On November 15, 2019 Bruker Corporation (Nasdaq: BRKR) reported it will present at the following conferences (Press release, Bruker, NOV 15, 2019, View Source [SID1234551386]):

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Stifel 2019 Healthcare Conference, New York, NY
Tuesday, November 19, 2019, at 1:15 p.m. Eastern Time
Gerald Herman, Chief Financial Officer

Jefferies 2019 London Healthcare Conference, London, UK
Thursday, November 21, 2019, at 8:00 a.m. GMT
Gerald Herman, Chief Financial Officer

A live audio webcast of the Stifel 2019 Healthcare Conference presentation will be available in the Investor Relations section of the Company’s website at View Source A replay will be posted on the Bruker Investor Relations website after the event and will be available for 30 days following the presentation.

On November 15, 2019 Applied DNA Sciences, Inc. (NASDAQ: APDN) ("Applied DNA" or the "Company") a leader in Polymerase Chain Reaction (PCR)-based DNA manufacturing for product authenticity, traceability solutions and nucleic acid-based biotherapeutic research, reported the closing of its previously reported underwritten public offering of 2,285,000 shares of common stock and warrants to purchase up to an aggregate of 2,285,000 shares of common stock (Press release, Applied DNA Sciences, NOV 15, 2019, View Source [SID1234551371]). Each share of common stock was sold together with one warrant to purchase one share of common stock at a combined effective price to the public of $5.25 per share and accompanying warrant. Gross proceeds, before underwriting discounts and commissions and estimated offering expenses, were approximately $12.0 million, not including any amounts received upon exercise of the warrants.

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The warrants are immediately exercisable at a price of $5.25 per share of common stock and will expire five years from the date of issuance. The shares of common stock and the accompanying warrants were sold together in the offering, but were issued separately.

Maxim Group LLC acted as the book-running manager and Joseph Gunnar & Co. LLC acted as a co-manager in connection with the offering.

Applied DNA has granted the underwriters a 45-day option to purchase up to an additional 342,750 shares of common stock and/or warrants to purchase up to 342,750 shares of common stock, at the public offering price less discounts and commissions.

The offering was conducted pursuant to the Company’s registration statement on Form S-1 (File No. 333-233830), as amended, previously filed with and subsequently declared effective by the Securities and Exchange Commission ("SEC") on November 13, 2019 as well as the Company’s subsequent registration statement on Form S-1 (File No. 333-234664), which became effective on November 13, 2019. A final prospectus relating to the offering has been filed with the SEC and is available on the SEC’s website at View Source Electronic copies of the final prospectus relating to this offering may be obtained from Maxim Group LLC, 405 Lexington Avenue, 2nd Floor, New York, NY 10174, at (212) 895-3745.

This press release shall not constitute an offer to sell, or the solicitation of an offer to buy, nor may there be any sale of these securities in any state or jurisdiction in which such an offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On November 15, 2019 Centene Corporation (NYSE: CNC) ("Centene" or the "Company") reported that it has commenced an offering to sell $7,000,000,000 of senior notes. The $7,000,000,000 of senior notes will include an add-on to its 5.375% senior notes due 2026 (the "2026 Notes"), new senior notes due 2027 (the "2027 Notes") and new senior notes due 2029 (together with the 2027 Notes, the "New Notes" and, together with the 2026 Notes, the "Notes"), subject to market and other conditions (Press release, Centene , NOV 15, 2019, View Source [SID1234551387]). The 2026 Notes will constitute a further issuance of the $1,800,000,000 aggregate principal amount of 5.375% senior notes due 2026 that were issued on May 23, 2018 and will have the same terms as such notes, other than the issue date, the issue price and the first interest payment date.

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Centene intends to use the net proceeds of the New Notes to finance the cash consideration payable in connection with Centene’s previously announced acquisition of WellCare Health Plans, Inc. ("WellCare") and to pay related fees and expenses. Centene expects to use the net proceeds of the 2026 Notes for general corporate purposes, including the repayment of revolver borrowings. Centene currently expects the acquisition to be completed by the first half of 2020. The acquisition is, however, subject to customary closing conditions, and Centene cannot guarantee that the acquisition will be completed at or about such time, or at all. The closing of this offering is not conditioned on the closing of the acquisition. If the acquisition is not consummated, the Company will be required to redeem the New Notes at a redemption price equal to 100% of the principal amount of the New Notes, plus accrued and unpaid interest, if any, to but excluding the redemption date. The 2026 Notes will not be subject to a special mandatory redemption.

The Notes will be offered to persons reasonably believed to be qualified institutional buyers pursuant to Rule 144A under the Securities Act of 1933, as amended (the "Securities Act"), and to non-United States persons outside the United States in compliance with Regulation S under the Securities Act. The Notes have not been registered under the Securities Act and may not be offered or sold in the United States without registration or an applicable exemption from the registration requirements.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of the securities in any jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration, qualification or exemption under the securities laws of any such jurisdiction.

On November 15, 2019 Skyhawk reported its fifth deal of the year, the company is moving into a new therapeutic area and adding $80 million to its cash reserve (Press release, Skyhawk Therapeutics, NOV 15, 2019, View Source [SID1234626570]). Skyhawk partnered with Celgene to discover and develop small molecules for autoimmune disease and cancer against hard-to-drug targets that have been clinically validated, or genetically associated with a disease.

