AMAG Pharmaceuticals Appoints Scott Myers as President and Chief Executive Officer

On April 28, 2020 AMAG Pharmaceuticals, Inc. (NASDAQ: AMAG) reported that its Board of Directors has appointed Scott Myers as AMAG’s President and Chief Executive Officer, and member of the Board, effective immediately (Press release, AMAG Pharmaceuticals, APR 28, 2020, View Source [SID1234556697]). Mr. Myers succeeds William Heiden, who is stepping down from such roles in light of Mr. Myers’ appointment.

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"Scott is a seasoned leader with exceptional experience, skill set and passion, and it became evident to the Board through its rigorous search that Scott is the ideal candidate to lead AMAG forward," said Gino Santini, Chairman of AMAG’s Board. "Scott’s track record of success, coupled with his experience leading companies with development stage and commercialized assets, uniquely positions him to lead the Company. The Board is confident that Scott will maximize AMAG’s strengths and proven capabilities and enable the Company to better serve patients."

Mr. Santini added, "The Board of Directors would like to thank Bill for his dedication and leadership over the past eight years. We appreciate Bill’s contributions to AMAG and we wish him the best in his future endeavors."

Mr. Myers is a proven executive who brings nearly three decades of global pharmaceutical and medical technology experience to AMAG. Mr. Myers most recently served as Chairman and Chief Executive Officer of Rainier Therapeutics, a clinical-stage biotechnology company focused on metastatic bladder cancer. Prior to joining Rainier, Mr. Myers served as Chief Executive Officer, President and as a director of Cascadian Therapeutics Inc. Mr. Myers also served as Chief Executive Officer of Aerocrine AB, a medical device company from 2011 to 2015. While at the helm of these companies, Mr. Myers drove transformation that maximized growth and delivered significant long-term value.

"AMAG is at a pivotal point in its evolution and I look forward to working with AMAG’s Board, its leadership team and its dedicated employees to advance the strategic plan, further define the Company’s future, optimize its current products and bring innovative therapies to patients in need," said Mr. Myers. "We have a significant opportunity ahead of us to unlock the potential of AMAG’s pipeline and leverage its existing commercial strengths to drive long-term growth and shareholder value."

Mr. Myers is currently an independent director of Selecta Biosciences where he serves as the Chair of the Compensation and Benefits Committee, as well as a member of the Nominating and Governance Committee. Mr. Myers also serves as an independent director for Harpoon Therapeutics, a clinical stage biotechnology company where he serves on the Audit Committee. Mr. Myers began his career in management consulting and then moved into the pharmaceutical industry through senior leadership roles at Johnson & Johnson, DOV Pharmaceuticals and UCB.

Mr. Myers holds a Bachelor of Arts in Biology from Northwestern University in Evanston, Illinois, and a Master of Business Administration from The University of Chicago Graduate School of Business (Booth) in Chicago, Illinois.

Inducement Equity Awards
The Board of Directors of AMAG approved an inducement award to Mr. Myers of an option to purchase 1,000,000 shares of common stock. The option will have an exercise price equal to the closing price of AMAG’s common stock on the grant date and will be exercisable in four equal annual installments beginning on the first anniversary of April 28,2020 (the grant date). The option will have a ten-year term and be subject to the terms and conditions of the stock option agreement pursuant to which the option will be granted. This equity award will be granted without stockholder approval as inducements material to the employee entering into employment with AMAG in accordance with NASDAQ Listing Rule 5635(c)(4).

Nektar to Announce Financial Results for the First Quarter 2020 on Thursday, May 7, 2020, After Close of U.S.-Based Financial Markets

On April 28, 2020 Nektar Therapeutics (Nasdaq: NKTR) reported that it will announce its financial results for the first quarter 2020 on Thursday, May 7, 2020, after the close of U.S.-based financial markets (Press release, Nektar Therapeutics, APR 28, 2020, View Source [SID1234556717]). Howard Robin, President and Chief Executive Officer, will host a conference call to review the results beginning at 5:00 p.m. Eastern Time/2:00 p.m. Pacific Time.

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The press release and live audio-only webcast of the conference call can be accessed through a link that is posted on the home page and Investors section of the Nektar website: View Source The web broadcast of the conference call will be available for replay through Monday, June 1, 2020.

To access the conference call, follow these instructions:
Dial: (877) 881-2183 (U.S.); (970) 315-0453 (international)
Conference ID: 8288857 (Nektar Therapeutics is the host)

Paul Jenkins appointed Interim CEO of Cellesce to accelerate deployment of Company strategy

On April 28, 2020 Cellesce’s Board of Directors reported the appointment of Paul Jenkins as Interim CEO as from 28th April, 2020 (Press release, Cellesce, APR 28, 2020, View Source [SID1234556681]). Paul takes over as CEO from Mark Treherne, who has been CEO since May 2018, and will now focus on his other existing directorships.

