Aptose Announces $4.43 Million Registered Direct Offering Priced At-the-Market Under Nasdaq Rules

On May 31, 2024 Aptose Biosciences Inc. ("Aptose" or the "Company") (NASDAQ: APTO, TSX: APS), a clinical-stage precision oncology company developing highly differentiated oral targeted agents to treat hematologic malignancies, reported that it has entered into a definitive agreement for the issuance and sale of 3,855,000 of its common shares (or common share equivalents in lieu thereof) at a purchase price of $1.15 per share (or per common share equivalent in lieu thereof) in a registered direct offering priced at-the-market under Nasdaq rules (Press release, Aptose Biosciences, MAY 31, 2024, View Source [SID1234643900]). Additionally, in a concurrent private placement, Aptose has agreed to issue unregistered series A warrants to purchase up to 3,855,000 common shares and series B warrants to purchase up to 3,855,000 common shares, each at an exercise price of $1.15 per share. The unregistered warrants will be exercisable beginning on the effective date of shareholder approval of the issuance of the shares issuable upon exercise of the warrants. The series A warrants will expire five years from the date of shareholder approval and the series B warrants will expire eighteen months from the date of shareholder approval. The offering is expected to close on or about June 3, 2024, subject to the satisfaction of customary closing conditions.

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H.C. Wainwright & Co. is acting as the exclusive placement agent for the offering.

The gross proceeds to the Company from the offering are expected to be approximately $4.43 million, before deducting the placement agent’s fees and other offering expenses. The Company currently intends to use the net proceeds from the offering for working capital and general corporate purposes.

The common shares (or common share equivalents in lieu thereof) offered in the registered direct offering (but excluding the unregistered warrants or the common shares underlying such unregistered warrants) described above are being offered pursuant to a "shelf" registration statement on Form S-3 (Registration No. 333-267801), including a base prospectus, initially filed with the Securities and Exchange Commission ("SEC") on October 11, 2022, and declared effective by the SEC on October 21, 2022. The offering of the common shares (or common share equivalents in lieu thereof) are being made only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. A final prospectus supplement and an accompanying base prospectus relating to, and describing the terms of, the registered direct offering will be filed with the SEC and will be available on the SEC’s website located at View Source Electronic copies of the prospectus supplement and accompanying base prospectus relating to the registered direct offering, when available, may also be obtained from H.C. Wainwright & Co., LLC at 430 Park Ave., New York, New York 10022, by telephone at (212) 856-5711, or by email at [email protected].

The unregistered warrants have not been registered under the Securities Act of 1933 and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.

Agendia to Present New Data on 3-Year Outcome of Chemotherapy Treatment in Patients with Early-Stage Breast Cancer at 2024 ASCO

On May 31, 2024 Agendia, Inc. reported it will present new data on the 3-year outcome of patients with hormone receptor-positive (HR+), HER2-negative early-stage breast cancer when treated with two different chemotherapy regimens at the 2024 Annual American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Meeting, taking place in Chicago, IL. on May 31st, 2024 (Press release, Agendia, MAY 31, 2024, View Source [SID1234643916]).

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The data will be presented in an oral discussion by Joyce O’Shaughnessy MD, Director, Breast Cancer Research, Baylor University Medical Center, Texas Oncology and the Sarah Cannon Research Institute in Dallas, TX, Primary Investigator of the FLEX Study, titled Association of MammaPrint index and 3-year outcome of patients with HR+HER2- early-stage breast cancer treated with chemotherapy with or without anthracycline [O’Shaughnessy, J., et al.]. The FLEX study investigates the 3-year outcome of patients with HR+HER2-, genomically High Risk Luminal B-Type early breast cancer, who have undergone treatment consisting of chemotherapy with taxane and cyclophosphamide (TC) or chemotherapy with anthracycline + TC (AC-T). All patients are enrolled in the prospective, non-randomized, observational FLEX Study (NCT03053193). This study utilized both MammaPrint and BluePrint to determine tumor subtype.

Results showed that patients with MammaPrint H1 Luminal B-Type tumors demonstrated similar 3-year outcomes when treated with either TC (97.1%) or AC-T (95.3%), suggesting that patients who are classified as H1 may be able to avoid the toxicity of an anthracycline. However, patients with MammaPrint H2 Luminal B-Type tumors demonstrated a significantly higher relapse-free survival when treated with AC-T (97.7%) than with TC alone (86.4%). These findings indicate that MammaPrint H2 tumors benefit from the addition of an anthracycline to their adjuvant chemotherapy regimen.

