On November 18, 2019 Heat Biologics, Inc. (NASDAQ:HTBX), a biopharmaceutical company developing immunotherapies designed to activate a patient’s immune system against cancer, reported that top line data from its ongoing Phase 2 trial of HS-110 will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Special Conference on Tumor Immunology and Immunotherapy (Press release, Heat Biologics, NOV 18, 2019, View Source [SID1234551408]).

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The poster, titled "Viagenpumatucel-L (HS-110) plus nivolumab in previously-treated patients with advanced non-small cell lung cancer (NSCLC)," will be presented starting at 4:30PM Eastern Time on November 19, 2019.

The AACR (Free AACR Whitepaper) Special Conference on Tumor Immunology and Immunotherapy is being held at the Boston Marriott Copley Place in Boston on November 17-20, 2019.

About AACR (Free AACR Whitepaper) Special Conference on Tumor Immunology

The AACR (Free AACR Whitepaper) Special Conference on Tumor Immunology and Immunotherapy is designed to integrate multidisciplinary facets of basic cancer immunology and immunotherapy to broaden our understanding of ways to harness the immune system to treat cancer. The hallmark of this series is also to encourage the effective exchange of ideas between basic cancer immunologists, nonimmunologists, and clinical oncologists in order to develop approaches that translate to outcomes. This year’s program will feature international leaders in the field, who will expand our knowledge of the microbiome, adverse immunologic events, imaging and other new technologies, genetics and epigenomics of immuno-oncology, and immunologic signaling pathways. These world-renowned oncologists and researchers will offer their insights on novel cell therapies, biomarkers, vaccines, and adjuvants, all in the pursuit of understanding tumor evolution and creating better treatments.

On November 18, 2019 ProMIS Neurosciences, Inc. (TSX: PMN) (OTCQB: ARFXF), a biotechnology company focused on the discovery and development of antibody therapeutics targeting toxic oligomers implicated in the development of neurodegenerative diseases, is reported that, further to its news release dated November 13, 2019, it completed on November 15, 2019, the first closing of its private placement of up to $6.5M (Press release, ProMIS Neurosciences, NOV 18, 2019, View Source [SID1234551424]). In the first closing, the Company issued 10,276,666 Units for gross proceeds of approximately CDN$2,055,333.

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"We are pleased to announce this first closing and given the interest expressed look forward to the final closing in the coming weeks," stated Dr. Elliot Goldstein, ProMIS President and CEO.

Each Unit issued in the first closing consisted of one common share of the Company and one share purchase warrant of the Company. Each warrant entitles the holder thereof to purchase one share at an exercise price of $0.35 per share at any time for five years. The Company also issued 162,400 finders warrants having the same terms as the unit warrants.

All securities issued in connection with the Offering are subject to a four-month statutory hold period in accordance with applicable provincial securities laws. Net proceeds from the offering are intended to be used to advance the company’s antibody therapeutic candidates selectively targeting toxic oligomers implicated in neurodegenerative diseases, for working capital and general corporate purposes.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy nor shall there be any sale of the securities in any state in which such offer, solicitation or sale would be unlawful. The securities issued, or to be issued, under the Offering have not been, and will not be, registered under the United States Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.

On November 18, 2019 Medicenna Therapeutics Corp. ("Medicenna" or "the Company") (TSX: MDNA,OTCQB: MDNAF), a clinical stage immuno-oncology company, reported that it will host a lunchtime seminar led by key opinion leaders ("KOL"’s) to highlight the current treatment options for recurrent glioblastoma ("rGBM") and the clinical benefits seen with MDNA55, an IL4 receptor targeted therapy in this setting (Press release, Medicenna Therapeutics, NOV 18, 2019, View Source [SID1234551440]). In addition to the Principal Investigators of the recently completed Phase 2b clinical trial, Dr. John Sampson and Dr. Santosh Kesari, the co-inventor of MDNA55 Dr. Raj Puri, will also participate in the symposium. The event will take place during the Society for Neuro-Oncology ("SNO") annual meeting being held at the JW Marriott Desert Ridge Resort at 5350 E. Marriott Drive in Phoenix, AZ.

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The symposium is scheduled for Friday, November 22 from 12:15 to 1:15 PM MT in the Grand Sonoran Room G and will feature presentations as follows:

Raj Puri, MD, PhD – Director, Division of Cellular and Gene Therapies, Center for Biologics Evaluation and Research, FDA.