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Skyhawk Therapeutics Inc. uses its SkySTAR platform to discover and develop small molecules capable of modulating RNA splicing within the spliceosome, dictating which exons are included in the final mRNA transcript and offering drug developers a mechanism to control protein expression at the level of mRNA. The therapeutic approach can be applied broadly to indications where attempts at drugging a target at the protein level have been unsuccessful (see "Splice Time")

On November 15, 2019 Bio-Path Holdings, Inc., (NASDAQ:BPTH), a biotechnology company leveraging its proprietary DNAbilize antisense RNAi nanoparticle technology to develop a portfolio of targeted nucleic acid cancer drugs, reported its financial results for the third quarter ended September 30, 2019 and provided an update on recent corporate developments (Press release, Bio-Path Holdings, NOV 15, 2019, View Source [SID1234551372]).

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"Throughout the third quarter we continued to make progress across all of our innovative RNAi nanoparticle therapeutic programs. Importantly, we continued treating patients and are nearing completion of the safety portion of the Phase 2 clinical study of prexigebersen in combination with decitabine in untreated AML and high risk MDS patients and refractory/relapsed AML and high risk MDS patients. Upon completion of this key milestone, we expect to begin the study of prexigebersen with decitabine plus venetoclax," said Peter Nielsen, President and Chief Executive Officer of Bio-Path Holdings. "Additionally, we filed an Investigational New Drug (IND) application for our second pipeline candidate, BP1002, and further strengthened and expanded our patent portfolio with the addition of a key new patent that protects our DNAbilize platform and underscores its novelty. In addition, an IND for prexigebersen in the treatment of solid tumors starting with ovarian and endometrial cancer is being finalized for filing. Patients diagnosed with recurrent ovarian or endometrial cancer often have poor outcomes and it is our hope that prexigebersen may provide clinical benefit for such patients."

"We are working toward completing IND enabling studies of BP1003, a novel liposome-incorporated STAT3 oligodeoxynucleotide inhibitor for the treatment of solid tumors, and expect to file an IND application for a Phase 1 study of BP1003 for the treatment of solid tumors, including pancreatic cancer in 2020. Pancreatic cancer patients have extremely limited treatment options, consequently, we are dedicated to moving this therapy forward as quickly as possible," added Mr. Nielsen.

Recent Corporate Highlights

·Appointed Martina Molsbergen to the Board of Directors. In October 2019, Bio-Path announced the appointment of Martina Molsbergen, Chief Executive Officer of C14 Consulting, to its Board of Directors. Her considerable experience in business development will be invaluable as Bio-Path seeks a variety of partnerships and collaborations in order to advance the Company’s DNAbilize platform technology.

·Updated Intellectual Property Portfolio with Addition of Recently Issued Second Platform Technology Patent. In September 2019, Bio-Path announced that the United States Patent and Trademark Office issued a patent with claims related to the Company’s proprietary liposomal delivery and antisense technology, DNAbilize, including its use in the treatment of cancers, autoimmune diseases and infectious diseases. This is the second U.S. patent issued for the Company’s platform technology.

·Dosed Patient in Amended Phase 2 Prexigebersen Trial in Acute Myeloid Leukemia. In August 2019, Bio-Path announced patient dosing in the amended Phase 2 trial of prexigebersen for the treatment of acute myeloid leukemia (AML), which was updated to include patients with high risk myelodysplastic syndrome (MDS) and refractory/relapsed AML patients. Bio-Path continues treating patients and is nearing completion of the safety portion of the amended Phase 2 study, which is evaluating prexigebersen in combination with decitabine. Upon successful completion of this safety assessment, the Company plans to add venetoclax to the prexigebersen/decitabine combination treatment.

Financial Results for the Third Quarter Ended September 30, 2019

·The Company reported a net loss of $2.2 million, or $0.78 per share, for the three months ended September 30, 2019, compared to a net loss of $3.1 million, or $5.38 per share, for the three months ended September 30, 2018.

·Research and development expenses for the three months ended September 30, 2019 decreased to $1.4 million, compared to $2.3 million for the three months ended September 30, 2018 primarily due to lower expenses in 2019 related to drug material releases for the Company’s Phase 2 clinical trials for prexigebersen in AML and CML.

·General and administrative expenses for the three months ended September 30, 2019 increased to $0.9 million, compared to $0.7 million for the three months ended September 30, 2018 primarily due to increased legal fees and insurance costs.

·As of September 30, 2019, the Company had cash of $15.4 million, compared to $1.0 million at December 31, 2018. Net cash used in operating activities for the nine months ended September 30, 2019 was $6.1 million compared to $4.8 million for the comparable period in 2018. Net cash provided by financing activities for the nine months ended September 30, 2019 was $20.5 million.

Conference Call and Webcast Information

Bio-Path Holdings will host a conference call and webcast today at 8:30 a.m. ET to review these third quarter 2019 financial results and to provide a general update on the Company. To access the conference call, please call (844) 815-4963 (domestic) or (210) 229-8838 (international) and refer to conference ID 2095674. A live audio webcast of the call and the archived webcast will be available on the Company’s website at www.biopathholdings.com.