Atara Biotherapeutics Appoints Pascal Touchon President, Chief Executive Officer and Member of the Board of Directors

On May 28, 2019 Atara Biotherapeutics, Inc. (Nasdaq: ATRA), a leading off-the-shelf, allogeneic T-cell immunotherapy company developing novel treatments for patients with cancer, autoimmune and viral diseases, reported the appointment of Pascal Touchon as President, Chief Executive Officer and member of the Board of Directors (Press release, Atara Biotherapeutics, MAY 28, 2019, View Source [SID1234536625]).

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Dr. Touchon has over 30 years of global biopharmaceutical leadership experience, most recently at Novartis Oncology serving as Global Head, Cell & Gene and member of the Oncology Executive Committee. Notably in this role he was accountable for the Oncology Cell & Gene unit financial performance and responsible for all activities including the global launch of KYMRIAH (tisagenlecleucel), securing regulatory approval and reimbursement in major markets, expanding global CAR T manufacturing and technical operations, overseeing multiple new clinical studies and building a strong leadership team.

Previously at Novartis, Pascal Touchon served as Global Head, Strategy, Business Development, Oncology where he was responsible for various activities including early commercial strategy, portfolio management, business development and external collaborations as well as member of the Oncology Executive Committee. Prior to joining Novartis Oncology, Dr. Touchon held leadership roles in research, marketing, general management and business development at various companies including Servier, Sanofi, Glaxo and Glaxo-Wellcome.

"We are delighted that Pascal Touchon will be Atara’s next Chief Executive Officer," said Carol G. Gallagher, Pharm.D., Atara’s Lead Independent Director. "His proven oncology leadership as well as CAR T development and global commercialization experience make him an ideal choice to lead Atara. We are confident that Pascal’s capability to unite cell and gene immunotherapy teams will help to guide strategy and execution in the years ahead and enable Atara to further realize its mission to transform the lives of patients with serious diseases."

In connection with Dr. Touchon’s appointment, Isaac Ciechanover stepped down from his role as President, Chief Executive Officer and member of the Board of Directors, effective today. Dr. Ciechanover will serve as a special advisor to a subcommittee of the Board who will lead the Company until Dr. Touchon begins his tenure as President, Chief Executive Officer and member of the Board of Directors on June 24, 2019.

"When I announced my decision to step down in January, I had agreed to stay on until my successor was chosen," said Isaac Ciechanover M.D. "I am thrilled with the appointment of Pascal, who I know will lead the company in its next stages of growth."

"Isaac has been the inspiration and architect of Atara since its founding nearly seven years ago," added Dr. Gallagher. "We thank him for his leadership and vision building a world-class T-cell and CAR T immunotherapy company. We wish him the very best in his next endeavor."

In addition, Dr. Dietmar Berger, Atara’s Global Head of Research and Development, has resigned from the Company effective as of May 31, 2019 to pursue other opportunities.

Onconova Therapeutics Announces Presentations At Three Upcoming Conferences

On May 28, 2019 Onconova Therapeutics, Inc. (NASDAQ:ONTX), a Phase 3-stage biopharmaceutical company focused on discovering and developing novel products to treat cancer, with an initial focus on myelodysplastic syndromes (MDS), reported that it will be presenting at three upcoming conferences (Press release, Onconova, MAY 28, 2019, View Source [SID1234536608]):

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Acute Leukemia Forum China May 31 – Shanghai
Presentation: Fri, May 31 Steven Fruchtman, MD, President & CEO

BIO International Forum, Philadelphia June 3-6 – Philadelphia, PA
Presentation: Tues, June 4 3:15p EDT Steven Fruchtman, President & CEO
Webcast: http://www.veracast.com/webcasts/bio/internationalconvention2019/74119246905.cfm
Avi Oler, VP Corporate Development, will also attend and be available to meet with interested parties

9th Annual LD Micro Invitational June 4-5 – Bel Air, CA
Presentation: Tues, June 4 8:20a PDT Mark Guerin, CFO

Galectin Therapeutics Raises $44.5 Million in Rights Offering and $2.5 Million From Warrant Exercise

On May 28, 2019 Galectin Therapeutics Inc. (NASDAQ: GALT), the leading developer of therapeutics that target galectin proteins, reported its Rights Offering has closed (Press release, Galectin Therapeutics, MAY 28, 2019, View Source [SID1234536626]).