John H. Sampson, MD, PhD, MHSc, MBA – Robert H. and Gloria Wilkins Distinguished Professor and Chair of Neurosurgery, Department of Neurosurgery, Duke University School of Medicine

Santosh Kesari, MD, PhD – Director, Neuro-oncology, Pacific Neuroscience Institute; Chair and Professor, Department of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute
The panel will discuss the current unmet medical need for treating individuals with rGBM, the most common and uniformly fatal form of brain cancer, and the potential for an IL4 receptor targeted therapy to combat this disease. The presentation will also highlight key safety and efficacy data from the MDNA55 Phase 2b clinical trial and the positive outcomes seen in patients enrolled in this study.

For information on this event, please send an email request to [email protected].

Medicenna intends to follow this event with a KOL call for investors, analysts and business development professionals. Further information on this event and the KOL call will be released as soon as available.

On November 18, 2019 LabCorp (NYSE: LH) reported that it has priced its offering of $1,050,000,000 in senior notes (Press release, LabCorp, NOV 18, 2019, View Source [SID1234552830]). The offering consists of two tranches: $400,000,000 aggregate principal amount of 2.300% Senior Notes due 2024 (the 2024 Notes) and $650,000,000 aggregate principal amount of 2.950% Senior Notes due 2029 (the 2029 Notes and, together with the 2024 Notes, the Notes). The Notes will bear interest from Nov. 25, 2019, payable semi-annually on June 1 and Dec. 1, commencing on June 1, 2020. The closing of the offering is expected to occur on Nov. 25, 2019, subject to the satisfaction of customary closing conditions. The Notes will be senior unsecured obligations and will rank equally with LabCorp’s existing and future senior unsecured debt. Concurrently with this offering, LabCorp is conducting a cash tender offer for up to $300,000,000 aggregate purchase price of its 4.625% Senior Notes due Nov. 15, 2020 (the Tender Offer).

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LabCorp intends to use the net proceeds of the Notes offering for general corporate purposes including (1) the purchase, redemption or repayment at maturity of its outstanding 2.625% Senior Notes due Feb. 1, 2020, (2) the concurrent Tender Offer, and (3) the repayment of some or all of the amounts outstanding under its term loan credit facilities.

The joint book-running managers for the offering are BofA Securities, US Bancorp, and Wells Fargo Securities. The offering will be made pursuant to an effective shelf registration statement on Form S-3 filed with the Securities and Exchange Commission. A copy of the prospectus and related prospectus supplement may be obtained without charge from the Securities and Exchange Commission. Alternatively, a copy of the prospectus and related prospectus supplement may be obtained from BofA Securities by calling toll-free 1-800-294-1322, from US Bancorp by calling toll-free 1-877-558-2607, or from Wells Fargo Securities by calling toll-free 1-800-645-3751.

This press release does not constitute an offer to sell or a solicitation of an offer to buy the Notes or any other securities, nor shall there be any sale of these securities in any jurisdiction in which such an offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction. The offering of these securities may be made only by means of the prospectus supplement and the accompanying prospectus.

On November 18, 2019 Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a biotechnology company developing the next generation of immuno-oncology therapeutics based on its proprietary self-delivering RNAi (INTASYL) therapeutic platform, reported the pricing of its previously announced public offering of 10,000,000 shares of its common stock, at a public offering price per share of $0.10, for gross proceeds of $1.0 million, before deducting placement agent fees and other offering expenses (Press release, Phio Pharmaceuticals, NOV 18, 2019, View Source [SID1234551409]). The offering is expected to close on or about November 19, 2019, subject to the satisfaction of customary closing conditions.

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H.C. Wainwright & Co. is acting as exclusive placement agent for the offering.

Phio intends to use the net proceeds from this offering to fund the development of its immuno-oncology programs, for other research and development activities and for general working capital needs.

The shares of common stock described above were offered by Phio pursuant to a shelf registration statement on Form S-3 (File No. 333-224031) filed with the Securities and Exchange Commission (the "SEC") on March 29, 2018 and declared effective by the SEC on April 6, 2018. A preliminary prospectus supplement and accompanying prospectus related to the offering was filed with the SEC. The final terms of the offering will be disclosed in a final prospectus supplement to be filed with the SEC. When available, electronic copies of the final prospectus supplement and accompanying prospectus may be obtained by contacting H.C. Wainwright & Co., LLC, 430 Park Avenue, 3rd Floor, New York, New York 10022, via e-mail at [email protected] or via telephone at (646) 975-6996.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy any securities described herein, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.