On January 6, 2020 Jazz Pharmaceuticals plc (Nasdaq: JAZZ) reported that the company will be webcasting its corporate presentation at the 38th Annual J.P. Morgan Healthcare Conference in San Francisco, CA (Press release, Jazz Pharmaceuticals, JAN 6, 2020, View Source [SID1234552751]).

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Bruce Cozadd, chairman and chief executive officer, will provide an overview of the company and a business and financial update at the conference on Monday, January 13, 2020 at 10:00 a.m. PST / 6:00 p.m. GMT.

A live audio webcast of the presentation may be accessed from the Investors section of the Jazz Pharmaceuticals website at www.jazzpharmaceuticals.com. Please connect to the website prior to the start of the presentation to ensure adequate time for any software downloads that may be necessary to listen to the webcast.

An archive of the webcast will be available on the website for at least one week following the presentation on the Investors section of the company’s website at www.jazzpharmaceuticals.com.

On January 6, 2020 Yisheng Biopharma Co., Ltd. ("Yisheng Biopharma"), a biopharmaceutical company focusing on research, development, manufacturing, sales and marketing of immunological biologics and vaccines, and Tavotek Biotherapeutics, a biotech company focusing on novel multi-specific antibodies in immuno-oncology and autoimmune diseases, reported that the companies have entered into a strategic research alliance and collaborate in the development involving their lead assets in oncology (Press release, Yisheng US Biopharma, JAN 6, 2020, View Source [SID1234552768]). The objective of the alliance is to co-develop a combination therapy of YS-ON-001/002 and Tavo-301/303 for cancer treatment. The two companies are also in discussions regarding additional research and development collaborations beyond oncology.

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"We are excited to collaborate with Tavotek, which has a rich pipeline of multi-specific antibodies and advanced technology platforms in oncology and other therapeutic areas," commented Dr. David Shao, President and Chief Executive Officer of Yisheng Biopharma. "As potent agonists of TLR3, MDA5 and RIG-I pathways, YS-ON-001 and YS-ON-002 have demonstrated promising effects in activating the innate and adaptive immune systems and modulating the tumor microenvironment, and YS-ON-001 has shown an excellent safety profile with clinical data to date. By combining YS-ON-001/002 with multi-specific antibodies directed against tumors, we are well positioned in developing a first-in-class immunotherapy with potentially higher response rates. We look forward to working with the Tavotek team to explore the potential synergy of YS-ON-001/002 and Tavo-301/303."

"The collaboration with Yisheng aligns with Tavotek’s mission to develop life-changing therapies for patients with significant unmet medical need," said Dr. Mann Fung, Chief Executive Officer of Tavotek. "Current immuno-oncology approaches such as PD1/PDL1 antibody achieve only approximately 20 to 30 percent response rates in clinical settings. A majority of cancer patients still are not seeing a benefit from current therapies. We believe a combination regimen of YS-ON-001/002 with multi-specific IO antibodies, such as Tavo-301/303, will have beneficial impact on cancer care."

YS-ON-001 and YS-ON-002 are immunotherapeutic products based on the TLR3/RIG-I/MDA-5 signaling pathways of PIKA immunomodulating technology. They are capable of both reducing the immunosuppressive effect of tumor microenvironment and enhancing the anti-tumor function of the immune system to tumor cells. YS-ON-001 is currently in clinical development in China and Singapore, and has received orphan drug designations from the U.S. FDA for treatment of pancreatic and liver cancers. The product has been approved in Cambodia for the treatment of advanced solid tumors. YS-ON-002 is a clinical candidate ready for IND submission. YS-ON-001/002 can be an integral immunotherapy component with standard of oncology care, such as chemotherapies, targeted therapies and checkpoint inhibitors or with emerging immunotherapies for additive or synergistic treatment benefits.

Tavo-301/303 is a series of novel multi-specific antibody-based Immuno-Oncology assets that was developed using Tavotek’s proprietary TavoSelect Platform. Novel protein engineering employing TavoSelect technology generates multi-specific biologics with optimal molecular profiles for targeting multiple relevant epitopes simultaneously to manage difficult-to-treat solid tumors. These biologics modulate the immunosuppressive pathway by multiple mechanisms of action to promote anti-tumor response and efficacy. The TavoSelec technology also provides biologic molecules with favorable pharmacokinetic profiles and stable formats for ease of development and manufacturing.

On January 6, 2020 Astellas Pharma Inc. (TSE: 4503, President and CEO: Kenji Yasukawa, Ph.D. "the Company") reported the status of acquisition of its own shares as stated below (Press release, Astellas, JAN 6, 2020, View Source [SID1234552693]). The acquisition was implemented pursuant to the provision of its Articles of Incorporation in accordance with Article 459, paragraph 1 of the Companies Act.

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Particulars

1. Class of shares acquired: Common stock of the Company

2 Total number of shares acquired: 7,360,600 shares

3 Total amount of acquisition cost: 13,738,364,050 yen

4 Period of acquisition: From December 1, 2019 to December 23, 2019

5 Method of acquisition: Purchased on the Tokyo Stock Exchange

(Reference)

1. Details of the resolution at the meeting of the Board of Directors (announced on October 31, 2019)
-Class of shares to be acquired: Common stock of the Company

-Total number of shares to be acquired: Up to 32 million shares (Ratio to the total number of shares outstanding [excluding treasury stock]: 1.70%)

-Total amount of acquisition cost: Up to 50 billion yen

-Period of acquisition: From November 1, 2019 to January 31, 2020

2. Accumulated Company’s own shares acquired through December 31, 2019, pursuant to the above board resolution

-Total number of shares acquired: 20,026,200 shares

-Total amount of acquisition cost: 36,866,306,500 yen

On January 6, 2020 Genmab A/S (Nasdaq: GMAB) reported that its CEO, Jan van de Winkel, Ph.D., will present a company update at the 38th Annual J.P. Morgan Healthcare Conference in San Francisco at 3:30 PM PST on January 15, 2020 (12:30 AM CET, January 16) (Press release, Genmab, JAN 6, 2020, View Source [SID1234552719]). The live and archived webcast of the presentation will be available on Genmab’s website at View Source

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On January 6, 2019 Moderna, Inc., (Nasdaq: MRNA) a clinical stage biotechnology company pioneering messenger RNA (mRNA) therapeutics and vaccines to create a new generation of transformative medicines for patients, reported that CEO Stéphane Bancel will present an update on the Company and its pipeline of mRNA development programs at this year’s 38th annual J.P. Morgan Healthcare Conference (Press release, Moderna Therapeutics, JAN 6, 2020, View Source [SID1234552736]).

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Mr. Bancel’s presentation will take place on Monday, January 13, 2020 at 4:30 p.m. PT in the Colonial Room at The Westin St. Francis Hotel in San Francisco. The presentation will be followed by a question and answer session. A live webcast of both the presentation and question and answer session will be available under "Events & Presentations" in the investors section of Moderna’s website at View Source A replay of the webcast will be archived on Moderna’s website for 30 days following the presentation.