On April 30, 2019 Tetraphase Pharmaceuticals, Inc. (NASDAQ:TTPH), a biopharmaceutical company focused on developing and commercializing novel tetracyclines to treat serious and life-threatening conditions, reported that senior management will be participating at the SunTrust Robinson Humphrey 5th Annual Life Sciences Summit on Tuesday, May 7, 2019 at the Lotte New York Palace Hotel in New York City (Press release, Tetraphase, APR 30, 2019, View Source [SID1234535623]). Guy Macdonald, President and Chief Executive Officer of Tetraphase, will also present a corporate overview at the UBS Global Healthcare Conference on Monday, May 20, 2019 at 1:30 p.m. ET at the Grant Hyatt Hotel in New York City.

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A live audio webcast of the UBS Global Healthcare Conference presentation will be available on the Company’s website at View Source The archived presentation will be available for 30 days.

On April 30, 2019 Novocure (NASDAQ:NVCR) reported that the International Journal of Radiation Oncology, Biology, Physics, known in the field as the Red Journal, has published the results of an EF-14 post-hoc analysis demonstrating that higher doses of Tumor Treating Fields improved survival in newly diagnosed glioblastoma (GBM) patients (Press release, NovoCure, APR 30, 2019, View Source [SID1234535470]). The Red Journal is the official journal of the American Society for Radiation Oncology. This publication is the first reported analysis demonstrating patient-level dose responses to Tumor Treating Fields.

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"The study provides a definition for Tumor Treating Fields dose and creates a framework for Tumor Treating Fields dosimetry and treatment planning," said Matthew T. Ballo, MD, FACR, Professor and Chair, Department of Radiation Oncology, West Cancer Center & Research Institute in Germantown, Tennessee. "This analysis provides radiation oncologists with a better understanding of the relationship between Tumor Treating Fields dose and survival, and can be used to help optimize outcomes for GBM patients."

The simulation-based, post-hoc analysis included 340 patients from the EF-14 phase 3 pivotal trial, which compared Tumor Treating Fields plus temozolomide versus temozolomide alone for the treatment of newly diagnosed GBM. All EF-14 patients who were on treatment for at least two months and who had MRIs of acceptable quality were included.

The median overall survival and progression free survival were significantly longer when the average dose density in the tumor bed was >0.77 mW/cm3: overall survival (25.2 versus 20.4 months, p=0.003, HR=0.611) and progression free survival (8.5 versus 6.7 months, p=0.02, HR=0.699). For Tumor Treating Fields, dose can be defined as time on therapy times the energy delivered, or cumulative energy.

"With the knowledge gained from this study, we have focused our engineering efforts on evolving our Optune system to improve efficacy and extend survival," said Novocure CEO Asaf Danziger. "We have also developed novel mapping algorithms to optimize treatment planning and are working to incorporate these algorithms into a second generation NovoTAL system. We are excited by the potential of these developments to improve patients’ lives."

On April 30, 2019 Xencor, Inc. (NASDAQ:XNCR), a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of cancer, autoimmune diseases, asthma and allergic diseases, reported the U.S. Food and Drug Administration (FDA) has lifted the partial clinical hold that was placed on the Phase 1 study of XmAb14045, a CD123 x CD3 bispecific antibody molecule being evaluated in patients with relapsed or refractory acute myeloid leukemia and other CD123-expressing hematologic malignancies (Press release, Xencor, APR 30, 2019, View Source [SID1234535471]). The decision follows discussion and agreement with the FDA on amendments to the study protocol, including guidance on the monitoring and clinical management of cytokine release syndrome.

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"We are working with investigational sites to resume enrollment based on the amended protocol, through which we have sought to enhance the safety of patients participating in the study," said Paul Foster, M.D., senior vice president and chief medical officer at Xencor.

About XmAb14045

XmAb14045 is a tumor-targeted antibody that contains both a CD123 binding domain and a cytotoxic T-cell binding domain (CD3) in a Phase 1 clinical trial for the treatment of acute myeloid leukemia (AML) and other CD123-expressing hematologic malignancies. An XmAb Bispecific Fc domain serves as the scaffold for these two antigen binding domains and confers long circulating half-life, stability and ease of manufacture on XmAb14045. CD123 is highly expressed on AML cells and leukemic stem cells, and it is associated with poorer prognosis in AML patients. Engagement of CD3 by XmAb14045 activates T cells for highly potent and targeted killing of CD123-expressing tumor cells.

On April 30, 2019 Ultragenyx Pharmaceutical Inc. (NASDAQ: RARE), a biopharmaceutical company focused on the development of novel products for serious rare and ultra-rare genetic diseases, reported that it will host a conference call on Monday, May 6, 2019 at 5pm ET to discuss first quarter 2019 financial results and provide a corporate update (Press release, Ultragenyx Pharmaceutical, APR 30, 2019, http://ir.ultragenyx.com/news-releases/news-release-details/ultragenyx-host-conference-call-first-quarter-2019-financial [SID1234535641]).

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The live and replayed webcast of the call will be available through the company’s website at View Source To participate in the live call by phone, dial (855) 797-6910 (USA) or (262) 912-6260 (International) and enter the passcode 3666589. The replay of the call will be available for one year.

On April 29, 2019 Sesen Bio (Nasdaq:SESN), a late-stage clinical company developing targeted fusion protein therapeutics for the treatment of patients with cancer, reported that Company management will host a conference call and webcast on Monday, May 13, 2019 at 8:00 a.m. EDT to review operating results for the first quarter ended March 31, 2019 and updated, preliminary primary and new secondary endpoint data from the Phase 3 VISTA trial of Vicinium for patients with high-risk non-muscle invasive bladder cancer who have been previously treated with bacillus Calmette-Guérin (Press release, Sesen Bio, APR 29, 2019, http://ir.sesenbio.com/news-releases/news-release-details/sesen-bio-host-conference-call-review-first-quarter-2019 [SID1234535438]).

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To participate in the conference call, please dial (844) 831-3025 (domestic) or (315) 625-6887 (international) and refer to conference ID 7176228. The webcast can be accessed in the Investor Relations section of the Company’s website at www.sesenbio.com. The replay of the webcast will be available in the investor section of the Company’s website at www.sesenbio.com for 60 days following the call.