Termination of a Material Definitive Agreement.

On December 19, 2018 On December 19, 2018, BeiGene, Ltd. (the "Company") reported that it received notice from Merck KGaA ("Merck KGaA") that Merck KGaA was terminating for convenience the parties’ License Agreement dated December 10, 2013, as amended, for the Company’s investigational RAF dimer inhibitor lifirafenib (BGB-283) in the People’s Republic of China ("PRC") (Filing, 8-K, BeiGene, DEC 19, 2018, View Source [SID1234532301]). As a result of such termination, Merck KGaA’s exclusive right of first negotiation to acquire exclusive commercialization rights under the lifirafenib RAF dimer program in the PRC was terminated and the Company is no longer required to pay Merck KGaA royalties on sales of lifirafenib in the PRC or entitled to receive future milestone payments from Merck KGaA for lifirafenib. The Company’s ex-PRC agreement with Merck KGaA on lifirafenib was terminated in March 2017.

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Compass Therapeutics Expands Leadership Team with Appointments of Chief Medical Officer and Chief Financial Officer

On December 19, 2018 Compass Therapeutics, a biotechnology company committed to the ambitious goal of comprehensively drugging the human immune system, reported the appointment of veteran biopharma leaders Yu Liu, M.D., Ph.D., MBA, as chief medical officer and Lynne Sullivan as chief financial officer (Press release, Compass Therapeutics, DEC 19, 2018, View Source [SID1234532145]).

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Dr. Liu, who most recently served as vice president and head of early clinical development at Pfizer, will oversee Compass’ development of a deep pipeline of immuno-oncology and autoimmune disease candidates. The company’s lead candidate, CTX-471, a fully human monoclonal antibody that induces remodeling of the tumor microenvironment and leads to immune-mediated destruction of solid tumors, is expected to enter the clinic in the first quarter of 2019. More than 15 therapeutic candidates are advancing through preclinical development and the research team continues to generate an exciting array of novel candidates through the company’s proprietary antibody development platform.

Ms. Sullivan, who most recently served as senior vice president, finance at Biogen, will lead financial planning and management at Compass at a time of significant growth for the company.

"Yu and Lynne bring essential skills and expertise to Compass as we prepare to take our lead program into the clinic in the coming months," said Thomas Schuetz, M.D., Ph.D., the company’s co-founder and chief executive officer. "Their depth of experience and the strength of their leadership will serve us well, and we’re excited to welcome them aboard."

At Pfizer, Dr. Liu oversaw early clinical development of the company’s pipeline candidates in internal medicine, rare disease and inflammation/ immunology. Prior to Pfizer, Dr. Liu led Biogen’s early clinical development effort in rare disease, with an emphasis on cell and gene therapy. Earlier, he held various leadership roles at Bristol-Myers Squibb, culminating in his position as vice president of the oncology business unit, based in Shanghai, China. Previously Dr. Liu held positions at Essentialis Therapeutics and Amgen. Dr. Liu trained in internal medicine at Massachusetts General Hospital. He received his Ph.D. in immunology from Boston University and his MBA in finance from University of Massachusetts, Boston. He also completed a residency scholarship program in clinical research at the Harvard School of Public Health.

At Biogen, Ms. Sullivan moved through positions of increasing responsibility during her more than 10-year tenure and was named senior vice president of finance in 2015. In that role, she led financial planning and analysis, corporate finance and tax functions for Biogen’s global operations. Prior to Biogen, Ms. Sullivan served as a vice president overseeing tax function for Merck KGaA’s North American operationsand was Serono’s Vice President, Tax, Americas and International for seven years. She was a Tax Partner in the Boston office of Arthur Andersen prior to joining Serono. She currently serves as director and chair of the audit committee for both resTORbio and Solid Biosciences. Ms. Sullivan earned a bachelor’s degree in accounting from Suffolk University and a master’s in taxation from Bentley University. She is also a CPA in Massachusetts.

Jazz Pharmaceuticals to Present at the J.P. Morgan Healthcare Conference on January 7

On December 19, 2018 Jazz Pharmaceuticals plc (Nasdaq: JAZZ) reported that the company will be webcasting its corporate presentation at the 37th Annual J.P. Morgan Healthcare Conference in San Francisco, CA (Press release, Jazz Pharmaceuticals, DEC 19, 2018, View Source [SID1234532162]).

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Bruce Cozadd, chairman and chief executive officer, will provide an overview of the company and a business and financial update at the conference on Monday, January 7, 2019 at 10:30 a.m. PST / 6:30 p.m. GMT.

A live audio webcast of the presentation may be accessed from the Investors section of the Jazz Pharmaceuticals website at View Source Please connect to the website prior to the start of the presentation to ensure adequate time for any software downloads that may be necessary to listen to the webcast.

An archive of the webcast will be available for at least one week following the presentation on the Investors section of the company’s website at View Source

Varian to Present at the J.P. Morgan Healthcare Conference

On December 19, 2018 Varian (NYSE: VAR) reported that Dow Wilson, chief executive officer, and Chris Toth, president of Oncology Systems, will present at the J.P. Morgan Healthcare Conference in San Francisco, scheduled for 9:30 a.m. Pacific Time on January 7, 2019 (Press release, Varian Medical Systems, DEC 19, 2018, View Source [SID1234532163]).

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Information about the webcast of the company’s presentation will be available through a link on the company website at www.varian.com/inv­estors.

Applied DNA Announces Proposed Public Offering of Common Stock and Warrants

On December 19, 2018 Applied DNA Sciences, Inc. (Nasdaq: APDN) ("Applied DNA" or the "Company"), a leader in large-scale PCR-based DNA manufacturing, reported that it intends to offer for sale a combination of shares of its common stock and warrants to purchase shares of its common stock in an underwritten public offering (Press release, Applied DNA Sciences, DEC 19, 2018, View Source [SID1234532183]). The Company intends to use the net proceeds from this offering for working capital, capital expenditures, business development and research and development expenditures. The offering is subject to market conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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Maxim Group LLC is acting as sole underwriter and book-running manager for the offering.

The securities described above are being offered under the Company’s shelf registration statement on Form S-3 (No. 333-218158), previously filed with and declared effective by the U.S. Securities and Exchange Commission (SEC). The securities will be offered by means of a prospectus supplement and accompanying prospectus, forming a part of the effective registration statement. The prospectus supplement and accompanying prospectus related to the offering will be filed with the SEC and will be available on the website of the SEC at View Source Electronic copies of the prospectus supplement and accompanying prospectus also may be obtained from Maxim Group LLC, 405 Lexington Avenue, 2nd Floor, New York, NY 10174, at 212-895-3745. Before you invest, you should read the prospectus supplement and the accompanying prospectus in the registration statement and other documents Applied DNA has filed or will file with the SEC for more complete information about Applied DNA and the offering.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any offer or sale of these securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such jurisdiction.