On February 27, 2020 Ryvu Therapeutics (WSE: RVU), a clinical stage biopharmaceutical company developing novel small molecule therapies that address emerging targets in oncology, reported that data from its multiple oncology programs will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting taking place April 24 to April 29, 2020, in San Diego, CA (Press release, Ryvu Therapeutics, FEB 27, 2020, View Source [SID1234554950]).

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Data presented will include results from the small-molecule STING agonists, dual A2A/A2B adenosine receptors antagonist program, HPK1 inhibitors and SMARCA2 (BRM) degraders program.

Details of the poster presentations are as follows:

Title: In vivo and in vitro characterization of RVU330 best-in-class dual A2A/A2B adenosine receptor antagonist
Session Title: Immunomodulatory Agents and Interventions 2
Session Date and Time: Tuesday, April 28, 2020 1:30 PM – 5:00 PM (PST)
Location: Section 46
Poster Board Number: 15
Permanent Abstract Number: 5555

Title: Development of selective small molecule STING agonists suitable for systemic administration
Session Title: Immunomodulatory Agents and Interventions 1
Session Date and Time: Tuesday, April 28, 2020, 9:00 AM – 12:30 PM (PST)
Location: Poster Section 49
Poster Board Number: 27
Permanent Abstract Number: 4521A

Title: Development and characterization of small molecule HPK1 inhibitors
Session Title: Small Molecule Therapeutic Agents
Session Date and Time: Monday, April 27, 2020 9:00 AM – 12:30 PM (PST)
Location: Poster Section 31
Poster Board Number: 14
Permanent Abstract Number: 1947

Title: Development of novel, selective SMARCA2 (BRM) degraders for treatment of SMARCA4 (BRG1) mutated tumors
Session Category: Molecular and Cellular Biology/Genetics
Session Title: Histone Modifications and Epigenomics
Session Date and Time: Tuesday, April 28, 2020 9:00 AM – 12:30 PM (PST)
Location: Poster Section 9
Poster Board Number: 15
Permanent Abstract Number: 3656

Presentations will be held at the San Diego Convention Center, Exhibit Halls A-F, in respective Poster Sections. Additional information is available at on the AACR (Free AACR Whitepaper) conference website View Source

On February 27, 2020 In honor of Rare Disease Day on February 29th, Incyte (NASDAQ:INCY) is reported the launch of Rare Reflections: MPNs Unmasked, a disease awareness initiative focused on raising awareness of and educating about myeloproliferative neoplasms (MPNs), a group of rare, chronic blood cancers (Press release, Incyte, FEB 27, 2020, View Source [SID1234555965]).

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As part of ongoing efforts to raise awareness of MPNs, Incyte has partnered with J.G. Jones, a renowned comic book artist who was diagnosed with an MPN over a decade ago, to capture the experiences of those impacted by MPNs. Rare Reflections features a series of portraits by Jones who uses graphic art to tell the powerful and personal stories of real patients with MPNs and those impacted by MPNs.

The illustrations can be viewed at www.VoicesofMPN.com/RareReflections, along with more information about Jones’ disease journey and the stories of others living with MPNs.

"Art has the amazing ability to capture the emotions of its subjects beyond the surface, and I am honored to partner with Incyte on Rare Reflections to raise awareness of MPNs by doing the work I love," said Jones. "I know first-hand how living with an MPN can affect many aspects of a person’s life – physically and emotionally – and I hope, through increased awareness and education, to empower others living with an MPN to take control of their journey."

"Rare Disease Day offers a time for patients, caregivers, advocates and healthcare providers to join together to shine a light on the estimated 200,000 individuals in the United States living with an MPN," said Hervé Hoppenot, Chief Executive Officer, Incyte. "Incyte is pleased to partner with a respected illustrator such as J.G. Jones to bring to life the real stories of those living with an MPN and to highlight the unique experiences of people across the MPN community."

In honor of Rare Disease Day, Incyte is also supporting several efforts intended to raise awareness of MPNs and help patients with MPNs find tools and resources to help address the daily challenges they may face:

Ask an MPN Expert Facebook Live: Tune into Voices of MPN’s "Ask an MPN Expert" Facebook Live, where Incyte Oncology Clinical Nurse Educators (OCNEs) will provide educational information about MPNs and answer your MPN-related questions. The Facebook Live Chat will begin tonight, February 27, at 7:00 p.m. ET. Join the conversation here.
Nominate your MPN Hero: Honor the individual or organization in your life who has contributed to the MPN community by going above and beyond to make a real difference. In honor of Rare Disease Day, the nomination period for the 2020 MPN Heroes program opens tomorrow, February 28, and nominations are being accepted through September 12, 2020. To learn more about the program or to submit a nomination, visit www.MPNHeroes.com.
Stay connected and informed about all of the MPN awareness activities by "Liking" the "Voices of MPN" Facebook page, following "Voices of MPN" on Pinterest and following "Voices of MPN" on Twitter.

About Myeloproliferative Neoplasms

Myeloproliferative neoplasms (MPNs) are a closely related group of blood cancers in which the bone marrow functions abnormally. The bone marrow is where the body’s blood cells are made. MPNs are progressive blood cancers that can strike anyone at any age, but they are more common in older adults. Estimates of the prevalence of MPNs vary, but analysis of claims data suggests there may be as many as 200,000 people in the U.S. living with MF, PV or ET.1

On February 27, 2020 PokeAcell, a newly founded immunotherapy company, has secured exclusive licensing rights to a proprietary technology, for personalized T cell therapy (Press release, PokeAcell, FEB 27, 2020, View Source [SID1234596101]). The new technology can activate and grow cancer-specific T cells present in patient’s own blood and the cells can then be given back to the patient as fully personalized treatment. The T cell therapy hold the potential of curative treatment in Metastatic Melanoma and Merkel Cell carcinoma – two of the most severe skin cancers today and with potential in several other indications.

