On December 30, 2025 XOMA Royalty Corporation (NASDAQ: XOMA), the biotech royalty aggregator, reported it has amended its collaboration, originally established in 2006, with Takeda through a strategic royalty share transaction. Takeda’s royalty and milestone payment obligations to XOMA Royalty related to mezagitamab will be reduced, and XOMA Royalty will receive payments based on low to mid-single-digit royalties and milestones across a basket of nine development-stage assets that are held within Takeda’s externalized assets portfolio.

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"We continue to find ways to expand and diversify our royalty and milestone portfolio through creative transactions that are beneficial to both parties," stated Brad Sitko, Chief Investment Officer of XOMA Royalty. "Takeda and XOMA Royalty have a long history of collaboration. By amending our collaboration, we are able to return a portion of our mezagitamab economics to Takeda, while also expanding and diversifying XOMA Royalty’s portfolio across several interesting early- and late-stage programs."

Mezagitamab
Prior to amending the collaboration, XOMA Royalty held a mid-single digit royalty and $16.25 million in potential milestones associated with mezagitamab. Going forward, XOMA Royalty will retain a low single-digit royalty entitlement on mezagitamab and up to $13.0 million in milestones.

Development-Stage Assets from Takeda’s Externalized Assets Portfolio

Osavampator

Neurocrine Biosciences is developing osavampator, a potential first-in-class, investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) positive allosteric modulator (PAM) for patients who have inadequate response to treatment for major depressive disorder (MDD).
Volixibat

Mirum Pharmaceuticals is developing volixibat, a minimally absorbed, orally administered investigational therapy designed to selectively inhibit ileal bile acid transporter (IBAT), for primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC).
OHB-607 and five early-stage Oak Hill Bio assets

Oak Hill Bio and their partner are developing OHB-607, a recombinant human IGF-1/IGFBP-3 for the prevention of bronchopulmonary dysplasia in premature infants. Additional Oak Hill Bio assets that have the potential to generate royalties address other high unmet need or rare disease areas.
REC-4881

Recursion Pharmaceuticals is developing REC-4881, an investigational MEK1/2 inhibitor for familial adenomatous polyposis, a rare tumor predisposition syndrome affecting approximately 50,000 people in the U.S., France, Germany, Italy, Spain, and the UK.

(Press release, Xoma, DEC 30, 2025, View Source [SID1234661659])

On December 30, 2025 XOMA Royalty Corporation (NASDAQ: XOMA), the biotech royalty aggregator, reported it has amended its collaboration, originally established in 2006, with Takeda through a strategic royalty share transaction. Takeda’s royalty and milestone payment obligations to XOMA Royalty related to mezagitamab will be reduced, and XOMA Royalty will receive payments based on low to mid-single-digit royalties and milestones across a basket of nine development-stage assets that are held within Takeda’s externalized assets portfolio.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"We continue to find ways to expand and diversify our royalty and milestone portfolio through creative transactions that are beneficial to both parties," stated Brad Sitko, Chief Investment Officer of XOMA Royalty. "Takeda and XOMA Royalty have a long history of collaboration. By amending our collaboration, we are able to return a portion of our mezagitamab economics to Takeda, while also expanding and diversifying XOMA Royalty’s portfolio across several interesting early- and late-stage programs."

Mezagitamab
Prior to amending the collaboration, XOMA Royalty held a mid-single digit royalty and $16.25 million in potential milestones associated with mezagitamab. Going forward, XOMA Royalty will retain a low single-digit royalty entitlement on mezagitamab and up to $13.0 million in milestones.

Development-Stage Assets from Takeda’s Externalized Assets Portfolio

Osavampator

Neurocrine Biosciences is developing osavampator, a potential first-in-class, investigational alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) positive allosteric modulator (PAM) for patients who have inadequate response to treatment for major depressive disorder (MDD).
Volixibat

Mirum Pharmaceuticals is developing volixibat, a minimally absorbed, orally administered investigational therapy designed to selectively inhibit ileal bile acid transporter (IBAT), for primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC).
OHB-607 and five early-stage Oak Hill Bio assets

Oak Hill Bio and their partner are developing OHB-607, a recombinant human IGF-1/IGFBP-3 for the prevention of bronchopulmonary dysplasia in premature infants. Additional Oak Hill Bio assets that have the potential to generate royalties address other high unmet need or rare disease areas.
REC-4881

Recursion Pharmaceuticals is developing REC-4881, an investigational MEK1/2 inhibitor for familial adenomatous polyposis, a rare tumor predisposition syndrome affecting approximately 50,000 people in the U.S., France, Germany, Italy, Spain, and the UK.

(Press release, Xoma, DEC 30, 2025, View Source [SID1234661659])

On December 30, 2025 Insilico Medicine (03696.HK), a global leader in AI-driven drug discovery and a portfolio company of Qiming Venture Partners, reported successfull listing on the Hong Kong Stock Exchange (HKEX). The listing marks the largest biotech IPO on the Hong Kong stock market in 2025. With an issue price of HK$ 24.05 per share, Insilico Medicine opened at HK$35.00 per share, representing a market capitalization of approximately HK$ 19.51 billion.

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Qiming Venture Partners is one of Insilico Medicine’s most important institutional investors. Qiming Venture Partners led the Company’s Series B financing round in 2019 and continued its support in subsequent Series C and D rounds, with an about 7 percent stake in Insilico Medicine before its IPO.