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The Rights Offering resulted in the issuance of approximately 10.4 million shares of the Company’s common stock at a price of $4.28 per share, for total gross proceeds of $44.5 million to the Company. Investors in the Rights Offering also received warrants for the purchase of approximately 2.6 million shares of the Company’s common stock with an exercise price of $7.00 per share, which expire seven years after issuance. After giving effect to the rights offering, the Company has approximately 56 million shares of common stock issued and outstanding.

Richard E. Uihlein, Chairman of the Board of Directors, subscribed for $20,033,000 in the Rights Offering. Mr. Uihlein stated, "We are pleased with the results of the Rights Offering and are gratified that so many of our stockholders responded by making further investments in our Company. From the outset, we wanted to turn first to our stockholder base and give them the opportunity to continue supporting our company, its development program, and its clinical trials; we are proud that so many did so, with investments large and small. This capital raise positions us to proceed with plans to initiate a Phase 3 clinical trial this fall in patients with NASH cirrhosis."

Separately, Mr. Uihlein also exercised 500,000 common stock warrants at an exercise price of $5.00 per share for proceeds of $2,500,000.

A registration statement relating to the shares of common stock in the Rights Offering was previously filed with the Securities and Exchange Commission (the "SEC") and declared effective on April 12, 2019. Subscription rights that were not exercised by 5:00 p.m. Eastern Time on May 23, 2019, have expired.

Corcept Therapeutics to Present Data from Phase 1/2 Trial of Relacorilant Plus Nab-Paclitaxel in Patients with Solid Tumors at the American Society of Clinical Oncology Annual Meeting

On May 28, 2019 Corcept Therapeutics Incorporated (NASDAQ: CORT), a commercial-stage company engaged in the discovery and development of drugs that treat severe metabolic, oncologic and psychiatric disorders by modulating the effects of cortisol, reported that it will present data from the Phase 1/2 study of its proprietary, selective cortisol modulator, relacorilant, in combination with nab-paclitaxel (Abraxane) in patients with solid tumors, at the 2019 annual meeting of the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) in Chicago, Illinois (May 31 – June 4) (Press release, Corcept Therapeutics, MAY 28, 2019, https://ir.corcept.com/news-releases/news-release-details/corcept-therapeutics-present-data-phase-12-trial-relacorilant [SID1234536593]).

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"Our Phase 1/2 trial of relacorilant in combination with nab-paclitaxel has been productive," said Andreas Grauer, MD, Corcept’s Chief Medical Officer. "Encouraging results in patients with platinum-resistant ovarian cancer prompted us, after consultation with our investigators, to initiate a 180-patient, controlled Phase 2 trial of relacorilant plus nab-paclitaxel in that indication earlier this year. We look forward to sharing additional data in patients with a variety of solid tumors."

Monday, June 3rd
Relacorilant (RELA) with nab-paclitaxel (NP): Safety and
activity in patients with pancreatic ductal adenocarcinoma
(PDAC) and ovarian cancer (OvCA)

P. Munster; S. Shepard Gastrointestinal (Noncolorectal) Cancer
Poster Board: #235
Time: 8:00 – 11:00 am
Location: Hall A

Selective and nonselective GR antagonists in combination
with chemotherapy in ovarian cancer PDX models

J. Veneris; G. Fleming Gynecologic Cancer
Abstract No: e17039

About Relacorilant

Relacorilant is a non-steroidal, selective modulator of the glucocorticoid receptor, one of the two receptors to which cortisol binds. Relacorilant does not bind to the body’s other hormone receptors, including the progesterone receptor. Corcept is studying relacorilant as a potential treatment for a variety of serious disorders. Current trials include a 180-patient, controlled Phase 2 trial of relacorilant combined with nab-paclitaxel in patients with platinum-resistant ovarian cancer and a Phase 3 trial of relacorilant as monotherapy for patients with Cushing’s syndrome. Relacorilant is proprietary to Corcept and is protected by composition of matter and method of use patents through 2037. Relacorilant has received orphan designation in the United States for the treatment of both Cushing’s syndrome and pancreatic cancer.

Pacira BioSciences to Present at the Jefferies 2019 Healthcare Conference

On May 28, 2019 Pacira BioSciences, Inc. (NASDAQ: PCRX) reported that it will participate in an analyst-led fireside chat at the Jefferies 2019 Healthcare Conference at 10:00 AM ET on Tuesday, June 4, 2019 (Press release, Pacira Pharmaceuticals, MAY 28, 2019, View Source [SID1234536609]). Live audio of the event can be accessed by visiting the "Events" page of the company’s website at investor.pacira.com. A replay of the webcast will also be available for two weeks following the event.

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