On April 15, 2020 Xenetic Biosciences, Inc. (NASDAQ:XBIO) ("Xenetic" or the "Company"), a biopharmaceutical company focused on advancing XCART, a personalized CAR T platform technology engineered to target patient- and tumor-specific neoantigens, reported that Jeffrey Eisenberg, Chief Executive Officer of Xenetic, will present at the April 2020 Virtual Investor Summit on Wednesday, April 22nd, 2020 at 11:30 AM ET (Press release, Xenetic Biosciences, APR 15, 2020, View Source [SID1234556366]).

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A live audio webcast of the presentation will be available on the IR Calendar page of the Investors section of the Company’s website (xeneticbio.com). Immediately following the presentation, management will participate in an interactive Q&A session with interested parties, allowing participants to type in questions and receive live responses. A webcast replay will be available two hours following the live presentation and will be accessible for one year.

To schedule a one-on-one call with management, please contact the conference at [email protected] and for more information, please visit virtualinvestorsummit.com.

About Virtual Investor Summit

The Virtual Investor Summit is an online platform that offers both public and private companies, across multiple industries the ability to stay active and engaged with the investment community. Our inaugural summit on April 22-23, 2020 will feature company webcast presentations followed by a virtual, interactive Q&A session, allowing participants to type in questions and receive live responses. Interested participants also have the ability to request one-on-one calls with a featured company. For more information, please visit virtualinvestorsummit.com.

On April 15, 2020 Nanjing Kati Medical Technology Co., Ltd. (hereinafter referred to as Kati Medical) and Nanjing Shenghe Pharmaceutical Co., Ltd. (hereinafter referred to as Shenghe Pharmaceutical) signed a strategic cooperation agreement in the Medical Valley of Jiangbei New District, Nanjing. Wang Enxiu, chairman of Kati Medical, and Zhao Liwen, deputy general manager and director of the research institute of Shenghe Pharmaceutical, signed a strategic cooperation agreement on behalf of both companies. Luo Shuqin, deputy director of the Life and Health Office of Nanjing Jiangbei New District, witnessed the signing (Press release, CART Medical, APR 15, 2020, View Source [SID1234639851]).

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This signing is the beginning of cooperation between the two parties. In the future, the two parties will use this as a starting point to gradually upgrade the level of strategic cooperation and achieve win-win development.

Shenghe Pharmaceutical cherishes this opportunity to cooperate with Kati Medical and believes that through this cooperation, it will promote the rapid development of tumor immunotherapy technology.

Nanjing Biomedicine Valley relies on the national major new drug creation and major scientific and technological achievement transfer pilot demonstration bases to forge ahead and strive to be the source of innovation in the pharmaceutical field. It now includes Kati Medical, Simcere TECO, Luye Pharmaceutical, Nanwei Medical, Jianyou Biochemistry, etc.

There are more than 800 companies related to the comprehensive health industry chain. It is hoped that through the strategic cooperation between Kati Medical and Shenghe Pharmaceutical, the continuous innovation of CAR-T treatment technology will be promoted; with the smooth development of the strategic cooperation between the two parties, more people will enjoy the joy of health in the future.

Through this strategic cooperation, the two parties will achieve complementary advantages and strong alliances to jointly build a new chapter in the development of tumor immunotherapy technology!

On April 15, 2020 TScan Therapeutics, a biopharmaceutical company focused on the development of T cell receptor (TCR) therapies which reprogram a patient’s own T cells to recognize shared cancer targets, reported an agreement with Novartis to discover and develop novel TCR-engineered T cell therapies (Press release, TScan Therapeutics, APR 15, 2020, View Source [SID1234556330]). The collaboration includes an upfront technology access fee and research funding totaling $30 million, and potential milestone payments contingent on clinical, regulatory and sales success that could aggregate in the hundreds of millions of dollars. The collaboration will leverage TScan’s proprietary platform to discover novel cancer antigens that may be targeted by TCR-based therapies.

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"As one of the only companies able to efficiently discover novel cancer antigens that can be targeted with TCR-based therapies, we are delighted to be collaborating with Novartis to develop important TCR treatments," said David P. Southwell, President and Chief Executive Officer, TScan. "We see expansive potential for our platform and this collaboration gives us the opportunity to work with Novartis to develop novel TCR therapies, while at the same time preserving our ability to develop our own proprietary pipeline in both liquid and solid tumors."