Founded in 2014, Insilico Medicine employs a business model based on the Pharma.AI platform, focuses on internal drug research and development through artificial intelligence. It has gradually expanded the application of Pharma. AI to more industries such as advanced materials, agriculture, nutritional products, and veterinary drugs. It has now efficiently built a pipeline portfolio covering over 30 innovative projects in a wide range of fields with extensive demands, such as oncology, immunology, fibrosis, and metabolism, and owns the world’s most advanced first-in-class AI-based drugs.

To date, 13 of the world’s top 20 pharmaceutical companies by revenue have entered into software platform collaborations with Insilico Medicine. Insilico Medicine has also reached licensing agreements on three pipelines with global drugmakers such as Exelixis and Menarini, bringing a potential revenue of USD2 billion for the company. The Company has also established drug R&D partnerships with other internationally renowned pharmaceutical firms including Sanofi, Lilly, and Shanghai Fosun Pharmaceutical (Group) Co., Ltd.

"Insilico is dedicated to extending human productive longevity and this listing provides us with more resources to advance our mission. Over the past few years, we set very clear industry benchmarks demonstrating that AI can help make drug discovery faster, cheaper, and deliver higher success rates in preclinical and early clinical development. We have validated the end-to-end capabilities of AI-empowered programs from novel target discovery to molecular generation, and then to preclinical and clinical stages. Going forward, we will continue to increase investment in our AI platform and innovative pipeline, accelerate the advancement of differentiated innovative programs into clinic, and bring truly accessible, affordable, and breakthrough treatment solutions to patients worldwide." said Alex Zhavoronkov, PhD, Founder and CEO, Chief Business Officer of Insilico Medicine.

"We invest in Insilico Medicine based on a simple belief that ‘AI will profoundly change the pathway and efficiency of drug development.’ We decided to invest in Insilico Medicine in 2019 because of its research in frontier areas when generative AI was not yet popularized. Now the value of Insilico Medicine in the field of AI pharmaceuticals is gradually being realized through preclinical validation and pipeline licensing. We expect AI to not only empower early-stage research and development but also effectively accelerate the clinical stage process in the future to enable new drugs to benefit patients earlier," Dr. Chen Kan, Partner and Healthcare Co-Lead at Qiming Venture Partners, said.

(Press release, Insilico Medicine, DEC 30, 2025, View Source [SID1234661660])

On December 29, 2025 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, reported that members of its management team will present at the 44th Annual J.P. Morgan Healthcare Conference on Monday, January 12, 2026 at 8:15 a.m. Pacific Time.

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Interested parties may access a live webcast of the fireside chat on the "Investors" section of the company’s website at: View Source The webcast will be archived and available for replay for at least 30 days after the event.

(Press release, 10x Genomics, DEC 29, 2025, View Source [SID1234661646])

On December 29, 2025 Oncodesign Precision Medicine (OPM) (ISIN: FR001400CM63; Mnemonic: ALOPM), a biopharmaceutical company specializing in precision medicine for the treatment of resistant and metastatic cancers, and Navigo Proteins GmbH (Halle, Germany), a biopharmaceutical company specializing in the discovery and development of new precision medicine approaches based on the Affilin technology platform, reported the termination of their collaboration agreement signed in May 2024.

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Based on both parties’ commitment to scientific excellence and resource optimization, OPM and Navigo have mutually agreed to end this specific collaboration. As a reminder, the partnership between Navigo and OPM was intended to pool their tumor targeting and identification technologies to discover and develop new radiotheranostic agents that are more precise and effective against resistant and metastatic cancers.

The end of this partnership follows a standard prioritization process inherent in advanced research programs. OPM is actively pursuing its innovation strategy in precision medicine and continues to develop its portfolio of assets through its three technology platforms:

Nanocyclix, dedicated to the design and selection of next-generation kinase inhibitors;
OncoSNIPER, for the selection of therapeutic targets using artificial intelligence;
PROMETHE, to design and select radiolabeled biological molecules for systemic radiotherapy.
The COMETE program (moleCular radiOtherapy for METastatic Colorectal and gastric cancErs), which aims to develop a portfolio of radiotheranostic molecules for the treatment of advanced digestive cancers, is continuing. This project, led by OPM, the cancer center (CGFL), and the Institute of Molecular Chemistry at the University of Burgundy (ICMUB, UMR CNRS 6302), all based in Dijon, aims to develop a radiotheranostic candidate through preclinical dosimetry studies. OPM will evaluate other promising vectorization technologies and new target selection work is progressing.

Navigo Proteins will continue the initiated program based on its Affilin and HEAD platform technologies as well as AI assisted de-novo protein design addressing gastric cancers with a strong focus on an accelerated pathway into early testing in human patients.

Philippe Genne, CEO of Oncodesign Precision Medicine, said: "We would like to warmly thank the Navigo team for the quality of the work accomplished. This collaboration has enabled us to explore relevant Affilin leads, even if our collaboration has not demonstrated the expected potential within the program timelines due to the challenges encountered with the first targets selected. Our relationship remains excellent and we continue to move forward with determination on our key programs, including COMETE, a major strategic initiative for OPM."

Henning Afflerbach, CEO of Navigo Proteins GmbH, added: "We have enjoyed working with OPM and maintain a strong mutual appreciation for their core expertise. While further strengthening our commitment to develop innovative radiotheranostics from discovery into the clinic for the benefit of human patients, we wish our partner OPM all the best for the future and remain open to discussions when new opportunities arise."

(Press release, Oncodesign, DEC 29, 2025, View Source [SID1234661647])