GlycoMimetics to Report First Quarter Financial Results on May 1, 2020

On April 24, 2020 GlycoMimetics, Inc. (Nasdaq: GLYC) reported that it will host a conference call and webcast to report its first quarter financial results on Friday, May 1, 2020, at 8:30 a.m. ET (Press release, GlycoMimetics, APR 24, 2020, View Source [SID1234556586]).

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The dial-in number for the conference call is (844) 413-7154 for domestic participants and (216) 562-0466 for international participants, with participant code 4567397. A webcast replay will be available via the "Investors" tab on the GlycoMimetics website for 30 days following the call. A dial-in phone replay will be available for 24 hours after the close of the call by dialing (855) 859-2056 for domestic participants and (404) 537-3406 for international participants, participant code 4567397.

We encourage speakers and participants to connect early to ensure that all callers are able to connect. Perhaps, include language in earnings announcement and release to remind all speakers/participants to dial in 15 minutes prior to the call start time. Also, any callers who would like to ask questions, to queue early in the call.

Oncocyte Announces $10.7 Million Registered Offering

On April 24, 2020 Oncocyte Corporation (NYSE American: OCX), a molecular diagnostics company with a mission to provide actionable answers at critical decision points across the cancer care continuum, reported that it has entered into definitive agreements with, among other institutional investors, Blackcrane Capital, LLC, an investment management company employing an unconstrained, change-oriented investment approach, to purchase approximately $10.7 million of Oncocyte’s common shares in a registered offering priced "at market", which was the closing price immediately preceding the offering (Press release, Oncocyte, APR 24, 2020, View Source [SID1234556663]). This offering was completed directly with the institutional investors and the Company incurred no placement agent fees.

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"Our continued ability to attract support from healthcare focused funds stems from our remarkable progress in advancing our expanding suite of tests which now address treatment stratification and immunotherapy response prediction for lung cancer and liquid biopsy to rule out malignancy in lung nodules," said Ron Andrews, Chief Executive Officer of Oncocyte. "Our strengthened balance sheet will facilitate our continued progress and execution, now as a commercial stage company, as we work to grow our market and further expand our offerings in lung and beyond."

Daniel Kim, founder and chief executive of Blackcrane Capital, LLC, said "We are excited to partner with Oncocyte as they work to provide decisive answers for patients across the lung cancer care continuum. We see tremendous potential at Oncocyte based on their deep clinical and commercial expertise and proven track record of success. We are very excited to support Oncocyte’s management team as it continues to work towards improving lung cancer diagnosis, treatment and patient outcomes."

In connection with the offering, the Company will sell an aggregate of 4,733,700 shares of its common stock at a purchase price of $2.27 per share, the closing price of the stock on April 23, 2020, the day prior to the execution of the agreement with the investors. The registered offering is subject to customary closing conditions and is expected to close during the week of April 27, 2020.

Proceeds from the registered offering provide the strategic capital to accelerate and support the commercial launch of DetermaRx, OncoCyte’s lung cancer treatment stratification test, DetermaIO, a research use only gene expression test to identify immune checkpoint inhibitor responders, and the continued development of DetermaDx a liquid biopsy test to rule out malignancies in lung nodules as well as general corporate and working capital purposes. The Company may also use proceeds to invest in or acquire businesses or technologies that it believes are complementary, although the Company has no binding agreements with respect to any strategic transactions or acquisitions as of the date of this press release.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any offer, solicitation or sale of these securities in any state or other jurisdiction in which such an offer, solicitation or sale would be unlawful.

QIMR Berghofer signs commercial agreement with EpimAb Biotherapeutics

On April 24, 2020 QIMR Berghofer Medical Research Institute reported that it has entered a research collaboration and licence agreement with Shanghai-based biopharmaceutical company EpimAb Biotherapeutics to develop bi-specific antibodies against immuno-oncology targets (Press release, QIMR Berghofer Medical Research Institute, APR 24, 2020, View Source [SID1234556536]).

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The novel targets were identified by QIMR Berghofer visiting scientist Professor Bill Dougall and the Coordinator of the Institute’s Immunology Department, Professor Mark Smyth.