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John Allbrook (Non-Executive Chairman of Cellesce) said, "On behalf of the Board I would like to thank Mark for his all his effort and accomplishments over the last 2 years, which have seen the Company make good progress. Under Mark’s stewardship the Company has taken significant steps forward in the development and deployment of its core Organoid Bioprocessing technology, partially funded by a series of successful grant applications. At the same time, the Company has started to gain commercial traction and realised strong revenue growth. I am delighted to welcome Paul Jenkins to Cellesce. These are extraordinary times and the Covid-19 pandemic is presenting all businesses with a unique set of challenges. I am confident with Paul at the helm that Cellesce will rise to these challenges and continue to build on the excellent foundations already in-place."

"Paul is a seasoned business development and senior management executive in Life Sciences. He has amassed a wealth of deal-making and investment experience across a variety of therapeutic areas. Paul’s previous roles include VP Business Development at Catalent, CEO at Adjuvantix, and VP Business Development at West Pharmaceutical Services. Paul is also a strategic advisor to Yorkshire Cancer Research."

Cellesce has developed a new patented bioprocessing technology for the growth and expansion of Patient-Derived Organoids. Organoids are 3-D cell structures with organ-like characteristics grown from adult stem cells. The Company is commercialising its platform, which is a powerful new enabling technology in early-stage drug discovery for multiple types of cancer.

Positive Opinion for Orphan Drug Designation for ADP-A2M4 for the Treatment of Soft Tissue Sarcoma from European Medicine Agency’s Committee of Orphan Medicinal Products

On April 28, 2020 Adaptimmune Therapeutics plc (Nasdaq:ADAP), a leader in cell therapy to treat cancer, reported that the European Medicine Agency’s (EMA) Committee for Orphan Medicinal Products (COMP) has adopted a positive opinion for Orphan Drug Designation for ADP-A2M4 for the treatment of soft tissue sarcomas (Press release, Adaptimmune, APR 28, 2020, View Source [SID1234556698]).

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Adaptimmune’s SPEARHEAD-1 trial with ADP-A2M4 for people with synovial sarcoma and myxoid/round cell liposarcoma (MRCLS) is actively enrolling at approximately 25 clinical sites in Canada, France, Spain, the United Kingdom, and the US. The SPEARHEAD-1 trial is intended to support the registration of ADP-A2M4 for the treatment of advanced synovial sarcoma and MRCLS.

"Outcomes with currently available treatments remain unsatisfactory for patients with inoperable or metastatic soft tissue sarcoma, and there is a high unmet medical need for new treatment options for patients with this disease," said Dennis Williams, PharmD, Adaptimmune’s SVP, Late Stage Development. "ADP-A2M4 has the potential to offer substantial improvement in the treatment of advanced soft tissue sarcoma and the COMP’s adoption of a positive opinion for Orphan Drug Designation for ADP-A2M4 is another important milestone for this program."

The COMP adopts an opinion on the granting of orphan drug designation, after which the opinion is submitted to the European Commission for endorsement. This designation by the European Commission provides certain regulatory and financial incentives for companies to develop and market therapies that treat a life-threatening or chronically debilitating condition affecting no more than five in 10,000 persons in the European Union, and where the treatment provides a significant benefit to those affected by the condition or no satisfactory treatment is available.

Earlier this year, the United States (US) Food and Drug Administration (FDA) granted Orphan Drug Designation (ODD) to SPEAR T-cells targeting MAGE-A4 for the treatment of soft tissue sarcomas and Regenerative Medicine Advanced Therapy (RMAT) designation for the treatment of synovial sarcoma.

Synthetic Biologics to Report 2020 First Quarter Operational Highlights and Financial Results on May 5, 2020

On April 28, 2020 Synthetic Biologics, Inc. (NYSE American: SYN), a diversified clinical-stage company leveraging the microbiome to develop therapeutics designed to prevent and treat gastrointestinal (GI) diseases in areas of high unmet need, reported that the Company intends to release its operational highlights and financial results for the quarter ended March 31, 2020 on Tuesday, May 5, 2020, and to host a conference call the same day at 4:30 p.m. ET (Press release, Synthetic Biologics, APR 28, 2020, View Source [SID1234556718]). The dial-in information for the call is as follows:

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U.S. (toll free): 1-888-347-5280
International: +1-412-902-4280

Participants are asked to dial in 15 minutes before the start of the call to register. The call will also be webcast over the Internet at View Source." target="_blank" title="View Source." rel="nofollow">View Source An archived replay of the call will be available for approximately ninety (90) days at the same URL, View Source beginning approximately one hour after the call’s conclusion.