Under the agreement, TScan will identify and characterize TCRs, and Novartis will have the option to license and develop TCRs for up to three novel targets. Novartis will also have rights of first negotiation for additional targets and TCRs that arise from the collaboration. In addition to the milestones, Novartis will pay TScan mid-single to low double-digit royalties on net sales for each product. TScan is free to develop TCRs against targets not licensed by Novartis.

"Novartis is a proven leader in the area of T cell therapy, and this collaboration helps us move rapidly and effectively toward our goal of delivering life-changing therapies to patients," added Gavin MacBeath, Chief Scientific Officer, TScan.

On April 15, 2020 Y-mAbs Therapeutics, Inc. (the "Company" or "Y-mAbs") (Nasdaq: YMAB) a late-stage clinical biopharmaceutical company focused on the development and commercialization of novel, antibody-based therapeutic products for the treatment of cancer, reported that it has entered into an agreement with Memorial Sloan Kettering Cancer Center ("MSK") and Massachusetts Institute of Technology ("MIT") for a worldwide exclusive license and research collaboration to develop and commercialize antibody constructs based on the SADA-BiDE (2-step Self-Assembly and DisAssembly-Bispecific DOTA-Engaging antibody system) Pre-targeted Radioimmunotherapy Platform (the "SADA technology"), a concept also referred to as Liquid RadiationTM (Press release, Y-mAbs Therapeutics, APR 15, 2020, View Source [SID1234556349]).

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The SADA technology utilizes a targeted payload delivery method where antibody constructs assemble in tetramers and bind to the tumor target. Unbound constructs predictably disassemble into smaller antibody fragments and are excreted through the kidneys within hours after administration. In a second infusion, a radioactive payload binds to the antibody constructs to radiate the tumor. The SADA technology was invented by Nai-Kong V. Cheung, M.D., Ph.D., Mahiuddin Ahmed, Ph.D. and Brian Santich, Ph.D. and adapted for radioimmunotherapy by Steven M. Larson, M.D. and Sarah Cheal, Ph.D., all current or former MSK employees.

Under the license, Y-mAbs will initiate development of a number of constructs developed by MSK and will advance a series of the Company’s proprietary constructs. The SADA technology will also be available for sublicensing.

"I am excited to enter into this agreement with MSK and MIT to expand Y-mAbs’ antibody platform with this promising technology. We believe the SADA technology represents a new approach to pre-targeted radioimmunotherapy, which may have the potential to improve the current treatment landscape, since it enhances the therapeutic index of payload delivery," stated Thomas Gad, Founder, Chairman, President and Head of Business Development and Strategy.

Dr. Claus Moller, Chief Executive Officer, continued, "We believe the SADA technology takes radioconjugated antibody constructs to a new level and opens a much broader usage than any other radiolabeling technology in the antibody area. The pre-targeted approach means that we expect to deliver higher doses of radiation directly to the tumor while minimizing the exposure to normal tissues. I don’t believe the tumor-to-blood standard uptake ratios obtained in animal models based on the SADA technology have ever been seen before."

On April 15, 2020 AIkido Pharma Inc. (AIKI) ("AIkido" or the "Company"), a technology development company committed to the fostering of innovative ideas, reported the closing of its previously announced registered direct offering with several institutional and accredited investors of 14,000,000 shares of its common stock at a purchase price of $1.00 per share, priced at-the-market under Nasdaq rules (Press release, Spherix, APR 15, 2020, View Source [SID1234556350]). The gross proceeds to the Company from the offering totaled $14.0 million, before deducting placement agent fees and other offering expenses.

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H.C. Wainwright & Co., LLC acted as the exclusive placement agent for the offering.

The Company intends to use the net proceeds from the offering for working capital and general corporate purposes.

The shares of common stock described above were offered by AIkido pursuant to a shelf registration statement on Form S-3 (No. 333-220632), which was previously declared effective by the Securities and Exchange Commission ("SEC"). A final prospectus supplement and the accompanying prospectus relating to the common shares was filed by AIkido with the SEC and can be obtained at the SEC’s website at View Source Electronic copies of the final prospectus supplement and the accompanying prospectus relating to the registered direct offering may also be obtained by contacting H.C. Wainwright & Co., LLC, 430 Park Avenue, New York, New York 10022, by email at [email protected] or by phone at (646) 975-6996.

This press release does not constitute an offer to buy nor will there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.