"The ability to tailor treatment regimens to a patient’s tumor biology is crucial to optimize outcomes and quality of life. MammaPrint’s utility in guiding treatment planning is highlighted by these new data evaluating chemotherapy selection," said Dr. O’Shaughnessy. "The FLEX Study and sub-studies, such as this one, enable increased precision in identifying patients that are more responsive to specific systemic therapy regimens, and continue to aid selection of treatments for patients with HR+/HER2-negative early-stage breast cancer."

"These new findings demonstrate the strength of the FLEX research platform in evaluating the different aspects of breast cancer during its diagnosis and treatment stages, allowing for more precise and individualized treatment recommendations," said William Audeh, MD, Chief Medical Officer at Agendia. "This study offers a preliminary signal towards groundbreaking insight into MammaPrint High Risk tumors and how they best respond to chemotherapy regimens, underscoring the clinical utility of MammaPrint in the selection of treatment. We remain committed to advancing breast cancer research to help deliver the best standard of practice to women undergoing breast cancer care."

Additional data supporting MammaPrint utility in treatment selection will be presented by investigators from the ISPY2 trial in a poster titled Hormone Receptor Positive HER2-negative/MammaPrint High-2 Breast Cancer Closely Resembles Triple Negative Breast Cancer: Results from Gene Expression Data from the ISPY2 Trial [Rios-Hoyo, A., et al.]. By using data from the ISPY-2 trial, this poster demonstrates that MammaPrint H2 tumors have molecular and clinical similarities to triple negative breast cancer tumors, underscoring critical insight into how treatment plans can be optimized to achieve the best result for the patient.

Agendia will be sharing updates throughout the conference on its Twitter, Facebook and LinkedIn pages.

Bexion Pharmaceuticals, Inc. toPresent at BIO InternationalConvention 2024

On May 31, 2024 Bexion Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company developing a new generation of biologic therapy to treat solid tumor cancers and chemotherapy-induced peripheral neuropathy (CIPN), reported that the Company will present at the 2024 Biotechnology Innovation Organization (BIO) International Convention taking place June 3-6, 2024, in San Diego, California (Press release, Bexion, MAY 31, 2024, View Source [SID1234643901]).

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Presentation Details:

Location: Theater 1, Hall A, Exhibition Hall

Session Date and Time: Wednesday, June 5 at 11:15am PT

"We are delighted to participate in the BIO International Convention in San Diego," said Scott Shively, Bexion’s Chief Executive Officer. "Bexion is approaching critical milestones for our mCRC and CIPN clinical programs, and we look forward to sharing the tremendous progress our team has made."

To schedule a meeting at the BIO International Convention with Bexion Pharmaceuticals, please submit a meeting request through the BIO One-on-One Partnering platform. More details are available on the BIO International Convention 2024 website.

About BIO International Convention

The BIO International Convention is the largest and most comprehensive event for biotechnology, representing the full ecosystem of biotech with over 20,000 industry leaders from across the globe. The convention includes innovative programming around the current and future state of biotech including areas like therapeutic frontiers, the business of biotech, regulatory and policy outlooks, and human capital.

About BXQ-350

Bexion’s lead drug candidate is BXQ-350, a first-in-class biologic containing the multifunctional, sphingolipid activator protein, Saposin C, and a phospholipid. BXQ-350 has pre-clinical antitumor effects in vitro and in vivo, particularly in colorectal, brain and other solid tumors. Two Phase 1 clinical trials, one in adults and one in pediatric DIPG patients, demonstrated a strong safety profile for BXQ-350 with evidence of single agent activity across multiple solid tumors. Additionally, other clinical and non-clinical data suggest BXQ-350 has activity in chemotherapy-induced peripheral neuropathy.

Artera Announces Three Presentations at ASCO 2024 That Demonstrate the Reliability and Depth of its AI Cancer Platform

On May 31, 2024 Artera, the developer of multimodal artificial intelligence-based prognostic and predictive cancer tests, reported that it will present three abstracts at the 2024 ASCO (Free ASCO Whitepaper) Annual Meeting demonstrating that its multimodal artificial intelligence (MMAI) platform provides significant prognostic value across various stages of prostate cancer and for early stage breast cancer (Press release, Artera, MAY 31, 2024, View Source [SID1234643917]). These studies build upon the first AI-enabled test that delivers prognostic and predictive insights for localized prostate cancer patients: ArteraAI Prostate Test.

