Immunis.AI to Present at the BIO CEO & Investor Conference

On February 6, 2020 Immunis.AI, a privately held immunogenomics company with a patented liquid biopsy platform, reported that its President and Chief Executive Officer, Mark McDonough, will present at the BIO CEO & Investor Conference being held in New York City from February 10-11, 2020 (Press release, ImmunisAI, FEB 6, 2020, View Source [SID1234553955]).

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Date: Tuesday, February 11th

Time: 10:00 AM

Track: Diagnostics

Venue: Ziegfeld Room, New York Marriott Marquis, 1535 Broadway, New York, NY 10036

To schedule a meeting with Mark McDonough during the conference, please contact [email protected].

Sierra Oncology Completes Conversion of Preferred to Common Stock and Issues Stock to Gilead

On February 6, 2020 Sierra Oncology, Inc. (SRRA), a late-stage drug development company focused on the development and commercialization of momelotinib, a JAK1, JAK2 & ACVR1 inhibitor with a potentially differentiated therapeutic profile for the treatment of myelofibrosis, reported that the Series A convertible voting preferred stock issued in its recently completed $103.0 million financing (gross proceeds) have been fully converted into shares of common stock (Press release, Sierra Oncology, FEB 6, 2020, View Source [SID1234553971]).

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In addition, Gilead Sciences, Inc. (Gilead) has been issued 725,283 shares of common stock and a warrant to purchase an equivalent amount of common stock, in consideration for meaningfully reduced royalty rates and elimination of a near term milestone in an amendment to the Asset Purchase Agreement with Gilead for momelotinib, as previously announced.

"These announcements bring clarity to Sierra’s simplified go-forward capital structure. We are fortunate to have built both a healthy balance sheet and a critical mass of high quality, supportive shareholders, led by Vivo Capital, Longitude Capital, OrbiMed and Abingworth, investors in our recent financing and from which we appointed four new directors to Sierra’s Board, as well as Gilead. These stakeholders are aligned with Management in our focus on achieving regulatory and commercial success with our Phase 3 drug candidate, momelotinib, which has the potential to become an important therapeutic for both first and second line myelofibrosis patients, including the majority that suffer from anemia and thrombocytopenia," said Dr. Nick Glover, President and CEO of Sierra Oncology.

There are now 10,395,732 total shares of common stock outstanding and warrants to purchase 11,102,251 shares of common stock, with an exercise price equal to $13.20 per share. Of these warrants, warrants to purchase approximately 2,574,727 shares of common stock (the Series B warrants) may only be exercised by paying the exercise price in cash, and will expire on the 75th day anniversary following the announcement of top-line data from MOMENTUM, Sierra Oncology’s ongoing Phase 3 clinical trial of momelotinib. If these Series B warrants are fully exercised, the company will receive approximately $34.0 million in proceeds.

Sierra Oncology previously reported its cash and cash equivalents totaled $67.7 million as of September 30, 2019, and that subsequently it had closed an underwritten public offering with gross proceeds to Sierra Oncology of $103.0 million. Prior to the end of 2019, a term loan of $5.0 million was repaid to Silicon Valley Bank.

Athenex, Inc. to Report Fourth Quarter and Full Year 2019 Earnings Results on February 27, 2020

On February 6, 2020 Athenex, Inc. (Nasdaq: ATNX), a global biopharmaceutical company dedicated to the discovery, development, and commercialization of novel therapies for the treatment of cancer, reported that it will release fourth quarter and full year 2019 financial results on Thursday, February 27, 2020, before the market opens, and host a conference call and live audio webcast 8:00am Eastern Time to discuss the financial results and provide a business update (Press release, Athenex, FEB 6, 2020, View Source [SID1234573883]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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To participate in the call, dial 877-407-0784 (domestic) or 201-689-8560 (international) fifteen minutes before the conference call begins and reference the conference passcode 13698005. The live conference call and replay can also be accessed via audio webcast at the Investor Relations section of the Company’s website, located at View Source

Zetagen Therapeutics, Inc. Secures $5.34 Million in Series A Funding to Accelerate Clinical Work

On February 6, 2020 Zetagen Therapeutics, Inc., a private, clinical-stage, biopharmaceutical company dedicated to driving breakthrough innovation in the treatment of metastatic bone cancers and osteologic interventions, reported the close of $5.34M Series A funding round (Press release, Zetagen Therapeutics, FEB 6, 2020, View Source [SID1234643690]). The financing will accelerate the growth of the Company’s ongoing clinical programs for ZetaMet (Zeta-BC-003), a synthetic, small-molecule, inductive biologic being developed to target and resolve metastatic lesions while inhibiting future tumor growth.

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"We are extremely pleased to have reached such an important milestone in Zetagen’s advancement as a biopharmaceutical company, " said Joe C. Loy, CEO of Zetagen Therapeutics, Inc. "This funding is paramount to accelerating our clinical programs around ZetaMet (Zeta-BC-003) by adding the necessary scientific infrastructure that will allow us to prepare for future human clinical trials."

ZetaMet (Zeta-BC-003) is a novel molecular pathway paired with a proprietary, drug-eluting implant technology. The novel therapy is designed to resolve tumor growth, inhibit pain, and regenerate bone. Zetagen exclusively licensed the platform technology from the State University of New York in 2016.

Nimotuzumab-cisplatin-radiation versus cisplatin-radiation in HPV negative oropharyngeal cancer

On February 6, 2020 Oncotarget Volume reported in this study, locally advanced head and neck cancer patients undergoing definitive chemoradiation were randomly allocated to weekly cisplatin – radiation {CRT arm} or nimotuzumab -weekly cisplatin -radiation {NCRT arm} (Press release, Oncotarget, FEB 6, 2020, View Source [SID1234553940]).

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An interaction test was performed between the study arms and HPV status prior to doing any HPV specific analysis for each of the studied outcomes.

We had 187 HPV negative oropharyngeal cancers, 91 in the CRT arm and 96 in NCRT arm.

The addition of nimotuzumab to weekly cisplatin-radiation improves outcomes inclusive of OS in HPV negative oropharyngeal cancers.

Dr. Kumar Prabhash from the Department of Medical Oncology at the Tata Memorial Hospital, HBNI in Mumbai India said in their Oncotarget research article, "Locally advanced oropharyngeal cancers possess a unique challenge."

Patients with HPV positive disease have a favorable prognosis as opposed to HPV negative disease.

They had hypothesized that an improvement in outcomes in our study was seen due to the differential patient population in our study when compared to the RTOG 0552 study.

Another phase 3 study, exploring the role of cetuximab along with carboplatin -5 FU with radiation, reported improvement in outcomes with the addition of cetuximab.

Taking this into consideration, the authors decided to perform a subgroup analysis of the HPV negative oropharyngeal cancer cohort, to study the absolute improvement in 2-year outcomes with the addition of nimotuzumab.

The Prabhash Research Team concluded in their Oncotarget article that an interaction test was performed prior to doing the subgroup analysis, to determine whether nimotuzumab had a differential impact or not.