Under the agreement, the researchers will test antibodies that act on two immune targets simultaneously using EpimAb’s platform Fabs-In-Tandem Immunoglobulin (FIT-Ig).

Under the terms of the agreement, EpimAb has been granted an exclusive licence to develop the bi-specific antibodies.

QIMR Berghofer’s Acting Director and CEO, Professor David Whiteman AM, welcomed the agreement.

"Professors Bill Dougall and Mark Smyth are world leaders in identifying new immune targets for cancer," he said.

"By partnering with EpimAb – a company that specialises in developing bispecific antibodies – we hope to speed up the development of much-needed new cancer immunotherapies."

Professor Smyth said the bispecifics field had opened up new potential avenues to treat cancer.

"Existing immune checkpoint therapies usually act on a single immune target," Professor Smyth said.

"By developing antibodies that target two immune checkpoints simultaneously, we hope to produce a stronger anti-cancer response.

"EpimAb’s unique platform technology will allow us to further evaluate some of our most recent discoveries."

EpimAb’s CEO and founder, Dr Chengbin Wu, said he looked forward to using the company’s technology to evaluate novel bispecific target pairs developed under the collaboration.

"QIMR Berghofer is one of the pioneering institutes in the discovery of immuno-oncology mechanisms which are playing an important role in today’s treatment of cancer," Dr Wu said.

"We are proud to collaborate with QIMR Berghofer to identify novel target combinations as EpimAb enters the next stage of growth."

The terms of the agreement are commercial-in-confidence.

Pfenex to Announce First Quarter 2020 Financial Results on May 7

On April 24, 2020 Pfenex Inc. (NYSE American: PFNX) reported that it will report its financial results for the first quarter ended March 31, 2020, after the market close on Thursday, May 7, 2020 (Press release, Pfenex, APR 24, 2020, View Source [SID1234556587]). Pfenex will host a conference call and webcast to discuss its financial results and provide a company update that day at 1:30 PM Pacific Time (4:30 PM Eastern Time).

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Conference Call & Webcast
Thursday, May 7th @ 1:30 PM Pacific Time (4:30 PM Eastern Time)
Domestic: 888-220-8451
International: 856-344-9221
Conference ID: 3922891
Webcast: View Source

Webcast replays available through May 14th:
Webcast: View Source

Rasna Therapeutics Sells its Nanoparticle-Based Formulation Technology for Controlled Delivery of Actinomycin D for Acute Myeloid Leukemia to Tiziana Life Sciences plc

On April 24, 2020 Rasna Therapeutics, Inc. (OTCQB: RASP), a development stage biotechnology company focused on the development of disease-modifying drugs for hematological malignancies, reported it has sold all of the intellectual property relating to a nanoparticle-based formulation of Actinomycin D (Act D; a.k.a. Dactinomycin) to Tiziana Life Sciences plc pursuant to an asset purchase agreement in exchange for an upfront payment of $120,000 and milestone payments of up to an aggregate $630,000 (Press release, Rasna Therapeutics, APR 24, 2020, View Source [SID1234556588]). Rasna is continuing to develop NPM1-mutated AML through direct and indirect disease-modifying approaches as well as inhibition of lysine specific demethylase-1 (LSD1), an enzyme involved in epigenetic control, as a promising and novel approach against AML.

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About NP-Act D

Actinomycin D, an inhibitor of RNA-dependent RNA polymerase, is a potent antibiotic with therapeutic utilities in infectious diseases. Actinomycin was approved for medical use in the United States in 1964. It is on the World Health Organization’s List of Essential Medicines, the safest and most effective medicines needed in a health system. Currently, the drug is primarily used for infectious diseases but recent studies suggest potential of this drug in certain cancers as well. However, intravenously administered Actinomycin D is known to produce severe toxicities, its therapeutic utility has been limited. The nanoparticle-based Actinomycin D (NP-ACT D) is formulated to control and slow release of Act D such that the Cmax in blood can be adjusted. In animal studies, NP-Act D was found to produce minimal toxicities and it was found to safe and well-tolerated.