On February 19, 2020 Genprex, Inc. ("Genprex" or the "Company") (Nasdaq: GNPX), a clinical stage gene therapy company developing a new and potentially life-saving approach to treating some of the world’s most deadly cancers based upon a novel proprietary technology platform, reported it has entered into securities purchase agreements with institutional investors for the purchase and sale of 5,000,000 shares of common stock, par value $0.001 per share, at an offering price of $3.50 per share, pursuant to a registered direct offering, priced at-the-market under Nasdaq rules (Press release, Genprex, FEB 19, 2020, View Source [SID1234554501]). There are no warrants in the offering. The gross proceeds of the offering will be approximately $17,500,000 before deducting fees and other estimated offering expenses. The Company intends to use the net proceeds to advance its lead clinical programs in non-small cell lung cancer (NSCLC) and for working capital and general corporate purposes. The closing of the registered direct offering is expected to take place on or about February 21, 2020, subject to the satisfaction of customary closing conditions.

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A.G.P./Alliance Global Partners is acting as lead placement agent for the offering.

Joseph Gunnar & Co., LLC is acting as co-placement agent for the offering.This offering was made pursuant to an effective shelf registration statement on Form S-3 (File No. 333-233774) previously filed with the U.S. Securities and Exchange Commission (the "SEC") and an additional registration statement on Form S-3 filed pursuant to Rule 462(b) under the Securities Act 1933, as amended, filed with the SEC. This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. A prospectus supplement relating to the shares of common stock will be filed by Genprex with the SEC. When available, copies of the prospectus supplement, together with the accompanying prospectus, can be obtained at the SEC’s website at www.sec.gov or from A.G.P./Alliance Global Partners, 590 Madison Avenue, 36th Floor, New York, New York 10022 or by email at [email protected]. Joseph Gunnar & Co. LLC, 30 Broad Street, 11th Floor, New York, New York 10004 or by email at [email protected].

On February 19, 2020 Tmunity Therapeutics, Inc., a private clinical-stage biotherapeutics company focused on saving and improving lives by delivering the full potential of next-generation T-cell immunotherapy, reported that management is scheduled to present at two upcoming investor conferences (Press release, Tmunity Therapeutics, FEB 19, 2020, View Source [SID1234554517]).

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Cowen 40th Annual Health Care Conference
Monday, March 2, 2020
1:30 PM ET
Boston, MA

Oppenheimer 30th Annual Healthcare Conference
Wednesday, March 18, 2020
2:45 PM ET
New York, NY

On February 19, 2020 NeoTX Therapeutics, a clinical-stage biotechnology company leveraging its proprietary Selective T cell Redirection (STR) platform to develop targeted anticancer immunotherapies, reported that it has closed a $45 million Series C financing. In conjunction with the financing, former vice chairman of The Blackstone Group, J. Tomilson Hill, Chairman of NDFOS Co., Ltd, Andrew Kim, Paul T. Marinelli and Nobel laureate Dr. Roger Kornberg, the chief scientific officer of NeoTX have joined the NeoTX Board of Directors. To date, NeoTX has raised over $60 million (Press release, NeoTX, FEB 19, 2020, View Source [SID1234554482]). NeoTX plans to use the Series C proceeds to advance its STR platform for the treatment of advanced and metastatic solid tumors as well as to in-license new technologies.

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"With the funds raised in this financing, we intend to complete the dose escalation phase of the Phase 1b trial of naptumomab estafenatox ("Nap") in combination with durvalumab and continue to develop our patented STR platform," said Asher Nathan, chief executive officer of NeoTX. "Our platform, which uniquely leverages the body’s natural antibacterial immune response to selectively redirect T cells to kill the tumor, has the potential to be applicable in a variety of solid tumor indications and in combination with other immunotherapies. We look forward to the clinical advancement of Nap and expanding our platform in order to provide new options to patients suffering from advanced cancers."

The open-label, multicenter, dose-finding Phase 1b study of Nap (NCT03983954) is currently enrolling. Patients are dosed with a combination of Nap and AstraZeneca’s (NYSE: AZN) checkpoint inhibitor IMFINZI (durvalumab). NeoTX aims to establish the maximum tolerated dose before advancing to a larger cohort expansion phase in the Unites States.

On February 19, 2020 H3 Biomedicine, Inc. (H3), a U.S.-based precision medicine research & development subsidiary of Eisai Co., Ltd., reported the appointment of Antonio Gualberto, MD, PhD, to the position of Chief Medical Officer (CMO) (Press release, H3 Biomedicine, FEB 19, 2020, View Source [SID1234554502]). Dr. Gualberto will oversee global clinical research & development for the H3 pipeline of clinical stage assets.

