On December 4, 2019 COTA, Inc., a healthcare technology company that uses real-world data (RWD) to bring clarity to cancer care, reported is presenting posters at the American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting & Exposition, ASH (Free ASH Whitepaper) 2019, in Orlando, FL from December 7-10, 2019 (Press release, COTA, DEC 4, 2019, https://www.prnewswire.com/news-releases/cota-presents-posters-at-ash-annual-meeting-reviewing-complexities-of-generating-rwd-and-how-it-complements-traditional-clinical-trial-data-300969065.html [SID1234551947]). Collectively, the posters review existing challenges for generating RWD and the promise of this data to support new research in cancer biology.
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"The genetic environment – whether of individual patients or cancer cells – is playing an increasing role in how patients are being treated. Examining sources of real-world data in depth allows us to quickly, inexpensively test hypotheses related to the treatment of patients with specific biomarkers and their outcomes," said Andrew Norden, MD, Chief Medical Officer at COTA.
The Unforeseen Medical and Business Challenges Found When Integrating Abstracted Data from Disparate EHR Systems While Building the Curecloud Direct-to-Patient Multiple Myeloma Registry
Researchers from COTA and Multiple Myeloma Research Foundation (MMRF) explore challenges associated with existing methods of patient data curation to build the MMRF Registry. Despite a significant investment in electronic health records in the United States, many institutions are unable to provide relevant, research-grade clinical data in a timely, cost-free, and coded manner. A comprehensive, research-focused data abstraction process for coded data exchange is being established to support future RWD projects.
Chromosome 1q Amplification Is Associated with a History of Prior Malignancies Among Patients Newly Diagnosed with Multiple Myeloma
Researchers from COTA and Hackensack University Medical Center studied patients with newly diagnosed multiple myeloma who also had a history of prior malignancy. Using COTA’s RWD, they were able to identify an association with a prior history of cancer, especially prostate cancer, and amp(1q) in multiple myeloma. This relationship is worth further exploration of whether there is a common pathway associated with these characteristics. These findings are significant because patients with prior malignancies are often excluded from enrollment in clinical trials and rarely studied. Overall, the results reported suggest that RWD is an efficient and comparatively inexpensive tool to support research in cancer biology.
Thanks to a growing understanding and acceptance of RWD by regulatory bodies, it has been increasingly incorporated into clinical research, helping to expedite studies compared with traditional clinical trial methods alone. Rather than replacing clinical trials, these two models can complement each other to improve clinical trial design and postmarket research, allowing for a more complete picture of the patient group being studied.
Members of COTA’s Life Sciences team will be at ASH (Free ASH Whitepaper) to discuss their work with the Multiple Myeloma Research Foundation (MMRF) and Hackensack University Medical Center (HUMC). Contact [email protected] to set up a meeting to learn more about how RWD can accelerate clinical research and ultimately reduce the cost of clinical trials.
The two posters will be exhibited in Hall B, Level 2 on Monday, December 9, 2019, 6:00 PM – 8:00 PM and Saturday, December 7, 2019, 5:30 PM-7:30 PM.