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"We are founding PokeAcell with the mission to provide curative treatment to solid tumor patients with no available treatment today. We are pleased to sign this exclusive licensing agreement with DTU on the ImmPACT activation technology and further strengthen the development of personalized T cell therapy," says Anne Reker Cordt, CEO and co-founder PokeAcell

PokeAcell is a spin out of DTU Health Technologies based on the distinct expertise of Prof. Sine R. Hadrup, PhD., who will receive the prestigious Elite Research Prize from the Ministry of Higher Education and Science at a ceremony later today.

Prof. Sine R. Hadrup – inventor and co-founder of PokeAcell, says: "T cells are the natural soldiers of the immune system and hold immense potential in the treatment of cancer. The ImmPACT technology create a personalized cell product with very beneficial properties and is now one step closer to helping patients in need of better treatment".

PokeAcell is founded by an experienced team of science and business leaders and have established a strong advisory Board, which includes profiles such as John Haurum, biotech executive and board member and Inge Marie Svane, Prof, MD Herlev CCIT.

"In patients with metastatic cancers it can be very difficult for the immune system to overcome the influence of the cancer. T cell therapy has shown good results in clinical trials and PokeAcell’s T cell technology has a very interesting potential for extending T cell therapy to more patients with Metastatic Melanoma. I look forward to the results of the first clinical evaluation," says Inge Marie Svane, Prof, MD Herlev CCIT.

PokeAcells is a Copenhagen based privately owned immunotherapy company. PokeAcell’s personalized T cell product is in pre-clinical evaluation and is in preparation for an investigator lead phase I in Metastatic Melanoma at Herlev CCIT.

On February 27, 2020 Xenetic Biosciences, Inc. (NASDAQ:XBIO) ("Xenetic" or the "Company"), a biopharmaceutical company focused on advancing XCART, a personalized CAR T platform technology engineered to target patient- and tumor-specific neoantigens, reported that the webcast replay from the presentation given by Jeffrey Eisenberg, Chief Executive Officer of Xenetic, at NobleCon16 – Noble Capital Markets’ 16th Annual Investor Conference is now available (Press release, Xenetic Biosciences, FEB 27, 2020, View Source [SID1234554872]).

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The high-definition, video webcast of the Company’s presentation is accessible here, and as part of a complete catalog of presentations available at Noble Capital Markets’ Conference website: www.nobleconference.com and on Channelchek www.channelchek.com, the investor portal created by Noble. The webcast will be archived on the Company’s website, the NobleCon website and on the Channelchek website for 90 days.

On February 27, 2020 Harbour BioMed (HBM) reported U.S. Food and Drug Administration (FDA) approval of its Investigational New Drug (IND) application for a Phase 2 clinical trial of HBM9167, its humanized IgG1 monoclonal antibody targeting programmed death-ligand 1 (PD-L1), for the treatment of nasopharyngeal cancer (NPC) (Press release, Harbour BioMed, FEB 27, 2020, View Source [SID1234554899]). Separately, the Agency’s Office of Orphan Products Development granted HBM9167 Orphan Drug Designation (ODD) for the use in treating NPC.

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"Nasopharyngeal cancer is a tumor type for which patients remain in need of effective treatment options," said Dr. Jingsong Wang, Founder, Chairman and CEO of Harbour BioMed. "The Orphan Drug Designation for HBM9167 will provide an accelerated development path for HBM9167. In addition, we were also able to work with the FDA to enable a direct entry into a Phase 2 clinical study in patients with metastatic or recurrent disease."

HBM9167 has been evaluated by HBM’s partner Kelun-Biotech in China in studies involving more than 300 subjects to date. These trials include Phase 1 and ongoing Phase 2 trials in multiple cancer types, including NPC and classical Hodgkin’s Lymphoma. Preliminary results from these ongoing trials have shown a tolerable safety profile in patients.

The FDA grants ODD status to drugs intended for the treatment, diagnosis or prevention of rare diseases or disorders that affect fewer than 200,000 people in the U.S. ODD qualifies a drug sponsor for various development incentives under the Orphan Drug Act, such as eligibility for a seven-year period of market exclusivity following regulatory approval, clinical trial assistance and a 50 percent tax credit on the cost of clinical trials conducted in the U.S.

About HBM9167
HBM9167 is a humanized IgG1 monoclonal antibody (mAb) directed against human programmed death-ligand 1 (PD-L1). Through binding with PD-L1, HBM9167 blocks its interaction with programmed cell death protein 1 (PD-1), thereby releasing the PD-L1/PD-1 mediated inhibition on immune response, and subsequently restoring the cytotoxic immune function of T-cells to enhance anti-tumor immunity. Monoclonal antibodies that target PD-1 or PD-L1 can inhibit their binding activity, maintain the function of effector T-cells to prevent cancer cells from escaping the immune surveillance, and thus maintain the body’s immune ability against cancer cells. Harbour BioMed in-licensed HBM9167 from Kelun-Biotech with the right to develop and commercialize it worldwide, excluding Greater China.