (March 2030);
Funding Structure:
First Tranche: €7.5 million ($8.2M), which is expected to provide sufficient funding to assess safety in the ongoing Phase 1/2a trial for mRCC.
Second Tranche: €12.5 million ($13.7M), conditional upon achieving safety and tolerability in the ongoing Phase 1/2a trial for mRCC, among other conditions.
ETB equity in Genenta will be capped at 29%.
The maximum conversion price is $17.64 per share based on an Independent Evaluation conducted by ETB’s Advisor on Genenta.