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"Medicine is filled with instances where the seed of an idea took years to grow into an innovative tool that changes the standard way of practice," said Andre Esteva, CEO of Artera. "Currently, cancer care strongly emphasizes biochemistry and molecular biology, and advancements can take decades to develop and adopt. Artera’s model offers a novel way of thinking, utilizing AI and image analysis to significantly fast-track innovation and advancements in cancer care, demonstrating performance across diverse patient cohorts. We are proud to be working on this new way forward."

The MMAI platform can provide results to support personalized therapy by combining a patient’s unique clinical data with their pathology slides. Artera is taking a unique approach to this by applying AI to images of hematoxylin and eosin (H&E)-stained pathology slides to provide prognostic and predictive results.

Traditionally, after a cancer diagnosis, additional insights to support a more personalized treatment plan can require multiple tests – an approach that can be expensive and hard to scale due to the complicated process of identifying and quantifying the correct genomic biomarkers across different disease states and patient populations. Artera created AI-enabled algorithms that use digitized whole slide images of the H&E slides to be able to provide personalized results in a way that can potentially boost confidence for patients and their clinicians that they are making the optimal treatment choices throughout their journey.

"Using the MMAI platform on these different groups of patients, with different types and stages of cancer, and getting clinically actionable results demonstrates just how reliable analyzing H&E slides, which are already created during the routine course of care, can be for predicting risk to personalize treatment," said Trevor Royce, MD MPH, Senior Medical Director at Artera. "This approach to cancer research has the potential to transform the future of cancer care."

This announcement follows Artera’s recent presentation at the 2024 AUA Annual Meeting, which validated the first AI-based biomarker to stratify the risk of metastasis in patients with biochemical recurrence after radical prostatectomy, showing the company’s continued commitment to extending its platform to patients at various stages of prostate cancer.

As more treatment options become available to patients, being able to personalize their treatment plan can aid in mitigating negative side effects from unnecessary treatment and increase confidence in decision-making. Artera is focused on continuing to train and validate other biomarkers using this platform, so more patients with prostate cancer at different stages, as well as other disease states such as breast cancer, will be able to use this tool that can one day personalize their treatment plans.

The three presentations include:

Oral Presentation: Multimodal artificial intelligence models from baseline histopathology to predict prognosis in HR+ HER2- early breast cancer: Subgroup analysis
Abstract Number: 101
Session Type and Title: Clinical Science Symposium – Using "Artificial" Intelligence to Achieve "Real" Improvements in Cancer Care
Date and Time: June 1, 2024 at 8:00 AM-9:30 AM CDT

Poster Presentation: Validation of a digital pathology-based multimodal artificial intelligence model in oligometastatic castration-sensitive prostate cancer, including in patients from the STOMP and ORIOLE phase II randomized clinical trials.
Abstract Number: 5080
Session Type and Title: Poster Session – Genitourinary Cancer—Prostate, Testicular, and Penile
Date and Time: June 2, 2024 at 9:00 AM-12:00 PM CDT

Poster Presentation: Prognostic validation of a digital pathology-based multi-modal artificial intelligence (MMAI) biomarker in patients with metastatic hormone-sensitive prostate cancer (mHSPC) from the CHAARTED trial (ECOG-ACRIN EA3805).
Abstract Number: 5077
Session Type and Title: Poster Session – Genitourinary Cancer—Prostate, Testicular, and Penile
Date and Time: June 2, 2024 at 9:00 AM-12:00 PM CDT

For more information on Artera, visit Artera.ai.

BIO-TECHNE TO PRESENT AT UPCOMING INVESTOR CONFERENCES

On May 31, 2024 Bio-Techne Corporation (NASDAQ: TECH) reported that Kim Kelderman, President and Chief Executive Officer will present at the following investor conferences (Press release, Bio-Techne, MAY 31, 2024, View Source [SID1234643902]):

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William Blair 44th Annual Growth Conference
June 4, 2024
9:20 AM CDT

Jefferies Global Healthcare Conference
June 6, 2024
9:30 AM EDT

Goldman Sachs 45th Annual Global Healthcare Conference
June 11, 2024
9:20 AM EDT

A live webcast of the presentations can be accessed via the IR Calendar page of Bio-Techne’s Investor Relations website at View Source