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"H3 is at a pivotal stage of growth. The breadth of our precision medicine-driven discovery and clinical R&D require a CMO with vast scientific knowledge and leadership expertise," said Lihua Yu, PhD, President and Chief Data Science Officer, H3. "Dr. Gualberto, possesses more than 20 years of experience in developing clinical assets at multiple biopharma companies, his deep acumen and proven success will be instrumental as we work toward our goal of delivering clinically meaningful outcomes for patients with highly unmet medical needs."

Most recently Dr. Gualberto served as co-founder and CMO at Kura Oncology, a clinical-stage biopharmaceutical company focused on the development of precision medicines for the treatment of cancer. At Kura, Dr. Gualberto led the discovery of the mechanism of action and clinical proof-of-concept of farnesyl transferase inhibitors as well as bringing a pipeline of new agents to the clinic. Prior to Kura, Dr. Gualberto held positions of increasing responsibility at EMD Serono, a subsidiary of Merck KGaA, Takeda and Pfizer. Dr. Gualberto received his MD and PhD degrees from the University of Seville in Spain. He also completed several fellowships in the field of Molecular Pathology, was a member of the Berkeley National Laboratory, and held academic faculty positions at Case Western Reserve University and Brown University.

"Our entire organization is thrilled by the appointment of Dr. Gualberto to the position of CMO here at H3," commented Terushige Iike, Chief Executive Officer of H3 and President of the Oncology Business Group at Eisai Co., Ltd. "We eagerly anticipate the progress we will make as a company with Antonio leading our global clinical research & development organization. His expertise and wide experience will be invaluable to H3 as we advance our pipeline of multiple clinical stage assets."

"With the umbrella of support of a global pharmaceutical company such as Eisai, H3 is uniquely positioned as a clinical stage biopharmaceutical company. In creating a prolific drug discovery engine and partnership platform, H3 has shown itself to be a leader in the development of new clinical programs," said Dr. Gualberto. "H3 has a first-rate team that is highly regarded in the Oncology community, with fantastic discovery and development capabilities and I look forward to working closely with our entire organization."

On February 19, 2020 Premier Inc. (NASDAQ: PINC), through its ProvideGx program, reported that it has partnered with Pfizer Inc. to supply Corvert (ibutilide fumarate injection) and Vincristine Sulfate Injection, USP, to healthcare providers, to help stabilize the long-term supply of two vital medications for its members (Press release, Premier, FEB 19, 2020, View Source [SID1234554518]).

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Corvert is an anti-arrhythmic heart medication used to treat atrial fibrillation or atrial flutter. Vincristine is a chemotherapy drug, primarily used to treat childhood cancers such as acute leukemia, and, in combination with other oncolytic agents, Hodgkin’s and non- Hodgkin’s lymphoma, rhabdomyosarcoma, neuroblastoma and Wilms’ tumor.

"Supporting a sustainable supply of these important medicines is a top priority for Premier and our members," said Premier’s President, Michael J. Alkire. "This agreement speaks to the core strengths of the ProvideGx program – our ability to provide both short- and long-term solutions to support our members and patients. Together with our members, we have the nimbleness to act quickly when market events require it, thereby improving access and raising the bar for the entire drug supply chain. Moreover, the goal of ProvideGx is to create market stability and give manufacturers assurances to make the necessary investments for a consistent, long-term supply."

Premier’s ProvideGx program identifies safe, high-quality supply sources for drugs that are or may be at risk of being added to the national drug shortage list. Guided by health systems with more than 1,600 hospitals across the nation, Premier’s ProvideGx program has provided members access to more than 150 drugs that are or have been recently designated as shortage drugs, including metoprolol; cysteine hydrochloride; sodium bicarbonate; diphenhydramine; hydromorphone; lidocaine; morphine; thiamine; phytonadione injection; and emergency, pre-filled syringes of calcium chloride, epinephrine, sodium bicarbonate, atropine sulfate, dextrose and lidocaine. The program plans to introduce additional drugs from a target list of more than 50 products in months to come.

"Patients need continued access to these critical drugs and important treatments, "said Jerry Storm, Senior Vice President of Pharmacy Services at OSF HealthCare of Peoria, IL. "We commend Premier and Pfizer for reaching this deal to support long-term access to these medications now so that we can go back to the business of providing care to our patients that results in outstanding outcomes. Having a reliable supply of these drugs is critical for patients who can’t afford to wait, and crucial for their survival."

ProvideGx is part of Premier’s ongoing effort to help facilitate the availability of high-quality products, including drugs for which there may be supply challenges. In doing so, Premier is working to insulate its members from supply fluctuations that may affect the market at large.

"Over the past several years, Pfizer has made significant advancements in addressing drug shortages, including investing $2 billion to modernize manufacturing and increase capacity," said Suneet Varma, Global President, Pfizer Hospital. "This agreement with Premier continues to build on these efforts — which we hope will ultimately increase patient access to two vital medicines, Corvert and Vincristine — helping to drive market sustainably in the long term."